Carcinogenetic impact of alcohol intake on squamous cell carcinoma risk of the oesophagus in relation to tobacco smoking

Lee, Chien-Hung; Wu, Deng‐Chyang; Lee, Jang-Ming; Wu, I-Chen; Goan, Yih‐Gang; Kao, Eing-Long; Huang, Hsiao‐Ling; Chan, Te-Fu; Chou, Shah‐Hwa; Chou, Yi-Pin; Chen, Pei–Shih; Ho, Chi-Kung; He, Jiang; Wu, Ming-Tsang

doi:10.1016/j.ejca.2007.01.039

Cited by 85 publications

(70 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Data on the types of alcoholic beverage ingested, the amount of ethanol in each type of beverage, the average frequency of intake per week and the number of drinks per day, were obtained and converted to the total consumption of alcohol in grams per day, as previously described. 7 …”

Section: Data Collectionmentioning

confidence: 99%

“…6,7 Although the biological mechanisms underlying alcoholinduced carcinogenesis have not been defined fully, DNA damage by carcinogenic acetaldehyde (the pivotal metabolite of ethanol) is one of the powerful events for the development of upper aerodigestive tract (UADT) neoplasms. 8,9 In an experimental study, a 7-folds higher level of acetaldehyde-DNA adduct has been detected in heavy alcohol drinkers than in controls.…”

Section: Uiccmentioning

confidence: 99%

See 1 more Smart Citation

Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis

Lee¹,

Wu²,

Wu³

et al. 2009

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

Genetic variants in alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) genes modulate acetaldehyde removal upon alcohol ingestion. Although these genetic vulnerabilities have been linked to higher esophageal squamous cell carcinoma (ESCC) risks, it is unclear whether they also determine the time of malignancy presentation. The purpose of this investigation was to unravel genotoxic effects of the two alcohol-metabolizing genes with regard to alcohol and tobacco consumption on the age at ESCC diagnosis and tumor dissemination. ADH1B/ALDH2 genotyping was performed on lymphocyte DNA specimens taken from 406 consecutively registered incident patients with pathology-proven ESCC. To fully utilize individual genetic and survival information, survival analyses and gene-longevity applied approaches were introduced. Among heavy drinkers, the ADH1B Arg/Arg (55 years) and ALDH2 Glu/Lys genotypes (54 years) were found to confer a 15 and 16 years earlier carcinoma diagnosed age than His/His and Glu/Glu nondrinkers (both 70 years), respectively. For drinkers, 1-year age advancement was, separately, associated with a 0.977 and 0.953-fold stepwise reduced likelihood of being ADH1B Arg homozygote and ALDH2 Lys variant. Noticeably elevated hazard-ratio (HR) for drinkers of ADH1B slow-form genotype and ALDH2 inactive-form allele were identified in smokers (HR 5 2.3-2.6), but no in nonsmokers. In smokers, appreciably higher cumulative cancer onset risks were correspondingly recognized from the age of 45 and 49 upward among any 1 Lys allele and Arg/Arg 1 Glu/Glu combined-ADH1B/ALDH2-genotype drinkers than nondrinkers. In conclusion, consumption of tobacco and alcohol, coupled with genetic susceptibilities associated with acetaldehyde elimination, as modulated by ADH1B and ALDH2 genotypes, determines a substantial magnitude of tumorigenetic effect on earlier age ESCC diagnosis. ' 2009 UICC Key words: age factor; alcohol drinking; alcohol dehydrogenase; aldehyde dehydrogenase; areca; esophageal neoplasms; smoking Carcinoma stemming from the esophagus ranks as the eighth most common cancer in the world and is one of the deadliest and, yet, most neglected forms of cancer.1 Given the insidious nature of this neoplasm, it has been found that more than 50% of the eventual patients already have unresectable and/or metastatic conditions at the time of tumor presentation.2 Although recent advances in the diagnosis, staging and treatment of esophageal cancer have brought about noteworthy improvement toward some manner of survival, 75% of the patients still die within 1 year of diagnosis, and currently just 5-14% of such patients survive at least 5 years.2,3 Due, in part, to the high case fatality rate, younger esophageal carcinoma onset has been linked to a shorter life expectancy. This leads to a number of challenging health-related issues for the respective family, as well as to substantial work productivity losses for the country.Alcohol intake is a well-recognized determinant for squamous cell carcinoma (SCC) of the esopha...

