Carcinogenic and co-carcinogenic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a host-mediated in vivo/in vitro assay

Massa, Th.; Esmaelli, A.; Schlatterer, B; Hagenmaier, Hanspaul; Prakash, Chandra

doi:10.1016/0045-6535(91)90034-b

Cited by 2 publications

(4 citation statements)

References 18 publications

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“…Several older approaches have been mentioned for the screening of carcinogenicity (34-45), only our system covers the key problems related to carcinogenicity of chemicals (9,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

“…Table III summarizes the transforming potentials of different compounds using our system compared with genotoxicity as well as mutagenicity data of these compounds as derived from the Ames test, micronucleus test and COMET assay, reported in literature 20) is apparent in our system. Low doses of diphenylhydantoin, which exhibited no transforming potential when used alone in the in vivo/in vitro assay, gained a high oncogenic potential when simultaneously administered with low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (12,13).…”

Section: Host-mediated In Vivo/in Vitro Assay and Transforming Potentialmentioning

confidence: 99%

“…In our in vivo/in vitro assay, different immortalized peritoneal macrophage cell lines with tumorigenic characteristics were established: TBrDD cells [after administration of 2,3,7,8-tetrabromodibenzo-p-dioxin (12)], Aona cells [after administration of 10% of the median lethal dose 2-nitroanisole (20)] and EED cells [after administration of 17α-ethinylestradiol (21)]. All immortalized cell lines revealed similar characteristics: Cells were larger in size than normal macrophages.…”

Section: Immortalized Cell Linesmentioning

confidence: 99%

“…For this review, 11 articles on the host-mediated in vivo/in vitro assay system, published by our working group in the period between 1990 and 2006, were used (9,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21).…”

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confidence: 99%

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Applicability of a Host-mediatedIn Vivo/In VitroModel in Screening for the Carcinogenic Potential of Chemicals

et al. 2022

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Based on a publication of Tomasetti and Vogelstein in 2015, in which the risk of cancer development is postulated to be just one-third caused by genetic predisposition and environmental factors, it seemed worth focusing again on the value of test systems for screening chemicals for their carcinogenicity. This review aims to firstly summarize data on a host-mediated in vivo/in vitro assay developed by our working group to screen the tumorigenic potential of chemicals. Subsequently, in this article the importance and advantages of host-mediated in vivo/in vitro assays in general have been compared with in vivo and in vitro tests. The applicability of the host-mediated in vivo/in vitro assay system within broad screening strategies is discussed. The main intention of this review is to stimulate developments of newer approaches in the field of carcinogenic testing.

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Section: Discussionmentioning

confidence: 99%

Section: Host-mediated In Vivo/in Vitro Assay and Transforming Potentialmentioning

confidence: 99%

Section: Immortalized Cell Linesmentioning

confidence: 99%

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confidence: 99%

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Applicability of a Host-mediatedIn Vivo/In VitroModel in Screening for the Carcinogenic Potential of Chemicals

et al. 2022

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Low molecular weight proteins secreted by peritoneal macrophages obtained from 2,3,7,8‐tetrabromodibenzo‐p‐dioxin‐treated NMRI mice

et al. 1997

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The protein secretion patterns in a macrophage-like cell line (CBrD), established from the peritoneal cells of NMRI mice treated with the dioxin analog 2,3,7,8-tetrabromodibenzo-p-dioxin (TBrDD), were analyzed by high resolution two-dimensional gel electrophoresis (2-D PAGE), and compared to the pattern of proteins secreted by control macrophages which were intraperitoneally activated by bacterial lipopolysaccharide. The most striking alterations were observed in the low molecular range. The transformed cells encode a number of low molecular mass proteins (10-20 kDa) which were not detected in control cells under identical experimental conditions. The protein pattern with respect to isoelectric point, molecular weight, optical density (OD) and area of the spot (in mm2) has been depicted by computer analysis in relation to a standardized spot outline and the spot's background (in OD). It is concluded that the transformation of murine peritoneal macrophages by TBrDD leads to an upregulation of proteins, in particular of low-molecular-weight proteins.

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Carcinogenic and co-carcinogenic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a host-mediated in vivo/in vitro assay

Cited by 2 publications

References 18 publications

Applicability of a Host-mediatedIn Vivo/In VitroModel in Screening for the Carcinogenic Potential of Chemicals

Applicability of a Host-mediatedIn Vivo/In VitroModel in Screening for the Carcinogenic Potential of Chemicals

Low molecular weight proteins secreted by peritoneal macrophages obtained from 2,3,7,8‐tetrabromodibenzo‐p‐dioxin‐treated NMRI mice

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