Carboxymethylations of chitosan and chitin inhibit MMP expression and ROS scavenging in human fibrosarcoma cells

Kong, Chang‐Suk; Kim, Jung-Ae; Ahn, Byul‐Nim; Byun, Hee‐Guk; Kim, Se‐Kwon

doi:10.1016/j.procbio.2009.09.004

Cited by 47 publications

(27 citation statements)

References 34 publications

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“…Treatment with carboxymethyl chitosan suppressed the formation of intracellular reactive oxygen species (ROS), protein oxidation and lipid peroxidation in a concentra-tion-dependent manner. In addition, a protective effect against oxidative damage of the purified genomic DNA was observed in the presence of CM-chitosan [14].…”

Section: (Structure Of Chitosan)mentioning

confidence: 93%

Downregulation of transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (SA-CMC)

Habib¹,

Aggour²,

Taha³

2012

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The present study was conducted to investigate the use of stearic acid-grafted carboxymethyl chitosan(SA-CMC) as a downregulator for trans- forming growth factor-β (TGF- β) and vascular endothelial growth factor (VEGF) in Ehrlich ascites carcinoma (EAC)-bearing mice. The antitumor effect of stearic acid-grafted carboxymethyl chitosan was assessed by the estimation of TGF- β and VEGF in serum in addition to the estimation of tumor volume, median survival time (MST), percentage of increase in life span (ILS%) as well as the contents of total lipid, DNA and RNA in liver tissues. Hematological profiles (hemoglobin, red blood cells, and platelets) were also assessed. In addition, liver function tests and the redox status were estimated. TGF- β, VEGF, DNA, RNA, and malondialdehyde (MDA) levels, in addition to serum alanine transaminase (ALT) and gamma glutamyl transferase (GGT) activities as well as total white blood cells counts and tumor volume were all highly significantly increased (P < 0.001) in untreated EAC-bearing mice compared to controls. However, hematological profiles, total lipid in liver tissues and serum albumin were highly decreased in EAC-bearing mice compared to controls. All these parameters were restored to the normal levels in SA-CMC treated EAC-bearing mice com- pared to the untreated EAC-bearing mice. It is thus concluded that stearic acid-grafted carboxymethyl chitosan has a remarkable antitumor activity against EAC in Swiss albino mice through downregulation of TGF-β and VEGF

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Section: (Structure Of Chitosan)mentioning

confidence: 93%

Downregulation of transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (SA-CMC)

Habib¹,

Aggour²,

Taha³

2012

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“…Several derivatives and synthetic analogues of chitin are currently available that illustrate varied biological activities. One such derivative carboxymethyl-chitin exhibited anti-tumour activity by suppression of MMP-2 and MMP-9 as well as down-regulation of NF-κβ (Nuclear factor-κ β) [66]. It is also reported to be a strong antioxidant.…”

Section: Chitinmentioning

confidence: 99%

Marine Pharmaceuticals: A New Wave of Anti-angiogenic Drugs

Chaugule¹,

Indap²

2018

J Oceanogr Mar Res

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“…Kong et al [15] also investigated the MMP inhibition of chitin, water soluble chitosan and their carboxymethylated derivatives. In the research, chitosan and chitin, carboxymethyl-chitosan (CM-chitosan) and carboxymethyl-chitin (CM-chitin), were synthesized by means of carboxymethylation reaction.…”

Section: Anti-cancer Activity As a Therapeutic Agentmentioning

confidence: 99%

“…These polysaccharides have been widely studied and applied in different fields, Even chitosan is a derivative of chitin it has own unique functions such as support material for gene delivery [11], cell culture [12] and tissue engineering [13,14]. Especially in the biomedical and pharmaceutical industries chitosan and chitosan derivatives have been widely used due to their various biological functions to their various biological functions such as anti-microbial [15], anti-bacterial [16], antioxidant [17] and immunostimulating [18] effects. Besides they have antitumor [19], anti-diabetic [20] and anti-viral [21] activities.…”

Section: Introductionmentioning

confidence: 99%

Anti-Cancer Effects of Chitin and Chitosan Derivatives

Karagozlu

Kim

2014

Handbook of Anticancer Drugs From Marine Origin

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Despite considerable progress in medical research, cancer is still one of the high-ranking causes of death in the world. It is the second most common cause of death due to disease after heart disease and according to World Health Organization it will be cause of death more than 10 million people in 2020. Therefore one of the main research goal for researchers investigating new anticancer agents. But the major complication for the cancer cure without surgeries is side effects. Especially, cytotoxic anti-cancer chemotherapeutic agents generally produce severe side effects, while reducing host resistance to cancer and infections. Therefore, it is important to find new, powerful anti-cancer agents that are highly effective, biodegradable and biocompatible. Chitin and chitosan are biopolymers which have unique structural possibilities for chemical and mechanical modifications to generate novel properties, functions. These biopolymers are biocompatible, biodegradable and non-toxic and their chemical properties allow them easily processed into gels, sponges, membranes, beads and scaffolds forms also. Due to their unique properties, they are excellent candidate for cancer cure or cancer diagnosis.

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Carboxymethylations of chitosan and chitin inhibit MMP expression and ROS scavenging in human fibrosarcoma cells

Cited by 47 publications

References 34 publications

Downregulation of transforming growth factor-<i>β</i> (TGF-<i>β</i>) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (SA-CMC)

Downregulation of transforming growth factor-<i>β</i> (TGF-<i>β</i>) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (SA-CMC)

Marine Pharmaceuticals: A New Wave of Anti-angiogenic Drugs

Anti-Cancer Effects of Chitin and Chitosan Derivatives

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Carboxymethylations of chitosan and chitin inhibit MMP expression and ROS scavenging in human fibrosarcoma cells

Cited by 47 publications

References 34 publications

Downregulation of transforming growth factor-&lt;i&gt;β&lt;/i&gt; (TGF-&lt;i&gt;β&lt;/i&gt;) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (SA-CMC)

Downregulation of transforming growth factor-&lt;i&gt;β&lt;/i&gt; (TGF-&lt;i&gt;β&lt;/i&gt;) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (SA-CMC)

Marine Pharmaceuticals: A New Wave of Anti-angiogenic Drugs

Anti-Cancer Effects of Chitin and Chitosan Derivatives

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Product

Resources

About

Downregulation of transforming growth factor-<i>β</i> (TGF-<i>β</i>) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (SA-CMC)

Downregulation of transforming growth factor-<i>β</i> (TGF-<i>β</i>) and vascular endothelial growth factor (VEGF) in ehrlich ascites carcinoma-bearing mice using stearic acid-grafted carboxymethyl chitosan (SA-CMC)