“…We selected trifluoroacetimidoyl chloride 1a with n -butyl amine 2b as a model substrate to initiate the reaction (Table 1). The reaction was performed in the presence of the Pd/AFCs (1 mol%), PPh 3 (5 mol%) and K 2 CO 3 (2.0 equiv) in 1,4-dioxane at 100 °C for 12 h with benzene-1,3,5-triyl triformate (TFBen) as a convenient CO surrogate, 55–57 and to our delight, the desired 2-trifluoromethyl-quinazolin-4(3 H )-one product 3b was obtained in 76% yield (Table 1, entry 1). Prompted by the positive result, we next screened a series of organic solvents, which indicated that various commonly used solvents could serve as the reaction medium but the efficiency was inferior to that of 1,4-dioxane (Table 1, entries 2–6).…”