Carboxyl Enriched Monodisperse Porous Fe₃O₄ Nanoparticles with Extraordinary Sustained-Release Property

Abstract

Carboxyl-enriched monodisperse porous Fe3O4 nanoparticles with diameters of about 85-nm have been synthesized via a simple hydrothermal method. The porous structure of the product is confirmed further by transmission electron microscopy (TEM) observation and nitrogen sorption measurement with a Brunauer-Emmett-Teller (BET) surface area about 36.61 m2/g. An IR spectrum of the sample identifies that abundant carboxylate groups are formed on the surface of the nanoparticles as well as the pore surface. Because of the confined effect of the nanochannels in the nanoparticles and carboxyl-functionalized Fe3O4 nanoparticles, and the strong interaction between ibuprofen and COO-, as-prepared porous nanoparticles show a more extraordinary sustained-release property than that of hollow silica nanoparticles in vitro. This result suggests that as-prepared porous nanoparticles can also be used for the targeted delivery of other aromatic acid drugs.

Adsorption of Bismarck Brown by Iron Oxide Nanosphere and Its Modified Form

“…[1] Different morphologies of iron oxide such as wires, [2] flower-shaped, [3] hollow sphere, [4] nanoparticle, [5] nanocubes, [6] and nanosphere [7] have been fabricated by various methods. [7][8][9][10] The iron oxide with low toxicity, biocompatibility, and high curie temperature [10] has wide applications in biomedical engineering, [11] biosensor development, [12] drug delivery, [13] and other developing fields.…”

Highly Porous, Water‐Soluble, Superparamagnetic, and Biocompatible Magnetite Nanocrystal Clusters for Targeted Drug Delivery

“…This value is not only much higher than the one of the dense particles but also much higher than the one for magnetite hollow spheres. [13,31,32] This is mainly due to the generation of ammonia gas from ammonium acetate hydrolysis in the system. Increasing the ammonium acetate amount generated more ammonia gas and made the porosity become higher.…”

Hollow Magnetic Nanoparticles: Synthesis and Applications in Biomedicine

“…79 Multiple-responses composites particles synthesis will be the current trend which could expand the scope of the magnetic hollow nanoparticles application. 80 But one of the major disadvantages of hollow magnetic nanoparticles for drug delivery application is to synthesize of specific magnetic hollow particles by all kinds of approaches and simultaneously controlled and tuned shape and size of final particles. Meanwhile, the toxicity for cell and tissue remained to be further identified.…”