Carborane RAFT agents as tunable and functional molecular probes for polymer materials

Messina, Marco S.; Graefe, Christian T.; Chong, P. Andrew; Ebrahim, Omar M.; Pathuri, Ramya S.; Bernier, Nicholas A.; Mills, Harrison A.; Rheingold, Arnold L.; Frontiera, Renee R.; Maynard, Heather D.; Spokoyny, Alexander M.

doi:10.1039/c9py00199a

Cited by 14 publications

(14 citation statements)

References 88 publications

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“…[110,111] Although there exist many examples of generating polymers through RAFT with bioactive functionality either at the end of the polymer or as pendant groups, this section of the review will only cover peptide-, protein-, and nucleic acid-polymer conjugates by grafting-from using RAFT. [112][113][114][115][116]…”

Section: Electrochemical Atrp (Eatrp)mentioning

confidence: 99%

Preparation of biomolecule-polymer conjugates by grafting-from using ATRP, RAFT, or ROMP

Messina

Bhattacharya

et al. 2020

Progress in Polymer Science

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Biomolecule-polymer conjugates are constructs that take advantage of the functional or otherwise beneficial traits inherent to biomolecules and combine them with synthetic polymers possessing specially tailored properties. The rapid development of novel biomolecule-polymer conjugates based on proteins, peptides, or nucleic acids has ushered in a variety of unique materials, which exhibit functional attributes including thermo-responsiveness, exceptional stability, and specialized specificity. Key to the synthesis of new biomolecule-polymer hybrids is the use of controlled polymerization techniques coupled with either grafting-from, grafting-to, or grafting-through methodology, each of which exhibit distinct advantages and/or disadvantages. In this review, we present recent progress in the development of biomolecule-polymer conjugates with a focus on works that have detailed the use of grafting-from methods employing ATRP, RAFT, or ROMP.

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Section: Electrochemical Atrp (Eatrp)mentioning

confidence: 99%

Preparation of biomolecule-polymer conjugates by grafting-from using ATRP, RAFT, or ROMP

Messina

Bhattacharya

et al. 2020

Progress in Polymer Science

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147

102

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“…In the case of biological samples, using small Raman tags that vibrate in the “cell silent region” (∼1800–2800 cm –1 ) can allow otherwise undetectable analytes to be tracked. Examples of these include alkynes, nitriles, and B–H and C–D stretches. , While in these cases, the technique is not truly label-free, these vibrational tags cannot bleach and are smaller than fluorescent dye molecules and much smaller than fluorescent proteins, making them less likely to cause unwanted perturbations. Multiplexing is also easier with vibrational tags than with fluorescent tags due to their narrower peak bandwidths.…”

Section: Discussionmentioning

confidence: 99%

Far-Field Super-Resolution Vibrational Spectroscopy

et al. 2019

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important to note that since most of the represented in 1 is proof-of-concept, acquisition times and power values may differ significantly when these techniques are applied to actual systems of interest. For example, Choi et al. point out that a depletion power of 2 TW cm −2 is incompatible with biological material. However, less efficient depletion will still allow them to see improvements in resolution. 63 The results and simulations discussed here represent promising steps toward this goal and toward offering alternative microscopy options to fluorescence-based methods.

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“…Access to the novel structures described herein is made possible by an unconventional aromatic organoborane monomer. The incorporation of main group elements into polymeric materials is an active area of research yielding new insights relevant to optoelectronics, material properties, and biology. − …”

Section: Discussionmentioning

confidence: 99%

Organoborane Strategy for Polymers Bearing Lactone, Ester, and Alcohol Functionality

Zhou

Wouw

et al. 2019

Macromolecules

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Vinyl alcohol–methacrylatecopolymers have intriguing functionally rich structures but are synthetically inaccessible from vinyl acetate, the traditional precursor to polyvinyl alcohol. We report a solution via BN 2-vinylnaphthalene (BN2VN), an aromatic vinyl borane monomer. Conventional free radical copolymerization of BN2VN and methyl methacrylate (MMA) is facile. Conversion of BN2VN side chains to VA side chains is accomplished in organic solvents with Me3NO·2H2O and avoids MMA hydrolysis. The VA–MMA copolymer rapidly lactonizes to give an unprecedented macromolecule bearing both acyclic and cyclic ester residues. Methanolysis furnishes the statistical copolymer bearing vinyl alcohol, methyl methacrylate, and lactone residues. tert-Butyl methacrylate-BN2VN copolymers were shown to not lactonize.

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Carborane RAFT agents as tunable and functional molecular probes for polymer materials

Abstract: Carborane RAFT agents are introduced as tunable multi-purpose tools acting as 1H NMR spectroscopic handles, Raman probes, and recognition units.

Cited by 14 publications

References 88 publications

Preparation of biomolecule-polymer conjugates by grafting-from using ATRP, RAFT, or ROMP

Preparation of biomolecule-polymer conjugates by grafting-from using ATRP, RAFT, or ROMP

Far-Field Super-Resolution Vibrational Spectroscopy

Organoborane Strategy for Polymers Bearing Lactone, Ester, and Alcohol Functionality

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