Carboxyhemoglobin Half-life in Carbon Monoxide-Poisoned Patients Treated With 100% Oxygen at Atmospheric Pressure

Weaver, Lindell K.; Howe, S; Hopkins, Ramona O.; Chan, Karen J.

doi:10.1378/chest.117.3.801

Cited by 208 publications

(150 citation statements)

References 12 publications

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“…Under normobaric conditions and breathing room air, the half-life of HgCO is approximately 320 minutes [64], when administering normobaric 100% oxygen, the half-like is approximate 80 minutes [65]. When 100% oxygen is administered under greater than atmospheric pressure (i.e.…”

Section: Treatmentmentioning

confidence: 99%

Neurologic and Pregnancy Effects of Carbon Monoxide Exposure

Bird¹

2017

Toxicol Open Access

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Carbon monoxide exposure remains a public health concern worldwide. Despite the burden that carbon monoxide exerts, significant controversy exists regarding optimal treatment of exposed persons. Particular controversy exists around neurologic effects of carbon monoxide exposure, how best to evaluate for neurocognitive dysfunction, and effects on the fetus of pregnant women. This review focuses on the mechanism of injury from carbon monoxide, and summarizes the data regarding neurocognitive dysfunction and fetal effects of exposure.

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Section: Treatmentmentioning

confidence: 99%

Neurologic and Pregnancy Effects of Carbon Monoxide Exposure

Bird¹

2017

Toxicol Open Access

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“…Previous studies have focused on patients exposed to CO in high concentrations, including fire victims (Weaver, Howe, Hopkins, & Chan, 2000) or after inhaling CO (Kreck, Shade, Lamm, McKinney, & Hlastala, 2001;Sasaki, 1975;Shimazu et al, 2000;Wagner, Horvath, & Dahms, 1975;Wazawa, Yamamoto, Yamamoto, Matsumoto, & Fukui, 1996). These studies often had a high start dose of CO and they examined best means of elimination of CO.…”

Section: Kinetics Of Carbon Monoxidementioning

confidence: 99%

“…The elimination pattern for CO has not been fully elucidated either. Some have claimed that CO follows first orders kinetics with one compartmental elimination (Kreck et al, 2001;Sasaki, 1975;Weaver et al, 2000), while others speculate that it has second or multi-compartmental elimination (Shimazu et al, 2000;Wagner et al, 1975); (Wazawa et al, 1996). In a population pharmacokinetic study investigating the elimination time for CO in smokers, the results showed twocompartmental kinetics with a half-life of 1.6 h for the first phase and 30.9 h for the second phase (Cronenberger, Mould, Roethig, & Sarkar, 2007).…”

Section: Kinetics Of Carbon Monoxidementioning

confidence: 99%

Carbon monoxide in biological systems: an experimental and clinical study

Åberg¹

2008

Acta Anaesthesiol Scand

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“…Previous studies have described patients in whom carbon monoxide exposure was high (5-82%), in fire victims (Weaver et al, 2000) or from inhalation of carbon monoxide (Kreck et al, 2001;Sasaki, 1975;Shimazu et al, 2000;Wazawa et al, 1996;Wagner et al, 1975). The aim of such studies was to investigate which factors influence the elimination of carbon monoxide and to find the best ventilation for the elimination.…”

Section: Introductionmentioning

confidence: 99%

“…Elimination half-life varied significantly (5-190 minutes). Some investigators concluded that carbon monoxide elimination follows first orders kinetics (Kreck et al, 2001;Sasaki, 1975;Weaver et al, 2000) whereas others state it is of second order (Shimazu et al, 2000;Wagner et al, 1975). In one study it was concluded that carbon monoxide is eliminated according to third orders kinetics (Wazawa et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Circulatory effects and kinetics following acute administration of carbon monoxide in a porcine model

et al. 2004

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Carbon monoxide is produced in the endothelial cells and has possible vasodilator activity through three different pathways. The aim of this study was to demonstrate circulatory effects after administration of saturated carbon monoxide blood and to describe the pharmacokinetics of carbon monoxide. Six pigs were anesthetized and 150 ml blood was removed. This blood was bubbled with carbon monoxide until the carboxyhemoglobin (COHb) levels were 90-99%. A specific amount of this blood was then injected back to the animal. At predetermined times; arterial and mixed venous blood was drawn and analyzed for carbon monoxide. Systemic and pulmonary vascular resistance index (SVRi and PVRi) were measured and exhaled air was sampled and measured for carbon monoxide. Blood samples were gathered over 300 minutes along with measurements of invasive pressures, heart rate, cardiac output, oxygen saturation (SpO 2 ), Hb, temperature and blood gases. We conclude that this type of exposure to carbon monoxide appears to have little or no effect on general vasomotor tone and, after correcting for basal levels of carbon monoxide, elimination occurs through the lungs as predicted by a single compartment model. The half-life of carbon monoxide was determined to be 60.5 minutes (SEM 4.7).

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Carboxyhemoglobin Half-life in Carbon Monoxide-Poisoned Patients Treated With 100% Oxygen at Atmospheric Pressure

Cited by 208 publications

References 12 publications

Neurologic and Pregnancy Effects of Carbon Monoxide Exposure

Neurologic and Pregnancy Effects of Carbon Monoxide Exposure

Carbon monoxide in biological systems: an experimental and clinical study

Circulatory effects and kinetics following acute administration of carbon monoxide in a porcine model

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