Carcinogenic effect of gibberellin A₃in Swiss Albino Mice

Abstract

Gibberellin A3 is a plant growth regulator used in many countries, including Egypt, to increase the growth of fruits and vegetables. The carcinogenic effect of gibberellin A3 was investigated in this study with Swiss albino mice. Administration of gibberellin A3 by gavage for 22 months induced a significant increase in their body weights. Tumors were induced in 18% of the males and 36% of the females and were located in the skin of the axillary region (sebaceous adenomas), breast (adenocarcinomas), and lung (adenocarcinomas and secondary metastatic deposits from breast tumors). Bronchocentric granulomas were induced in animals exposed to gibberellin A3 for 14 months. These results indicate that gibberellin A3 was carcinogenic in mice.

Synthesis and effect of a new Terbium gibberellic complex on the histopathological alteration induced by Gibberellic acid on liver and kidney of mice Mus musculus

“…[10] The alarming toxicity and hazardous effects of Gibberellic acid on the health of human and animals were pronounced through exposure to residues of Gibberellic acid in diet derived from consumption of different kinds of fruits and vegetables that exposed to Gibberellic acid. [14,15] In the same scenario, Hepatocellular carcinoma was induced after exposure of Bufo regularis to Gibberellic acid. [12,13] Carcinogenic effect and tumor formation of Gibberellic acid have been documented after treatment of mice for a long time.…”

Plant Hormones, Gibberellins and Abscissins, and Their Potential Effects on Mammalian Species

“…A3 (GA3) was tested in Swiss albino mice by El-Mofty et al [8], who observed an increase in the incidence of mammary tumours in both males and females, above that in the controls, when the animals were given twice weekly by gavage 0.3 ml saline solutions containing 3 ppm of pure GA3 for 22 months. The incidence of tumours in the males is given as 18%, and in females as 36%; some of the mammary tumours metastasized into the lung [8].…”

“…The incidence of tumours in the males is given as 18%, and in females as 36%; some of the mammary tumours metastasized into the lung [8].…”

Structural Changes Induced By Gibberellic Acid in the Renal Cortex of Adult Male Albino Rats

“…However, several studies demonstrated that, the chronic consumption of gibberellic acid increased tumor formation and oxidative stress, hepatocellular carcinomas in 16% of the animals [7]. Also, it was shown that gibberellic acid induced breast and lung adenocarcinomas in mice [8]. Gibberellic acid was found to induce chromosomal aberrations in lymphocytes of humans [9] and mice [10].…”