Carbopol gel containing chitosan-egg albumin nanoparticles for transdermal aceclofenac delivery

Jana, Sougata; Manna, Sreejan; Nayak, Amit Kumar; Sen, Kalyan Kumar; Basu, S.

doi:10.1016/j.colsurfb.2013.09.045

Cited by 201 publications

(89 citation statements)

References 22 publications

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“…It is soluble in polar solvents and upon salvation, they swells, and in presence of a neutralizing agent forming a microgel system (GarciaGonzalez et al, 1994;Weber et al, 2012). These properties make them potential candidates for the use as transdermal gel formulations (Jana et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes

et al. 2014

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In order to develop transdermal drug delivery system that facilitates the skin permeation of Pioglitazone (PZ) encapsulated in carbopol-based transgel system (proniosomes/niosome). The developed formulations were optimized using quality by design (QbD) approach and particle size, percentage entrapment and transdermal flux were determined. It was found to be more efficient delivery carriers with high encapsulation and enhanced flux value demonstrated that the permeation of PZ through skin was significantly increased with developed formulation. The transdermal enhancement from proniosome was 3.16 times higher than that of PZ from control formulation (ethanol buffer formulation, 3:7), which was further confirmed by confocal laser scanning microscopy. In vivo pharmacokinetic study of carbopol transgel showed a significant increase in bioavailability (2.26 times) compared with tablet formulation. It also showed better antidiabetic activity in comparison to marketed tablet, so our results suggest that carbopol-based transgel are an efficient carrier for delivery of pioglitazone through skin.

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Section: Introductionmentioning

confidence: 99%

QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes

et al. 2014

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“…Topical gels are semisolid formulations, which have gained a greater deal of importance in the medical field for their topical effect in the treatment of pain, strain, inflammation, infections and other diseases [36][37][38][39][40] . In the current work, topical herbal gels containing aqueous extract of P. acerifolium seeds was developed using sodium carboxymethyl cellulose.…”

Section: Resultsmentioning

confidence: 99%

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2017

IJPSR

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ABSTRACT:The present work deals with formulation of topical gels containing aqueous extract of P. acerifolium seeds and also evaluation of prepared gels against some Gram-positive and Gram-negative bacteria. The antibacterial activity of various P. acerifolium seed extracts was measured through determining minimum inhibitory concentration (MIC) by cube dilution method and zone of inhibition by disc diffusion method against E. coli, P. aeruginosa and S. aureus. Aqueous P. acerifolium seed extracts exhibited comparatively higher antibacterial potential in comparison with that of other extracts and employed to formulate topical herbal gels using 4.5% sodium carboxymethyl cellulose as gel base. Prepared herbal gels were tested for pH, viscosity, extrudability and spreadability. All the prepared gels were subjected to antibacterial study by determining zone of inhibition by disc diffusion method. Herbal gels containing 15% aqueous P. acerifolium seed extract exhibited better zones of inhibition against E. coli, P. aeruginosa and S. aureus in comparison with that of 7.5% and 10%. From the results of this study, it can be concluded that herbal gels containing 15% aqueous P. acerifolium seed extract is found suitable for topical use against bacterial infections.

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“…The average zeta potential was determined using the instrument Malvern Nano ZS (Malvern Instruments, Zetasizer version 6.00, UK) following the particle electrophoretic light scattering principle. 33,34 Stability study. The GS gel was filled in an airtight container and incubated as per the ICH guideline at 2-8 1C (refrigeration condition) and 40 1C/65% RH (accelerated condition) for 3 months.…”

Section: Selection Of Penetration Enhancermentioning

confidence: 99%

Accentuated transdermal application of glucosamine sulphate attenuates experimental osteoarthritis induced by monosodium iodoacetate

et al. 2016

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Osteoarthritis is a chronic degenerative joint disease causing pain and disability. Glucosamine sulphate is a well known oral supplement for its treatment. The present pioneering study provides an overview of the accentuated transdermal delivery of glucosamine sulphate through the optimized gel formulation with guar gum and sodium carboxymethyl cellulose (Na-CMC). Response surface methodology based on the three-level three-factor central composite design provided the optimum concentration of guar gum, Na-CMC and glycerol for a maximum flux. The transdermal characterization, ex vivo permeation study and in vivo study were performed with optimized gel formulation. The factorial design predicted the optimum values of guar gum, Na-CMC and glycerol which were 418.53 mg, 444.97 mg and 2322.4 mg respectively for 25 g of the gel. This optimized gel demonstrated the maximum flux,i.e., 1047.46 mg cm À2 h À1 . The optimized gel showed satisfactory results with respect to drug uniformity, pH, stability, rheological properties, zeta potential, drug-excipient compatibility and skin irritation.The release of the drug from the optimized transdermal gel followed the controlled first order Fickian (non-steady) release pattern. The in vivo study was carried out in a rat model of osteoarthritis induced by monosodium iodoacetate damaging the tibial plateau. In this study the optimized formulation effectively reduced the symptoms like reduction in swelling of the knee joint, gross changes in digitized radio images and morphological and histopathological alterations. Additionally the changes in the release pattern of the proinflammatory cytokine tumor necrosis factor-a illustrated the efficacy of the transdermal gel for the treatment of experimental osteoarthritis. Thus the optimized gel was found to be a unique potential vehicle for transdermal application of glucosamine sulphate which effectively attenuates the experimental osteoarthritis.

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Carbopol gel containing chitosan-egg albumin nanoparticles for transdermal aceclofenac delivery

Cited by 201 publications

References 22 publications

QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes

QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes

Untitled

Accentuated transdermal application of glucosamine sulphate attenuates experimental osteoarthritis induced by monosodium iodoacetate

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