Carcinogenic action of 5-nitroacenaphthene

Takemura, Nobuyuki; Hashida, Chise; Terasawa, Michio

doi:10.1038/bjc.1974.225

Cited by 32 publications

(7 citation statements)

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“…Fifteen out of the 19 nitroarenes were mutagenic to Salmonella typhimurium TAI 00 and/or TA98. 5-Nitroacenaphthene [33], 2-nitrofluorene [34], 1 -nitropyrene [35,36], and 2,7-dinitrofluorene [37] are carcinogenic to experimental animals. 6-Nitrochrysene has tumor initiating activity on mouse skin [38].…”

Section: Nitroarene Analysis In Airborne Particulatesmentioning

confidence: 99%

Application of capillary gas chromatography to environmental analysis

Matsushita¹,

Iida²

1986

J. High Resol. Chromatogr.

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Section: Nitroarene Analysis In Airborne Particulatesmentioning

confidence: 99%

Application of capillary gas chromatography to environmental analysis

Matsushita¹,

Iida²

1986

J. High Resol. Chromatogr.

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“…(68) Several NO,-polycyclic organic compounds have been reported to induce malignant tumors in rodent species. (69)(70)(71)(72) Table VII compares four diesel engmes (Nissan, Volkswagen Rabbit, Oldsmobile, and Caterpillar) and one gasoline engine (Mustang 11) for relative potencies normalized to the Nissan sample as measured by skin tumor initiation and in vitro tests: mouse lymphoma, SCE, and Ames. Results from the Ames, mouse lymphoma, and SCE bioassays are in excellent agreement with those from the mouse skin tumor initiation bioassay except for the SCE bioassay ( -MA) with the Oldsmobile sample.…”

Section: Methy1-9h-pyrid0[23-b]indole)(~~)mentioning

confidence: 99%

Comparative Potency Method for Cancer Risk Assessment: Application to Diesel Particulate Emissions¹

et al. 1983

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An estimation of the human lung cancer “unit risk” from diesel engine particulate emissions has been made using a comparative potency approach. This approach involves evaluating the tumorigenic and mutagenic potencies of the particulates from four diesel and one gasoline engine in relation to other combustion and pyrolysis products (coke oven, roofing tar, and cigarette smoke) that cause lung cancer in humans. The unit cancer risk is predicated on the linear nonthreshold extrapolation model and is the individual lifetime excess lung cancer risk from continuous exposure to 1 μg carcinogen per m3 inhaled air. The human lung cancer unit risks obtained from the epidemiologic data for coke oven workers, roofing tar applicators, and cigarette smokers were, respectively, 9.3 × 10−4, 3.6 × 10−4, and 2.2 × 10−6 per μg particulate organics per m3 air. The comparative potencies of these three materials and the diesel and gasoline engine exhaust particulates (as organic extracts) were evaluated by in vivo tumorigenicity bioassays involving skin initiation and skin carcinogenicity in SENCAR mice and by the in vitro bioassays that proved suitable for this analysis: Ames Salmonella microsome bioassay, L5178Y mouse lymphoma cell mutagenesis bioassay, and sister chromatid exchange bioassay in Chinese hamster ovary cells. The relative potencies of the coke oven, roofing tar, and cigarette smoke emissions, as determined by the mouse skin initiation assay, were within a factor of 2 of those determined using the epidemiologic data. The relative potencies, from the in vitro bioassays as compared to the human data, were similar for coke oven and roofing tar, but for the cigarette smoke condensate the in vitro tests predicted a higher relative potency. The mouse skin initiation bioassay was used to determine the unit lung cancer risk for the most potent of the diesel emissions. Based on comparisons with coke oven, roofing tar, and cigarette smoke, the unit cancer risk averaged 4.4 × 10−4. The unit lung cancer risks for the other, less potent motor‐vehicle emissions were determined from their comparative potencies relative to the most potent diesel using three in vitro bioassays. There was a high correlation between the in vitro and in vivo bioassays in their responses to the engine exhaust particulate extracts. The unit lung cancer risk per μg particulates per m3 for the automotive diesel and gasoline exhaust particulates ranged from 0.20 × 10−4 to 0.60 × 10−4; that for the heavy‐duty diesel engine was 0.02 × 10−4. These unit risks provide the basis for a future assessment of human lung cancer risks when combined with human population exposure to automotive emissions.

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“…Conference on "Nursing Science: Today and Beyond" A research conference, entitled "Nursing Science: Today and Beyond," will be held September [22][23][24] 1983 at the Sheraton Park Place Hotel in Minneapolis, Minnesota. Sponsored by the American Nurses' Association Council of Nurse Researchers, the conference will explore current and future directions for nursing research.…”

Section: Acknowledgmentsmentioning

confidence: 99%