Carboplatin Niosomal Nanoplatform for Potentiated Chemotherapy

Alavi, Seyed Ebrahim; Raza, Aun; Esfahani, Maedeh Koohi Moftakhari; Akbarzadeh, Azim; Abdollahi, Seyed Hossein; Shahmabadi, Hasan Ebrahimi

doi:10.1016/j.xphs.2022.06.002

Cited by 14 publications

(5 citation statements)

References 63 publications

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“…For this purpose, 5 mL of each formulation equivalent to 36.9 and 29.6 mg of the nanoparticles for the PEGylated and non-PEGylated nanoparticles, respectively, were stored in a 4 °C refrigerator for 3 months, and their profiles of drug release, in vitro antitumor effects, size, PDI, and drug loading efficiency were measured using the methods mentioned above. In addition, the serum stability of PEG-Lip-CB, PEG-Lip-DOX, and PEG-Lip-DOX/CB, compared to Lip-DOX, Lip-CB, and Lip-DOX/CB, was measured in FBS [ 15 ]. For this purpose, a suspension of the formulations at a final concentration of 10 mg/mL was prepared in FBS:PBS (45:55% v/v ratio) and incubated for 5 h at 37 ℃.…”

Section: Methodsmentioning

confidence: 99%

“…PEG is a Food-and-Drug-Administration-approved polymer for human use that can improve the aqueous solubility of conjugates [ 11 , 12 , 13 ]. The PEGylation of liposomes could increase the blood circulation time of liposomes by providing steric stability, ensuring their higher tumor accumulation [ 14 , 15 ]. Doxorubicin (DOX) and carboplatin (CB) are two anticancer drugs used for the treatment of glioblastoma [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of PEGylated Liposomal Doxorubicin and Carboplatin Combination on Glioblastoma

et al. 2022

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Glioblastoma is an incurable cancer with a 5-year survival chance of less than 5%. Chemotherapy is a therapeutic approach to treating the disease; however, due to the presence of the blood–brain barrier (BBB), the probability of success is low. To overcome this issue, nanoparticles are promising carriers for crossing the BBB and delivering drugs to the tumor. In this study, the anticancer efficacy of doxorubicin (DOX) and carboplatin (CB) loaded into polyethylene glycol (PEG)ylated liposome nanoparticles (PEG-Lip) and in treating brain cancer was evaluated in vitro and in vivo. The results demonstrated that PEG-Lip-DOX/CB with a size of 212 ± 10 nm was synthesized that could release the loaded drugs in a controlled manner, from which 56.3% of the loaded drugs were released after 52 h. In addition, PEG-Lip-DOX/CB could significantly increase the cytotoxicity effects of the drugs against rat glioma C6 cells (IC50: 8.7 and 12.9 µM for the drugs-loaded nanoparticles and DOX + CB, respectively). The in vivo results also demonstrated that PEGylated liposomes, compared to non-PEGylated liposomes (Lip) and DOX + CB, were more efficient in increasing the therapeutic effects and decreasing the side effects of the drugs, in which the survival times of the glioblastoma-bearing rats were 39, 35, and 30 days in the PEG-Lip-DOX/CB, Lip-DOX/CB, and DOX + CB receiver groups, respectively. In addition, the weight loss was found to be 8.7, 10.5, and 13%, respectively, in the groups. The results of the toxicity evaluation were also confirmed by histopathological studies. Overall, the results of this study demonstrated that the encapsulation of DOX and CB into PEG-Lip is a promising approach to improving the properties of DOX and CB in terms of their therapeutic effects and drug side effects for the treatment of glioblastoma.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of PEGylated Liposomal Doxorubicin and Carboplatin Combination on Glioblastoma

et al. 2022

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“…The common preparation methods for liposomes include thin-film dispersion method, ultrasonic-dripping method, stirring-dropping method, and reverse-phase evaporation method (Alavi et al., 2022 ; Huang & Chen, 2023 ; Munot et al., 2023 ). The reverse-phase evaporation method is more suitable for loading water-soluble drugs, so the other three methods were selected to prepare ACGs-Lipo and the optimal preparation method for ACGs-Lipo was selected based on the average particle size and PDI of the liposomes.…”

