Carboxyhemoglobin – the forgotten parameter of neonatal hyperbilirubinemia

Bailey, Douggl G N; Hentschel, Roland

doi:10.1515/jpm-2016-0053

Cited by 12 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carboxyhemoglobin (COHb) has been identified as a potential marker of hemolysis in other conditions such as neonatal hyperbilirubinemia due to hemolysis. 8,9 COHb is produced when exogenous carbon monoxide (CO) binds to hemoglobin. [10][11][12] However, it is also produced during the normal catabolism and degradation of hemoglobin.…”

Section: Introductionmentioning

confidence: 99%

Carboxyhemoglobin levels in children during extracorporeal membrane oxygenation support: a retrospective study

et al. 2021

View full text Add to dashboard Cite

Introduction: Hemolysis is a common complication of extracorporeal membrane oxygenation (ECMO). There are few data on whether carboxyhemoglobin (COHb), a potential marker of hemolysis, are elevated during ECMO support. Methods: We conducted a single-center, retrospective study comparing peak COHb levels of children pre-, during, and post-ECMO from January 2017 to August 2020. Results: There were 154 ECMO runs in 147 children (154 PICU admissions) included in the study. The median age was 3.5 (IQR 0.2, 39.2) months. Veno-arterial ECMO was the predominant mode: 146/154 (94.8%). Eighty-seven children (56.5%) underwent cardiac surgery. Peak COHb levels during ECMO were statistically significantly higher compared to pre ECMO (COHb 1.8% (IQR 1.4, 2.6) vs COHb 1.2% (IQR 0.7, 1.7), p < 0.001) and post ECMO (COHb 1.6% (IQR 1.3, 2.2), p = 0.009). Children with COHb ⩾2% were younger and had longer duration of ECMO support. Plasma hemoglobin weakly correlated with COHb level ( r = 0.14; p = 0.04). Conclusions: Carboxyhemoglobin levels increased during ECMO support compared to the pre and post ECMO period. Younger age and longer ECMO duration were associated with COHb levels ⩾2%. Plasma hemoglobin weakly correlated with COHb level.

show abstract

Section: Introductionmentioning

confidence: 99%

Carboxyhemoglobin levels in children during extracorporeal membrane oxygenation support: a retrospective study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Heme-CO, such as carboxyhemoglobin (COHb), therefore reflects endogenous CO production and represents the main storage form of CO in the body (Figure 4). It has been suggested that COHb might be useful as a marker for high hemoglobin turnover to allow an earlier identification of newborns at risk of hyperbilirubinemia [92]. Moreover, COHb levels during the early postnatal period may serve as a practical marker for subsequent development of bronchopulmonary dysplasia, a disease associated with increased CO production [93,94].…”

Section: Carbon Monoxidementioning

confidence: 99%

The role of gasotransmitters in neonatal physiology

2020

View full text Add to dashboard Cite

The gasotransmitters, nitric oxide (NO), hydrogen sulfide (H 2 S), and carbon monoxide (CO), are endogenously-produced volatile molecules that perform signaling functions throughout the body. In biological tissues, these small, lipid-permeable molecules exist in free gaseous form for only seconds or less, and thus they are ideal for paracrine signaling that can be controlled rapidly by changes in their rates of production or consumption. In addition, tissue concentrations of the gasotransmitters are influenced by fluctuations in the level of O 2 and reactive oxygen species (ROS). The normal transition from fetus to newborn involves a several-fold increase in tissue O 2 tensions and ROS, and requires rapid morphological and functional adaptations to the extrauterine environment. This review summarizes the role of gasotransmitters as it pertains to newborn physiology. Particular focus is given to the vasculature, ventilatory, and gastrointestinal systems, each of which uniquely illustrate the function of gasotransmitters in the birth transition and newborn periods. Moreover, given the relative lack of studies on the role that gasotransmitters play in the newborn, particularly that of H 2 S and CO, important gaps in knowledge are highlighted throughout the review.

show abstract

“…Higher concentration might indicate that the mother smoked during pregnancy. COHb value rises in a neonate's blood during the first days after delivery and partially correlates with total serum bilirubin concentration, especially for values below 15 mg/dl [57].…”

Section: Carbon Monoxide: Another Relevant Playermentioning

confidence: 99%

Two Faces of Heme Catabolic Pathway in Newborns: A Potential Role of Bilirubin and Carbon Monoxide in Neonatal Inflammatory Diseases

Osiak

Wątroba²,

Kapka‐Skrzypczak

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

In an infant’s body, all the systems undergo significant changes in order to adapt to the new, extrauterine environment and challenges which it poses. Fragile homeostasis can be easily disrupted as the defensive mechanisms are yet imperfect. The activity of antioxidant enzymes, i.e., superoxide dismutase, catalase, and glutathione peroxidase, is low; therefore, neonates are especially vulnerable to oxidative stress. Free radical burden significantly contributes to neonatal illnesses such as sepsis, retinopathy of premature, necrotizing enterocolitis, bronchopulmonary dysplasia, or leukomalacia. However, newborns have an important ally—an inducible heme oxygenase-1 (HO-1) which expression rises rapidly in response to stress stimuli. HO-1 activity leads to production of carbon monoxide (CO), free iron ion, and biliverdin; the latter is promptly reduced to bilirubin. Although CO and bilirubin used to be considered noxious by-products, new interesting properties of those compounds are being revealed. Bilirubin proved to be an efficient free radicals scavenger and modulator of immune responses. CO affects a vast range of processes such as vasodilatation, platelet aggregation, and inflammatory reactions. Recently, developed nanoparticles consisting of PEGylated bilirubin as well as several kinds of molecules releasing CO have been successfully tested on animal models of inflammatory diseases. This paper focuses on the role of heme metabolites and their potential utility in prevention and treatment of neonatal diseases.

show abstract

Carboxyhemoglobin – the forgotten parameter of neonatal hyperbilirubinemia

Abstract: COHb might be useful as a marker for high hemoglobin turnover to allow an earlier identification of newborns at risk to a rapid rise in bilirubin.

Cited by 12 publications

References 29 publications

Carboxyhemoglobin levels in children during extracorporeal membrane oxygenation support: a retrospective study

Carboxyhemoglobin levels in children during extracorporeal membrane oxygenation support: a retrospective study

The role of gasotransmitters in neonatal physiology

Two Faces of Heme Catabolic Pathway in Newborns: A Potential Role of Bilirubin and Carbon Monoxide in Neonatal Inflammatory Diseases

Contact Info

Product

Resources

About