Carbostyril derivatives: Synthesis of novel carbostyril-3′-carbonitrilselenophene hybrid compounds and investigation of their antiproliferative properties on prostate and breast cancer

Erşatır, Mehmet; Yıldırım, Metin; Giray, Elife Sultan

doi:10.1080/00397911.2020.1825744

Cited by 9 publications

(2 citation statements)

References 22 publications

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“…The significance of coumarin-selenophene derivatives shows antiproliferative activity against prostate cancer [31]. The cytotoxicity of coumarin and coumarin-selenophene derivatives was determined by xCELLigence system.…”

Section: Antiproliferative Activitymentioning

confidence: 99%

Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer

et al. 2021

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3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate were converted into coumarinselenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by NMR. The prepared compounds are screened for their anticancer activity against to DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines.

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Section: Antiproliferative Activitymentioning

confidence: 99%

Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer

et al. 2021

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“…The cyanopyridine scaffold has been discovered to possess a variety of bioactivities, including anti‐inflammatory, antibacterial and anticancer properties. [ 21–25 ] Cyanopyridine‐based derivatives showed various enzyme inhibition activities [ 26–30 ] including EGFR [ 31,32 ] and CA. [ 33–35 ] Among these derivatives, compound I has an IC 50 value of 0.6 μM on EGFR [ 32 ] and compound II showed good EGFR inhibition with an IC 50 value of 0.203 μM.…”

Section: Introductionmentioning

confidence: 99%

Identification of 3‐(5‐cyano‐6‐oxo‐pyridin‐2‐yl)benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity

Shaldam,

Khalil,

Almahli

et al. 2023

Archiv der Pharmazie

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New 5‐cyano‐6‐oxo‐pyridine‐based sulfonamides (6a–m and 8a–d) were designed and synthesized to potentially inhibit both the epidermal growth factor receptor (EGFR) and carbonic anhydrase (CA), with anticancer properties. First, the in vitro anticancer activity of each target substance was tested using Henrietta Lacks cancer cell line and M.D. anderson metastasis breast cancer cell line cells. Then, the possible CA inhibition against the human CA isoforms I, II, and IX was investigated, together with the EGFR inhibitory activity, with the most powerful derivatives. The neighboring methoxy group may have had a steric effect on the target sulfonamides, which prevented them from effectively inhibiting the CA isoforms while effectively inhibiting the EGFR. The effects of the 5‐cyanopyridine derivatives 6e and 6l on cell‐cycle disruption and the apoptotic potential were then investigated. To investigate the binding mechanism and stability of the target molecules, thorough molecular modeling assessments, including docking and dynamic simulation, were performed.

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Recent advances on biologically active coumarin-based hybrid compounds

2023

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Carbostyril derivatives: Synthesis of novel carbostyril-3′-carbonitrilselenophene hybrid compounds and investigation of their antiproliferative properties on prostate and breast cancer

Cited by 9 publications

References 22 publications

Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer

Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer

Identification of 3‐(5‐cyano‐6‐oxo‐pyridin‐2‐yl)benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity

Recent advances on biologically active coumarin-based hybrid compounds

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