Carcinogenic potential of duodenal reflux juice from patients with long-standing postgastrectomy

Abstract

AIM To determine whether study on the carcinogenic potential of reflux juice from patients with remote gastrectomy could clarify the inherent relationship between duodenal reflux and gastric stump cancer. METHODS A total of 37 reflux juice samples (13 BillrothI, 24 BillrothII) were employed in the present study. A two-stage transformation assay using BALB/c 3T3 cells was carried out to test the initiating or promoting activity of these samples. RESULTS Two of 18 (11.1%) reflux samples exerted initiating activities, whereas 9/19 (47. 4%) samples enhanced the MNNG-initiating cell transformation, suggesting the duodenal reflux juice might more frequently possess the tumorpromoter activity (P = 0.029). In addition, there was no difference in initiating activities of the samples irrespective of surgical procedures (P = 0.488), while Billroth II samples exhibited stronger tumor-promoter activity than Billroth I samples (P = 0.027). Furthermore, the promoter activities were well correlated with the histological changes of the stomas (r s = 0.625, P = 0.004), but neither their cytotoxicities nor initiating activities had this correlation (Probabilities were 0.523 and 0.085, respectively

Dietary supplementation with carbonate increases expression of ornithine decarboxylase and proliferation in gastric mucosa in a rat model of gastric cancer

“…Despite the fact that very little interest has been focused on a possible role of dietary carbonate in the development of gastric cancer, it is well recognised that this ion is a major constituent of the pancreaticoduodenal juice 39, 40. More importantly, this type of succus has been implicated as a mediator of reflux‐induced gastric cancer 35, 37, 41, 42, 43. In a recent study,11 we hypothesised that an elevated expression of ODC could be the molecular mechanism whereby carbonate increases the proliferation of gastric cells and the incidence of gastric cancer 11.…”

Screening of Helicobacter pylori Infection After Gastrectomy for Cancer or Peptic Ulcer

“…There is a chance that some of the morphological changes of the residual mucosa were already present at surgery in relation to the causative disease and that, in the postoperative period, these lesions persisted, pro-gressed, and/or even regressed in relation to HP status [39][40][41][42][43] and undefined other multiple factors. 44 However, it was impossible for us to retrospectively ascertain the status of the gastric mucosa at the time of surgery. We observed that the prevalence of mucosal lesions in both groups was irregularly related to the time.…”

Evaluation of estrogen receptor expression and its relationship with clinicopathologic findings in gastric cancer

“…[ 2 ] Chemotherapy and radiotherapy are used as adjuvant treatments for patients with T2, 3N in advanced or inoperable GC. [ 3 4 5 6 7 8 ]…”