Carboxyamido-triazole inhibits proliferation of human breast cancer cells via G2/M cell cycle arrest and apoptosis

Study on the role of transient receptor potential C6 channels in esophageal squamous cell carcinoma radiosensitivity

“…Ca 2+ channel is the most compressive channel located on cell membrane (14). The abnormal expression of Ca 2+ channel was found in more tumor tissues and cells (15)(16)(17). The high expression of Ca 2+ channel in tumor may induce cellular proliferation, apoptosis dysfunction or cell migration, while lower expression or none was found in normal cells (18)(19)(20)(21).…”

Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer

“…The Ca 2+ channels, through which the [Ca 2+ ] i can be regulated, also have critical roles in tumour development 10. For example, inhibition of a voltage-independent Ca 2+ channel induces growth inhibition and apoptosis in breast cancer cells 11. Moreover, expression and activation of the channels in the transient receptor potential (TRP) superfamily are found in different cancers 12…”

Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency

“…16,25 We found that CAI, up to 10 lM, has a selective antiproliferative and antiinvasive effects on DNA MMR-deficient cancer cells. One of the explanations as D'Amato et al 26 suggested is that CAI decreases intracellular calcium concentration interacting with E-selectin receptor starts signal transduction pathways that affect cell spreading, tyrosine phosphorylation signaling and cancer cell motility.…”

“…Apart from a well-documented cytostatic effect, CAI also has a cytocidal function and induces apoptosis in several human tumor cells. [15][16][17] CAI unlike high-dose nifedipine is better suited for clinical use, and it has been well studied in phase I and phase II trials.…”