Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders

Moore, Terrence; Kupchik, Herbert Z.; Marcon, Nathalie; Zamcheck, Norman

doi:10.1007/bf02233781

Cited by 278 publications

(74 citation statements)

References 5 publications

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“…This may also explain the rises in plasma CEA which can occur with gastointestinal inflammatory conditions (Moore et al, 1971;Holyoke, Reynoso and Chu, 1972;Laurence etal., 1972;Reynoso etal., 1972). Were this true, a closer examination of the metabolic fate of CEA is warranted, together with the development of other diagnostic methods which employ, in conjunction with plasma, the other known "a"68 sources of CEA such as faeces and thoracic duct lymph.…”

Section: Organ Culturesmentioning

confidence: 96%

The monolayer and organ culture of human colorectal carcinomata and the associated "normal" colonic mucosa and their production of carcinoembryonic antigens

Bręborowicz¹,

Easty²,

Birbeck³

et al. 1975

Br J Cancer

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Summary.-The carcinoembryonic antigen (CEA) was produced and released by human colorectal carcinomata and also the normal attached mucosa when maintained in both monolayer and organ cultures Immunoperoxidase cytochemical methods were employed for the cellular localization of CEA which was demonstrable only on the neoplastic cells. Gel filtration and immunological methods confirmed that CEA, produced by normal and neoplastic cells, had properties similar to " authentic " CEA derived from metastatic colorectal carcinomata. In addition, two other CEA cross-reacting macromolecules, neither of which was CCEA-2, were produced by these tumours in culture.

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Section: Organ Culturesmentioning

confidence: 96%

The monolayer and organ culture of human colorectal carcinomata and the associated "normal" colonic mucosa and their production of carcinoembryonic antigens

Bręborowicz¹,

Easty²,

Birbeck³

et al. 1975

Br J Cancer

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“…Further studies have indicated that CEA or CEA-like materials may be detected in, in addition to tissues of entodermal origin, a large variety of normal and neoplastic tissues, such as lung, breast (Moore et al, 1971;Laurence et al, 1972) urogenital tract (Hall et al, 1972;Neville et al, 1973) and erythrocyte membranes (Nery, Bullman and Barsoum, 1973;Neville and Laurence, 1974).…”

mentioning

confidence: 99%

Detection of carcinoembryonic-like antigen on melanoma cells by leucocyte-dependent-antibody assays

Morgan¹,

McCarthy²,

Hersey³

1977

Br J Cancer

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CEA-like antigen has been detected on the surface of some melanoma cells using a rabbit antiserum raised against CEA antigen in 51Cr-release leucocyte-dependent cytotoxic-antibody (LDA) assays. The CEA antigen used for production of the antiserum was shown to be immunologically pure by immunoelectrophoresis procedures and reacted with a reference serum to CEA. The specificity of the CEA antiserum for CEA on the melanoma cells was further shown by removal of reactivity to melanoma cells after absorption on CEA affinity columns. LDA activity to CEA was also shown in a serum taken during pregnancy. No CEA LDA activity was found in several melanoma sera. These findings suggest that CEA may have biological significance in tumour rejection, and that CEA assays may be of value in monitoring disease activity in melanoma patients. Images Fig. 1

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“…Recently, Ablev (1968) and Gold and Freedman (1965) proposed the immunochemical diagnostic methods for cancer detection. However, it was clarified that both methods were not specific for cancerous patients by further studies (Moore et al 1971 …”

mentioning

confidence: 99%

The Lipid-Chemical Features of the Biopsied Human Liver Tissues of Patients with Malignant Neoplastic Diseases

Nakazawa

Yamagata

Miura

1976

Tohoku J. Exp. Med.

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Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders

Cited by 278 publications

References 5 publications

The monolayer and organ culture of human colorectal carcinomata and the associated "normal" colonic mucosa and their production of carcinoembryonic antigens

The monolayer and organ culture of human colorectal carcinomata and the associated "normal" colonic mucosa and their production of carcinoembryonic antigens

Detection of carcinoembryonic-like antigen on melanoma cells by leucocyte-dependent-antibody assays

The Lipid-Chemical Features of the Biopsied Human Liver Tissues of Patients with Malignant Neoplastic Diseases

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