Carboxymethylbetaine copolymer layer covalently fixed to a glass substrate

Suzuki, Hisatomo; Li, Lifu; Nakaji-Hirabayashi, Tadashi; Kitano, Hiromi; Ohno, Kohji; Matsuoka, Kazuyoshi; Saruwatari, Yoshiyuki

doi:10.1016/j.colsurfb.2012.01.038

Cited by 17 publications

(18 citation statements)

References 41 publications

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“…In particular, the latter profits from the facile incorporation of reactive groups in special positions, e.g., in the center or at the ends of the polymers, that enable efficient attachment of the macromolecules onto the substrates. Still, classical grafting-from [318][319][320][321][322][323][324][325][326][327][328][329][330][331][332][333][334][335], grafting-to [336][337][338][339][340][341][342][343][344][345][346], and grafting-through [316,347] procedures are of course continuously in use, especially in industrial applications, where the activation of the surfaces for the grafting process by physical means or by simple, "unpretentious" chemistry is preferred for reasons of experience, cost and high-throughput.…”

Section: Synthesis By Chain Growth Polymerizationsmentioning

confidence: 99%

Structures and Synthesis of Zwitterionic Polymers

2014

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Abstract:The structures and synthesis of polyzwitterions ("polybetaines") are reviewed, emphasizing the literature of the past decade. Particular attention is given to the general challenges faced, and to successful strategies to obtain polymers with a true balance of permanent cationic and anionic groups, thus resulting in an overall zero charge. Also, the progress due to applying new methodologies from general polymer synthesis, such as controlled polymerization methods or the use of "click" chemical reactions is presented. Furthermore, the emerging topic of responsive ("smart") polyzwitterions is addressed. The considerations and critical discussions are illustrated by typical examples.

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Section: Synthesis By Chain Growth Polymerizationsmentioning

confidence: 99%

Structures and Synthesis of Zwitterionic Polymers

2014

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“…The glass surface modified with S‐PCMB x showed high hydrophilicity (Table ). Previous studies have shown that immersion of glass plates modified with S‐PCMB x (CMB, 47–90 mol %) in water leads to the gradual development of hydrophilicity and that changes in the contact angle (“air‐in‐water” mode) leveled off after 20 min . This is ascribed to the influence of the unreacted residual silanol groups on the surface wettability.…”

Section: Discussionmentioning

confidence: 99%

“…The adsorption of BSA and the adhesion of fibroblasts (NIH3T3) were investigated using previously reported procedures …”

Section: Methodsmentioning

confidence: 99%

“…Recently, we have prepared a copolymer layer of 1‐carboxy‐ N , N ‐dimethyl‐ N ‐(2‐methacryloyloxyethyl) methanaminium hydroxide inner salt [carboxymethylbetaine (CMB)] and MPTMS with various mixing ratios (47:53–90:10) on a glass substrate . The zwitterionic monomer, CMB, was used because it is easy to synthesize without using toxic chemicals.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of the composition of zwitterionic copolymers for the easy-construction of bio-inactive surfaces

Nishida

Nakaji-Hirabayashi

Kitano

et al. 2016

J. Biomed. Mater. Res.

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Random copolymers (S-PCMBx) of the zwitterionic monomer carboxymethylbetaine (CMB) and a small percentage of 3-methacryloyloxypropyl trimethoxysilane with various composition ratios were synthesized in ethanol using 2,2'-azobisisobutyronitrile as the initiator. An S-PCMBx layer formed on the glass substrate after soaking in the copolymer solution and had a thickness of 2-3 nm. The S-PCMBx-modified surface was highly hydrophilic and suppressed both the non-specific adsorption of protein (bovine serum albumin) and NIH3T3-fibroblast adhesion. The degree of adsorption suppression increased with increasing copolymer CMB content with a maximum at 90 mol % CMB. In contrast, the modification of the glass substrate with a PCMB homopolymer terminally modified with a trimethoxysilyl group did not effectively suppress protein adsorption and cell adhesion due to the low graft density. The importance of balancing the number of fixation points and the length of the zwitterionic polymer loops to produce bio-inactive metal oxide surfaces is suggested. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2029-2036, 2016.

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“…Phosphobetaine, a mimic of the phospholipids of the outer surface of cell membranes, is the very first type of zwitterions ever studied. [13,19] Recently, sulfobetaine and carboxybetaine have attracted an intense interest due to their superior antifouling properties compared with phosphobetaine, and they have been used to functionalize various surfaces such as polymeric membranes, [20][21][22][23][24][25][26][27] silicon/silica, [14,[28][29][30] glass, [29,31,32] gold, [33][34][35] and steel. [36,37] Studies have shown that carboxybetaine may exhibit better anti-adhesion properties than sulfobetaine.…”

Section: Introductionmentioning

confidence: 99%

Novel antifouling surface with improved hemocompatibility by immobilization of polyzwitterions onto silicon via click chemistry

Zheng

Yang

2016

Applied Surface Science

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A novel procedure a novel procedure is presented and demonstrated to develop an antifouling silicon surface with improved hemocompatibility by using a zwitterionic polymer, poly(sulfobetaine methacrylate) (polySBMA). Functionalization of the silicon surface with polySBMA involves the following three steps: (1) an alkyne terminated polySBMA was synthesized by RAFT polymerization; (2) a self-assembled monolayer with bromine end groups was constructed on the silicon surface, and then the bromine end groups were replaced by azide groups; and (3) the polySBMA was attached to the silicon surface by azide-alkyne cycloaddition click reaction. Membrane characterization confirmed a successful silicon surface modification with almost 100% coverage by polySBMA and an extremely hydrophilic surface after such modification. The polySBMA-modified silicon surface was found to have excellent anti-nonspecific adsorption properties for both bovine serum albumin (BSA) protein and model bacterial cells. Whole blood adsorption experiments showed that the polySBMA-modified silicon surface exhibited excellent hemocompatibility and effective anti-adhesion to blood cells. Silicon membranes with such antifouling and hemocompatible surfaces can be advantageously used to, for example, drastically extend the service life of artificial kidney devices.

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Carboxymethylbetaine copolymer layer covalently fixed to a glass substrate

Cited by 17 publications

References 41 publications

Structures and Synthesis of Zwitterionic Polymers

Structures and Synthesis of Zwitterionic Polymers

Optimization of the composition of zwitterionic copolymers for the easy-construction of bio-inactive surfaces

Novel antifouling surface with improved hemocompatibility by immobilization of polyzwitterions onto silicon via click chemistry

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