Carboxymethyl Cellulose-Based Hydrogel: Dielectric Study, Antimicrobial Activity and Biocompatibility

Turky, Gamal; Moussa, M. A.; Hasanin, Mohamed S.; El-Sayed, Naglaa Salem; Kamel, Samir

doi:10.1007/s13369-020-04655-8

Cited by 40 publications

(17 citation statements)

References 41 publications

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“…The antimicrobial groups present in the AMPS polymer (i.e., acrylamide groups) prevent the hydrogel from being attacked by surrounding bacteria. The addition of AA and the AMPS co-polymer to the hydrogel leads to a reduced pH value, which causes stress on the bacterial cells, disrupting the cells’ homeostasis [ 31 , 32 ] prepared carboxymethyl cellulose-g-poly (acrylamide-co-acryl amido-2-methyl-1-propane sulfonic acid) hydrogels. Their sample showed the lowest efficiency as an antimicrobial agent, and they improved the antimicrobial activity of the hydrogel by the addition of silver nanoparticles [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis of a Cellulose-Co-AMPS Hydrogel for Personal Hygiene Applications Using Cellulose Extracted from Corncobs

Enawgaw

Tesfaye

Yilma

et al. 2021

Gels

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Cellulose-based hydrogels were prepared by the extraction of cellulose from corncobs after the removal of lignin and hemicellulose with the use of alkali–acid treatment. Acrylate-based hydrogels presently available for personal hygiene uses are not biodegradable. In this study, a biodegradable cellulose-co-AMPS personal hygiene hydrogel was synthesized. The hydrogel was synthesized by graft co-polymerization of 2-acrylamido2-methyl propane sulfonic acid onto corncob cellulose by using potassium persulfate (KPS) as an initiator and borax decahydrate (Na2B4O7·10H2O) as a cross-linking agent. Structural and functional characteristics of the hydrogel such as swelling measurements, antimicrobial tests, FTIR spectra and thermogravimetric analysis were done. The hydrogel showed an average swelling ratio of 279.6 g/g to water and 83.3 g/g to a urine solution with a 97% gel fraction. The hydrogel displayed no clear inhibition zone and did not support the growth of bacteria, Gram-positive or -negative. The FT-IR spectra of the hydrogel confirmed the grafting of an AMPS co-polymer onto cellulose chains. The thermal properties of the hydrogel showed three-step degradation, with a complete degradation temperature of 575 °C.

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Section: Resultsmentioning

confidence: 99%

Synthesis of a Cellulose-Co-AMPS Hydrogel for Personal Hygiene Applications Using Cellulose Extracted from Corncobs

Enawgaw

Tesfaye

Yilma

et al. 2021

Gels

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“…The lack of cytotoxicity here observed has been previously described in the literature, as CMC in its various forms has been described as being non-cytotoxic against a variety of cell lines. For instance, CMC hydrogels have been shown to be safe towards human osteosarcoma-derived cells, HaCaT, primary mouse embryonic fibroblast, L929 mouse fibroblasts, and Vero cell line [6,[34][35][36][37][38]. Similarly, CMC scaffolds for tissue engineering showed no cytotoxicity toward L929 cells, human chondrocytes, and osteosarcoma cells [9,[39][40][41] and CMC nanostructures are safe toward fibroblasts, HEK293T, and HaCaT cells [42,43].…”

Section: Cytotoxicity Evaluationmentioning

confidence: 99%

Characterization and Evaluation of Commercial Carboxymethyl Cellulose Potential as an Active Ingredient for Cosmetics

et al. 2022

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Carboxymethyl cellulose is the most used water-soluble cellulose with applications in industries such as food, cosmetics, and tissue engineering. However, due to a perceived lack of biological activity, carboxymethyl cellulose is mostly used as a structural element. As such, this work sought to investigate whether CMC possesses relevant biological properties that could grant it added value as a cosmeceutical ingredient in future skincare formulations. To that end, CMC samples (Mw between 471 and 322 kDa) skin cell cytotoxicity, impact upon pro-collagen I α I production, and inflammatory response were evaluated. Results showed that samples were not cytotoxic towards HaCat and HDFa up to 10 mg/mL while simultaneously promoting intracellular production of pro-collagen I α I up by 228% relative to the basal metabolism, which appeared to be related to the highest DS and Mw. Additionally, CMC samples modulated HaCat immune response as they decreased by ca. 1.4-fold IL-8 production and increased IL-6 levels by ca. five fold. Despite this increase, only two samples presented IL-6 levels similar to those of the inflammation control. Considering these results, CMC showed potential to be a more natural alternative to traditional bioactive cosmetic ingredients and, as it is capable of being a bioactive and structural ingredient, it may play a key role in future skincare formulations.

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“…For measuring cellular growth, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) was used, and its yellow color changed to purple formazan in the mitochondria of living cells. [26] Dimethyl sulfoxide was added to dissolve the insoluble purple formazan product into a colored solution.…”

Section: Cytotoxicity Evaluation Using Viability Assaymentioning

confidence: 99%

Hydroxypropyl methylcellulose/graphene oxide composite as drug carrier system for 5‐fluorouracil

Hasanin

El-Sakhawy

Ahmed

et al. 2022

Biotechnology Journal

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Aim: This study aims to prepare a nanocomposite (HPMC/5-FL@GO) from hydroxypropyl methylcellulose (HPMC) and graphene oxide (GO) as biocompatible materials.The nanocomposite enhances the drug activity of immobilized 5-fluorouracil (5-FU), decreasing the side effect of long-run treatment protocols with highly efficient drugdrug activity.Method and results: Different samples were characterized by ATR-FTIR spectroscopy, X-ray diffraction, scanning electron microscopy coupled with energy dispersive X-ray analysis, transmission electron microscopy, thermogravimetric analysis, and dynamic light scattering along with cytotoxicity and anticancer study. A homogenous and compatible nanocomposite structure with a homogenous drug distribution was confirmed.Furthermore, the prepared nanocomposite has a low cytotoxicity effect against normal Vero cell lines compared with 5-FU. The antitumor activities of the same nanocomposite (20.4 and 74.3 μg mL −1 on A549 and HepG-2) were lower than that of 5-FU (54.1 and 103 μg mL −1 on A549 and HepG-2). Conclusion and implications:According to the attained results, the HPMC/5-FL@GO can apply in a biomedical application such as cancer therapy with the unique biocompatible to human cells.

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Carboxymethyl Cellulose-Based Hydrogel: Dielectric Study, Antimicrobial Activity and Biocompatibility

Cited by 40 publications

References 41 publications

Synthesis of a Cellulose-Co-AMPS Hydrogel for Personal Hygiene Applications Using Cellulose Extracted from Corncobs

Synthesis of a Cellulose-Co-AMPS Hydrogel for Personal Hygiene Applications Using Cellulose Extracted from Corncobs

Characterization and Evaluation of Commercial Carboxymethyl Cellulose Potential as an Active Ingredient for Cosmetics

Hydroxypropyl methylcellulose/graphene oxide composite as drug carrier system for 5‐fluorouracil

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