Section: Resultsmentioning

confidence: 99%

Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2

Ao,

Song,

et al. 2024

Drug Delivery

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Annonaceous acetogenins (ACGs) have potent anti-tumor activity, and the problems of their low solubility, hemolysis, and in vivo delivery have been solved by encapsulation into nanoparticles. However, the high toxicity still limits their application in clinic. In this paper, the co-delivery strategy was tried to enhance the in vivo anti-tumor efficacy and reduce the toxic effects of ACGs. Ginsenoside Rh2, a naturally derived biologically active compound, which was reported to have synergistic effect with paclitaxel, was selected to co-deliver with ACGs. And due to its similarity with cholesterol in chemical structure, the co-loading liposomes, (ACGs + Rh2)-Lipo, were successfully constructed using Rh2 instead of cholesterol as the membrane material. The obtained (ACGs + Rh2)-Lipo and ACGs-Lipo had similar mean particle size (about 80 nm), similar encapsulation efficiency (EE, about 97%) and good stability. The MTS assay indicated that (ACGs + Rh2)-Lipo had stronger toxicity in vitro . In the in vivo study, in contrast to ACGs-Lipo, (ACGs + Rh2)-Lipo demonstrated an improved tumor targetability (3.3-fold in relative tumor targeting index) and significantly enhanced the antitumor efficacy (tumor inhibition rate, 72.9 ± 5.4% vs. 60.5 ± 5.4%, p < .05). The body weight change, liver index, and spleen index of tumor-bearing mice showed that Rh2 can attenuate the side effects of ACGs themselves. In conclusion, (ACGs + Rh2)-Lipo not only alleviated the toxicity of ACGs to the organism, but also enhanced their anti-tumor activity, which is expected to break through their bottleneck.

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“…Nanomedicine has exerted a considerable influence on diverse DDSs, encompassing controlled-release wound dressings and biocompatible nano carriers tailored for biomedical applications . Delivery systems are able to enhance the therapeutic effects of compounds. − In the context of different types of skin wounds, such as acute, chronic, and burn wounds, rapid healing is crucial due to the skin’s vital role in protecting underlying cells and tissues . Despite the availability of numerous wound dressings and medical devices, the healing process primarily involves wound repair rather than complete regeneration, resulting in a considerable amount of time dedicated to this phase .…”

Section: Drug Delivery Systems For Wound Healing and Skin Regenerationmentioning

confidence: 99%

Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery Innovations

Alavi,

Nisa

et al. 2024

Mol. Pharmaceutics

Self Cite

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Human skin is the largest organ and outermost surface of the human body, and due to the continuous exposure to various challenges, it is prone to develop injuries, customarily known as wounds. Although various tissue engineering strategies and bioactive wound matrices have been employed to speed up wound healing, scarring remains a significant challenge. The wound environment is harsh due to the presence of degradative enzymes and elevated pH levels, and the physiological processes involved in tissue regeneration operate on distinct time scales. Therefore, there is a need for effective drug delivery systems (DDSs) to address these issues. The objective of this review is to provide a comprehensive exposition of the mechanisms underlying the skin healing process, the factors and materials used in engineering DDSs, and the different DDSs used in wound care. Furthermore, this investigation will delve into the examination of emergent technologies and potential avenues for enhancing the efficacy of wound care devices.

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Carboplatin Niosomal Nanoplatform for Potentiated Chemotherapy

Cited by 14 publications

References 63 publications

Impact of PEGylated Liposomal Doxorubicin and Carboplatin Combination on Glioblastoma

Impact of PEGylated Liposomal Doxorubicin and Carboplatin Combination on Glioblastoma

Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2

Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery Innovations

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