show abstract

Section: Data Collectionmentioning

confidence: 99%

Section: Uiccmentioning

confidence: 99%

Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis

Lee¹,

Wu²,

Wu³

et al. 2009

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…The interaction between tobacco smoking and alcohol drinking has been extensively studied, and it has been suggested that they interact in a multiplicative manner with respect to the risk of esophageal cancer (De Stefani et al 1990;Lee et al 2007;Brown et al 2008). However, Steevens et al (2010) found no interaction effect in their prospective study of the risk of adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Alcohol Consumption as a Risk Factor for Esophageal Adenocarcinoma in North China

Zhang

Ling

Wakai

et al. 2011

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

The incidence of esophageal adenocarcinoma has been rising in many countries, while esophageal squamous cell carcinoma has remained stable or even declined in the same populations over the identical periods. These differences in trends indicate that these cancer subtypes may have a different etiology, which may be caused by lifestyle factors such as alcohol consumption and cigarette smoking. Therefore, a matched case-control study to clarify the risk factors of alcohol and tobacco intake on the development of esophageal adenocarcinoma was collected in Hebei Province of China. The life expectancy of the study area was around 70 years old. In the present study, 98 patients younger than 65 years who were diagnosed with esophageal adenocarcinoma and had initial surgeries (cases) were matched with 294 healthy adults (controls) at a ratio of 1:3 according to sex and age. We found the proportions of drinkers and smokers among cases were 48.0% and 60.2%, respectively, versus 21.2% and 43.5% among controls. Univariate conditional logistic regression analyses revealed that the odds ratios (ORs) showed a nearly monotonic increase for the duration of alcohol consumption and duration of tobacco smoking. Multivariate conditional logistic regression analysis indicated that only alcohol consumption was a significant risk factor for esophageal adenocarcinoma. Additional analysis of the combination of amount and duration of alcohol consumption indicated that heavy drinkers (> 30 ml/day) had significantly higher ORs, irrespective of the duration of alcohol consumption. In conclusion, heavy alcohol consumption increases the risk for esophageal adenocarcinoma independent of the duration of such consumption.

show abstract

“…Three hundred and seventeen newly pathologically proven ESCC patients (301 males and 16 females) were recruited from two medical centers in the Kaohsiung metropolitan area in southern Taiwan, including the Kaohsiung Medical University Hospital (KMUH) and the Kaohsiung Veterans General Hospital (KVGH) between 2000 and 2007. The detailed information was described elsewhere [18] . Patients with newly pathologically proven oral SCC (n = 199), gastric (n = 196) and colon adenocarcinoma (n = 240) were recruited from the KMUH in the same period.…”

Section: Selection Of Cases and Controlsmentioning

confidence: 99%

Association between Helicobacter pylori seropositivity anddigestive tract cancers

Wu²,

Yu³

et al. 2009

WJG

Self Cite

View full text Add to dashboard Cite

AIM:To explore the role of Helicobacter pylori (H pylori ) infection on the risk of digestive tract cancers. METHODS:In total, 199 oral squamous-cell carcinoma (SCC), 317 esophageal SCC, 196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori infection. Two hospital-and one community-based control groups were used for the comparisons. H pylori seropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG. RESULTS: Presence of H pylori infection was signifi-cantly inversely associated with esophageal SCC [adjusted odds ratio (AOR): 0.315-0.472, all P -value < 0.05] but positively associated with gastric adenocarcinoma (both cardia and non-cardia) (AOR: 1.636-3.060, all P -value < 0.05) in comparison to the three control groups. Similar results were not found in cancers of the oral cavity and colon. CONCLUSION: Our findings support the finding thatH pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.

show abstract

Carcinogenetic impact of alcohol intake on squamous cell carcinoma risk of the oesophagus in relation to tobacco smoking

Cited by 85 publications

References 28 publications

Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis

Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis

Alcohol Consumption as a Risk Factor for Esophageal Adenocarcinoma in North China

Association between Helicobacter pylori seropositivity anddigestive tract cancers

Contact Info

Product

Resources

About