Carcinoembryonic antigen (CEA) and related antigens in blood cells and hematopoietic tissues

CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins

“…The interaction was not inhibited by addition of heparin, but was strongly inhibited by a mAb specific for CGM1. was found that antibodies to CEA also reacted with normal cells and identified a number of closely related, crossreacting antigens, initialy termed NCAs (35)(36)(37). The CEA gene, located in human chromosome 19 (38), is a member of a family of Ͼ17 expressible closely related genes (39) that belong to the Ig gene superfamily (40).…”

Mapping epitope characteristics on carcinoembryonic antigen

“…The cross-reactions noted with erythrocytes, however, were not due to the known blood group A or precursor H antigen specificities (Rogers, 1983), since all antibodies were subjected to an agglutination test to exclude such antibodies from this study. Reactivity with polymorphonuclear neutrophils, on the other hand, is likely to be due, in part, to normal cross-reacting antigen (NCA) (Bordes et al, 1975;Burtin & Fondaneche, 1979 the NCA reactivity could be reliably quantitated by radioimmunoassay. Using the latter technique MA/200 and IC12 gave 9 and 4% cross-reactivity respectively with purified NCA.…”

A monkey antigen crossreacting with carcinoembryonic antigen, CEA

“…CEA is associated with the membrane of cancerous cells of entodermal origin (Herberman et al, 1975), NCA with the membrane of certain normal leucocytes (Bordes, Knobel and Martin, 1975). The two antigens crossreact immunologically.…”