Carcinogenic nitrogen compounds. Part LVII. Hexacyclic acridines derived from phenanthrene and fluorene

Abstract

The use of 9-and 2-aminophenanthrene for the preparation of tribenzo-and benzonaphtho-acridines and related heterocycles has been investigated : with 2-aminophenanthrene, the site of the acridine cyclisations is shown to be position 1. Benzoindenoacridines isosteric with benzonaphthoacridines were prepared from 4-aminofluorene.

An efficient ultrasound promoted catalyst-free protocol for the synthesis of chromeno[4,3-b]quinolin-6-ones

“…Chromeno [4,3-b]quinolin-6-one derivatives (3a-n) are important class of chromeno-quinolines and the most conventional approach for their synthesis involves the reaction of 4-hydroxycoumarins with anilines and paraformaldehyde at 220-240 • C under vacuum. 19 Tabakovic et al have reported their synthesis starting from 4-hydroxycoumarin under Vilsmeier-Haack conditions. 20 Asherson et al have reported their synthesis from 3-((dimethylamino)methyl)-4-hydroxy-2Hchromen-2-one and anilines but with lower yields.…”

Preparation, proteolysis and reversible oxidation of highly purified Azotobacter vinelandii polynucleotide phosphorylase

“…[32P]P1 with the terminal phosphate of ADP (Grunberg-Manago et al 1956;Thang, 1967). The reaction mixture (0.lml) contained: tris-HCI buffer, pH8.0, lOu.tmol;…”

“…The discovery afforded a probable explanation for the lack of reproducibility (Ochoa, & Mii, 1961;Ochoa, Krakow & Basilio, 1963) and low yield (Thang, 1967) of the published purification procedures and made possible the development of an effective method for the isolation in good yield of highly purified A. vinelandii polynucleotide phosphorylase in its reduced form.…”