Carboxymethyl chitosan/clay nanocomposites and their copper complexes: Fabrication and property

Huang, Yong‐Can; Huang, Jun; Cai, Jihai; Lin, Wensheng; Lin, Qixuan; Wu, Fupei; Luo, Jiwen

doi:10.1016/j.carbpol.2015.07.089

Cited by 46 publications

(13 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The protonated amino groups (-NH 3 + ) was neutralized incrementally and ensured the formation of uniform and transparent hydrogels, which avoided the defects of precipitation that could be easily generated by the rapid addition of metal ions. Moreover, since the coordination number reduced from 4 (Cu 2+ ) to 2 (Cu + ) [23,24], the crosslinking density decreased after reduction of Cu 2+ with NaHSO 3 , hence soft CTS-Cu + /NH 3 hydrogels with good shape and transparency were obtained (Figure 1a). Figure 2 shows the FT-IR spectra of the chitosan hydrogels CTS0, CTS22, and CTS26, in which the wide absorption band at ~3500-3200 cm -1 corresponded to the stretching vibration of O-H and N-H.…”

Section: Results and Discussion 31 Formation Of Cts-cu + /Nh 3 Hydrmentioning

confidence: 99%

Cu+-containing physically crosslinked chitosan hydrogels with shape memory

Yu¹,

Li²,

Feng³

et al. 2019

Express Polym. Lett.

View full text Add to dashboard Cite

Physically crosslinked chitosan hydrogels have better biocompatibility and possess unique functional characteristics but suffer from poor mechanical properties. In the current study, we prepared Cu +-containing physically crosslinked chitosan hydrogels by exploiting ammonia fumigation and reduction of Cu 2+ by NaHSO 3. The content of Cu + in the prepared hydrogels was in a low range of 4.88-29.27 μmol/g. The mechanical strength of the CTS-Cu + /NH 3 hydrogels was remarkably improved up to 0.25 MPa and the elongation at break increased with rising content of Cu + due to the dynamic crosslinks between chitosan and Cu +. Moreover, the CTS-Cu + /NH 3 hydrogels demonstrated evident shape memory after exposure to air by exploiting the different coordination number of Cu 2+ and Cu +. Thus, the prepared hydrogels may have good potential applications as biomedical materials.

show abstract

Section: Results and Discussion 31 Formation Of Cts-cu + /Nh 3 Hydrmentioning

confidence: 99%

Cu+-containing physically crosslinked chitosan hydrogels with shape memory

Yu¹,

Li²,

Feng³

et al. 2019

Express Polym. Lett.

View full text Add to dashboard Cite

show abstract

“…CMC not only retains the excellent properties of chitosan but also has stronger water solubility and biological activity [ 13 ]. Chitosan and its derivatives have antibacterial activities against various microorganisms, and its broad-spectrum antibacterial activity has been confirmed by many studies [ 14 , 15 ]. The antioxidant effect of CMC is related to the hydroxyl and carboxyl groups in the polymer chain.…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl chitosan reduces inflammation and promotes osteogenesis in a rabbit knee replacement model

Liu

Wang

et al. 2020

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background The major causes of failure after total knee arthroplasty (TKA) include prosthesis loosening and infection. This study aimed to investigate the role of carboxymethyl chitosan (CMC) in knee arthroplasty. Methods A total of 20 New Zealand white rabbits that were divided into two groups (10 in the control group and 10 in the chitosan group) were included in the study. They underwent TKA surgery, and all were implanted with titanium rod prostheses; the prosthesis in the chitosan group was coated with CMC. After 12 weeks, all rabbits were euthanized, and the following analyses of some specific surface membrane tissues around the prosthesis were performed: X-ray analysis; micro-computed tomography scan; haematoxylin and eosin, Van Gieson, and Von Kossa staining; reverse transcription polymerase chain reaction; and Western Blotting. Results The result of CCK8 test showed CMC can promote cell proliferation and increase cell viability. Radiological result showed better amount of bone deposits and more bone formation in the chitosan group. HE staining result showed CMC reduces inflammation around the prosthesis. The VG and Von Kossa staining results showed CMC can promote bone deposition around prosthesis. And according to the results of PCR and WB, the OCN content was higher in the chitosan group, while the MMPs content was lower. The chitosan group has an increased OPG/RANKL ratio than the control group. Conclusion CMC can effectively inhibit the inflammatory response around the prosthesis and osteoclast activation and promote osteogenesis by interfering with the osteoprotegerin/receptor activator of nuclear factor kappa-Β ligand/receptor activator of nuclear factor kappa-Β signalling pathway.

show abstract

“…Carboxymethyl chitosan (CMC) has recently been introduced. CMC not only retains the excellent properties of chitosan but also has stronger water solubility and biological activity [13].Chitosan and its derivatives have antibacterial activities against various microorganisms, and its broad-spectrum antibacterial activity has been con rmed by many studies [14,15].The antioxidant effect of CMC is related to the hydroxyl and carboxyl groups in the polymer chain.…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl chitosan reduces inflammation and promotes osteogenesis in a rabbit knee replacement model

Liu

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The major causes of failure after total knee arthroplasty (TKA) include prosthesis loosening and infection. This study aimed to investigate the role of carboxymethyl chitosan (CMC) in knee arthroplasty. Methods: A total of 20 New Zealand white rabbits that were divided into two groups (10 in the control group and 10 in the chitosan group) were included in the study. They underwent TKA surgery, and all were implanted with titanium rod prostheses; the prosthesis in the chitosan group was coated with CMC. After 12 weeks, all rabbits were euthanized, and the following analyses of some specific surface membrane tissues around the prosthesis were performed: X-ray analysis; micro-computed tomography scan; haematoxylin and eosin, Van Gieson, and Von Kossa staining; reverse transcription polymerase chain reaction; and Western Blotting. Results: The result of CCK8 test showed CMC can promote cell proliferation and increase cell viability. Radiological result showed better amount of bone deposits and more bone formation in the chitosan group. HE staining result showed CMC reduces inflammation around the prosthesis. The VG and Von Kossa staining results showed CMC can promote bone deposition around prosthesis. And according to the results of PCR and WB, the OCN content was higher in the chitosan group, while the MMPs content was lower. The chitosan group has an increased OPG/RANKL ratio than the control group.Conclusion: CMC can effectively inhibit the inflammatory response around the prosthesis and osteoclast activation and promote osteogenesis by interfering with the osteoprotegerin/receptor activator of nuclear factor kappa-Β ligand/receptor activator of nuclear factor kappa-Β signalling pathway.

show abstract

Carboxymethyl chitosan/clay nanocomposites and their copper complexes: Fabrication and property

Cited by 46 publications

References 38 publications

Cu+-containing physically crosslinked chitosan hydrogels with shape memory

Cu+-containing physically crosslinked chitosan hydrogels with shape memory

Carboxymethyl chitosan reduces inflammation and promotes osteogenesis in a rabbit knee replacement model

Carboxymethyl chitosan reduces inflammation and promotes osteogenesis in a rabbit knee replacement model

Contact Info

Product

Resources

About