Carcino‐sarcoma of the gall bladder

Surgical management of gallbladder sarcomatoid carcinoma

“…The most common histological type of gallbladder cancer is adenocarcinoma, and sarcomatoid carcinoma is extremely rare [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] . Chao et al [1] have reported the incidence of sarcomatoid carcinoma from gallbladder cancer as 4.1%.…”

“…Chao et al [1] have reported the incidence of sarcomatoid carcinoma from gallbladder cancer as 4.1%. It has been described that sarcomatoid carcinoma arises from totipotent stromal stem cells [8] and is composed of epithelial and mesenchymal components that contain undifferentiated spindle or stellate cells [3,4,6,8,9,11,[14][15][16][17][18] . The cancer was first reported by Landsteiner in 1907, and until now, only 44 cases have been reported in the English-language literature, with an age range of 45-91 years [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] .…”

“…Symptoms may persist from several days to years. Liver function tests are normal, except in patients with obstructive jaundice caused by tumor invasion of the biliar y tract [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] . Most cases have been reported to have normal CEA and CA19-9 levels, and in our series, the CEA level was elevated in one case and CA19-9 level was elevated in two cases.…”

“…Tumors that possess epithelial and mesenchymal components are so-called sarcomatoid carcinomas. Gallbladder sarcomatoid carcinoma is a rare and atypical subset of gallbladder carcinoma, and only 44 cases have been described in the English-language literature worldwide [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] . All of these have been case reports and have little information about the clinical behavior and optimal treatment of these tumors.…”

A So-Called Carcinosarcoma of the Gallbladder in a Patient with Multiple Anomalies. A Case Report.

“…About 50 cases of these tumors were found on record in the Japanese literature [3]. Mehrotra et al [4] have reported that the diagnosis of "true" carcinosarcoma is based on the differentiation of the mesenchymal element into neoplastic bone and osteoid. Albores-Saavedra and Henson [5] also have stressed the importance of the presence of malignant cartilage and bone as the basis for diagnosis of this tumor.…”