Carcinoembryonic antigen, neuron‐specific enolase and cytokeratin fragment 19 (CYFRA 21‐1) levels in induced sputum of lung cancer patients

Hillas, Georgios; Moschos, Charalampos; Dimakou, Katerina; Vlastos, Fotis; Avgeropoulou, Stavrina; Christakopoulou, Ioulia; Rasidakis, A; Bakakos, Petros

doi:10.1080/00365510701883172

Cited by 9 publications

(4 citation statements)

References 23 publications

(27 reference statements)

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“…Serum CYFRA 21-1 level was not influenced by sex and smoking habits [38, 39], which was found to be an independent prognostic factor of survival and tumour relapse [40]. The meta-analysis about prognostic significance of CYFRA 21-1 has been studied in several articles, which have indicated that high level expression of CYFRA 21-1 implies a poor prognosis [32, 34, 41–48]. In this study, we found that the 2-year overall survival in the high level group was significantly lower than that in the low level group group, which is consistant with studies previous.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of CYFRA 21-1 as a prognostic indicator and its predictive correlation with clinicopathological features in Non-small Cell Lung Cancer: A meta-analysis

Zhang

Yang

et al. 2016

Oncotarget

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AIMTo evaluate the value of Cytokeratin 19 fragment for its survival prognostic indicator and predictive correlation with clinicopathological features in Non-small Cell Lung Cancer.METHODSEligible studies or databases for articles were retrieved via search systematically. Pooled effect was calculated to evaluate the association between Cytokeratin 19 fragment level and long-term overall survival, as well as the tumor clinicopathological features in Non-small Cell Lung Cancer patients. A fixed-effects or random-effects model was used to calculate the Pooled risk ratios (RRs) and corresponding 95 % confidence intervals (CIs).RESULTSSix studies were up to the selection criteria. This meta-analysis indicated that Cytokeratin 19 fragment high level expression correlated with lower 2-year overall survival (RR =0.47; 95%CI: 0.28-0.79), higher Tumor Node Metastasis stage (II+III+IV) (RR =1.43; 95%CI: 1.15-1.76) in Non-small Cell Lung Cancer. The pooled RR estimates indicated that there is no statistical significance of Cytokeratin 19 fragment level expression in the advanced Non-small Cell Lung Cancer (IIIB+IV) (RR =1.43, 95% CI: 0.85-2.43).CONCLUSIONCytokeratin 19 fragment is a negative prognosis indicator and its high level expression indicates higher Tumor Node Metastasis pathological stage (II+III+IV) in Non-small Cell Lung Cancer. In advanced Non-small Cell Lung Cancer, the level of serum Cytokeratin 19 fragment appears to provide more prognostic information than it does for clinical Tumor Node Metastasis stage information. Further studies are required to confirm our results.

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Section: Discussionmentioning

confidence: 99%

Systematic review of CYFRA 21-1 as a prognostic indicator and its predictive correlation with clinicopathological features in Non-small Cell Lung Cancer: A meta-analysis

Zhang

Yang

et al. 2016

Oncotarget

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“…27 Elevated CYFRA 21-1 levels have also been shown in induced sputum of lung cancer patients. 28 The current study of CYFRA 21-1 did not have controls of other malignancies.…”

Section: Introductionmentioning

confidence: 93%

The Value of Molecular Biomarkers in Biliary Tract Cancer in the Era of Targeted Therapy

Anand

Purl²,

Dhar

2011

Journal of Clinical and Experimental Hepatology

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“…In addition, serum tumour markers are not useful in lung cancer diagnosis (1). The diagnosis of lung cancer is based on the histological and cytological examination of material usually obtained by bronchoscopy (endobronchial biopsies, washings, and brushings) (19). However, despite the high sensitivity of this technique in detecting tumours, in some cases false negative results can be seen (20).…”

Section: Introductionmentioning

confidence: 99%

“…The source of bronchogenic carcinoma is the bronchial epithelium (19). In addition, ADA production by neoplastic cells is increased (4,7) and it could be assumed that respiratory secretions from lung cancer patients may contain high levels of ADA.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

Nikkhoo¹,

Sigari²,

Ghaderi³

et al. 2013

Journal of Medical Biochemistry

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SummaryBackground: This study aimed to determine adenosine deaminase (ADA) activity as a possible screening tool in lung cancer patients. Methods: Blood samples were collected from 30 subjects with positive pathological tests and 62 patients with negative pathological tests as a control group. The enzymatic activity of total ADA and its isoenzymes was determined. Results: tADA and ADA2 isoenzyme activity was significantly higher in cancerous patients compared to benign controls in serum and BAL fluid. Using a cut-off level of respectively 35.22 U/L and 31.80 U/L for BAL total ADA and ADA2, sensitivity and specificity were 100% and 81% for total ADA and 95% and 98% for ADA2. Conclusions: Adenosine deaminase may play important roles in the pathophysiology of lung cancer and because of its

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Carcinoembryonic antigen, neuron‐specific enolase and cytokeratin fragment 19 (CYFRA 21‐1) levels in induced sputum of lung cancer patients

Abstract: Of tumour markers in induced sputum, sputum CYFRA 21-1 offered the best predictive values, although not sufficiently satisfactory to suggest its routine use in lung cancer diagnosis.

Cited by 9 publications

References 23 publications

Systematic review of CYFRA 21-1 as a prognostic indicator and its predictive correlation with clinicopathological features in Non-small Cell Lung Cancer: A meta-analysis

Systematic review of CYFRA 21-1 as a prognostic indicator and its predictive correlation with clinicopathological features in Non-small Cell Lung Cancer: A meta-analysis

The Value of Molecular Biomarkers in Biliary Tract Cancer in the Era of Targeted Therapy

Diagnostic Utility of Adenosine Deaminase in Serum and Bronchoalveolar Lavage Fluid for Screening Lung Cancer in Western Iran

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