Carboxyl-functionalized derivatives of carboxymethyl cellulose: towards advanced biomedical applications

Pettignano, Asja; Charlot, Aurélia; Fleury, Étienne

doi:10.1080/15583724.2019.1579226

Cited by 74 publications

(51 citation statements)

References 149 publications

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“…Unlike other review articles, here we have shown, together with the various roles of CMC in pharmaceutical applications such as binders, emulsifiers, film-forming components, reliable carriers including special property such as pH sensitive ( Figure 8 a) [ 341 ], thermosensitive ( Figure 8 b) [ 347 ], multidrug resistive ( Figure 8 c) [ 338 ], etc., in oral, injection, or other drug delivery systems. Additionally, their characteristics as demonstrated for use as an excipient in pharmaceuticals have been summarized in the Supplementary Materials (Table S5) .…”

Section: Application Of Cmcmentioning

confidence: 62%

Recent Developments of Carboxymethyl Cellulose

et al. 2021

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Carboxymethyl cellulose (CMC) is one of the most promising cellulose derivatives. Due to its characteristic surface properties, mechanical strength, tunable hydrophilicity, viscous properties, availability and abundance of raw materials, low-cost synthesis process, and likewise many contrasting aspects, it is now widely used in various advanced application fields, for example, food, paper, textile, and pharmaceutical industries, biomedical engineering, wastewater treatment, energy production, and storage energy production, and storage and so on. Many research articles have been reported on CMC, depending on their sources and application fields. Thus, a comprehensive and well-organized review is in great demand that can provide an up-to-date and in-depth review on CMC. Herein, this review aims to provide compact information of the synthesis to the advanced applications of this material in various fields. Finally, this article covers the insights of future CMC research that could guide researchers working in this prominent field.

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Section: Application Of Cmcmentioning

confidence: 62%

Recent Developments of Carboxymethyl Cellulose

et al. 2021

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“…Natural polysaccharides are attractive options for the formulation of ocular medications, as these polysaccharides are economical, readily available, non-toxic, potentially biodegradable, generally biocompatible, and typically amenable to chemical modifications [8][9][10][11][12][13]. Indeed, chemical modifications have recently led to derivatives with improved properties in terms of rheology, mucoadhesion, increased ocular retention, and drug solubilization [14][15][16][17][18].…”

Section: Polysaccharides Used In Ophthalmologymentioning

confidence: 99%

Polysaccharides in Ocular Drug Delivery

et al. 2019

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Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.

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“…The presence of the carboxymethyl functions distributed along the polymer backbone confers to this derivative an increased reactivity and solubility in water, with respect to unmodified cellulose. Up to now, this reactivity has been mainly employed to modify NaCMC, by introduction of ester or amide functions, in homogeneous aqueous medium and in presence of carbodiimides as coupling agents [10]. Nevertheless, the lack of solubility of CMC in organic solvents, under both its sodium salt (NaCMC) and acid (HCMC) form, significantly limits its derivatization by grafting of hydrophobic molecules.…”

Section: Introductionmentioning

confidence: 99%

Solvent-Free Synthesis of Amidated Carboxymethyl Cellulose Derivatives: Effect on the Thermal Properties

2019

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The present work explores the possibility of chemically modifying carboxymethyl cellulose (CMC), a widely diffused commercial cellulose ether, by grafting of hydrophobic moieties. Amidation of CMC, at high temperature and in heterogeneous conditions, was selected as synthetic tool for grafting on CMC a panel of commercially available amines (bearing long aliphatic chains, alkyl aromatic and heteroaromatic groups, more or less spaced from the cellulose backbone). The reaction was successfully carried out in absence of solvents, catalysts and coupling agents, providing a promising and more sustainable alternative to conventional amidation procedures. Relationships between the chemical structure of the obtained CMC derivatives and their thermal properties were carefully studied, with a particular attention to the thermal behavior. Grafting of aromatic and heteroaromatic alkyl amines, presenting a linear alkyl chain between CMC backbone and a terminal bulky moiety, allowed for efficiently separating the polysaccharide chains, improving their mobility and resulting in a consequent lowering of the glass transition temperature (Tg). The Tg values obtained (90–147 °C) were found to be closely dependent on both the size of the aliphatic spacer, the structure of the aromatic ring and the extent of amidation.

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Carboxyl-functionalized derivatives of carboxymethyl cellulose: towards advanced biomedical applications

Cited by 74 publications

References 149 publications

Recent Developments of Carboxymethyl Cellulose

Recent Developments of Carboxymethyl Cellulose

Polysaccharides in Ocular Drug Delivery

Solvent-Free Synthesis of Amidated Carboxymethyl Cellulose Derivatives: Effect on the Thermal Properties

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