Carbonyl stress in diabetics with acute coronary syndrome

Bora, Sushmita; Adole, Prashant Shankarrao

doi:10.1016/j.cca.2021.06.002

Cited by 13 publications

(6 citation statements)

References 115 publications

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“…Most of the effects of carbonyl compounds are executed by AGEs, which bind to and alter the tertiary structure and function of proteins. Several studies have reported the positive association between plasma carbonyl compounds and AGEs levels in DM patients ( 52 ). While MGO has been associated with oxidative and inflammatory responses through the formation of AGEs ( 52 ), here we showed that MGO decreases the expression of HIF-1-regulated immunometabolic molecules and impairs the control of M. tuberculosis during infection of IFN-γ activated and control BMM.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported the positive association between plasma carbonyl compounds and AGEs levels in DM patients ( 52 ). While MGO has been associated with oxidative and inflammatory responses through the formation of AGEs ( 52 ), here we showed that MGO decreases the expression of HIF-1-regulated immunometabolic molecules and impairs the control of M. tuberculosis during infection of IFN-γ activated and control BMM. Of interest, MGO did not decrease the levels of HIF-1α in BMM before or after infection with M. tuberculosis but might have inhibited the expression of HIF-1α-regulated genes by a ROS-mediated modification of p300 ( 31 , 48 , 53 , 54 ).…”

Section: Discussionmentioning

confidence: 99%

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High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages

Terán

Catrina

et al. 2022

mBio

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages

Terán

Catrina

et al. 2022

mBio

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“…It is widely acknowledged that organ damage due to carbonyl (electrophilic) stress plays a crucial role in the pathogenesis of numerous pathological conditions (Angeloni et al., 2014; Bora & Shankarrao Adole, 2021; Tezuka et al., 2019). Carbonyl stress has been identified as a driving force in glycation and AGEs formation (Saeed et al., 2020).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and antiglycation activity of 3‐phenacyl substituted thiazolium salts, new analogs of Alagebrium

Ozerov,

Merezhkina,

Zubkov

et al. 2023

Chem Biol Drug Des

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After preliminary ab initio calculations, 3‐phenacyl substituted thiazolium salts, analogs of Alagebrium, were synthesized and investigated in vitro as glycation reaction inhibitors. The most part of investigations focused on the potential of the title compounds to attenuate the formation of fluorescent AGEs as well on their ability to disrupt the cross‐linking formation among glycated proteins. Additionally, the capability of thiazolium salts to deglycate in the reaction of early glycation products with nitroblue tetrazolium was determined. Cytotoxicological properties of the title compounds were evaluated using LDH and MTT assays. The leader compound (3‐[2‐(biphenyl‐4‐yl)‐2‐oxoethyl]‐1,3‐thiazol‐3‐ium bromide) in a 50 mg/kg dose (p.o. 14 days) was further tested within an in vivo carbonyl stress model (rats, methylglyoxal 86.25 mg/kg/d, i.p., 14 days). As a result, the leader‐molecule revealed a high effectiveness against all three examined mechanisms of glycation reaction inhibition in in vitro tests and was able to suppress capacity of methylglyoxal to form AGEs in vivo.

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“…Поширеність та частота розвитку ЦД зростають у всьому світі, що призводить до значно вищого рівня ускладнень ІХС [2].…”

Section: вступunclassified

Asymmetric dimethylarginine – a marker of repeated cardiovascular events in patients with comorbid pathology

Feldman¹

2021

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Today, diseases of the cardiovascular system retain their leading position among the incidence in the world. The presence of comorbid pathology in the form of type 2 diabetes mellitus (DM) significantly complicates the course of these diseases, worsening its prognosis. The aim of the study: to analyze the prognostic value of asymmetric dimethylarginine (ADMA) as a marker of recurrent cardiovascular events in patients with acute myocardial infarction with type 2 diabetes for 6 months of follow-up. 120 patients were examined: group 1 – patients with acute myocardial infarction (AMI) in combination with type 2 diabetes mellitus (n=70), group 2 - patients with isolated AMI (n=50). The control group included 20 practically healthy individuals. All patients underwent general clinical and instrumental examinations, on the first day of AMI the level of ADMA was determined using a commercial test system "Human Asymmetrical Dimethylarginine ELISA". Statistical processing of the obtained data was performed using the software package StatSoft Inc, USA – "Statistica 6.0". The analysis of the average level of ADMA showed a significantly higher value of this indicator in patients with AMI in combination with type 2 DM than in patients without concomitant type 2 DM 2.57 times (1.57±0.11 μmol / l and 0.61±0.06 μmol / l, respectively), (p<0,05. ADMA level >1,72 μmol / l in patients with AMI in combination with type 2 DM and >0,69 μmol / l in patients with AMI without concomitant type 2 DM was identified as a predictor of recurrent acute myocardial infarction within 6 months of follow-up. Thus, the level of ADMA was higher in the presence of comorbid pathology in the form of type 2 DM in patients with AMI, reflecting endothelial dysfunction combining disease. It is advisable to further study this indicator of endothelial dysfunction as a predictor of the adverse course of AMI in combination with concomitant type 2 DM.

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Carbonyl stress in diabetics with acute coronary syndrome

Cited by 13 publications

References 115 publications

High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages

High Glucose and Carbonyl Stress Impair HIF-1-Regulated Responses and the Control of Mycobacterium tuberculosis in Macrophages

Synthesis and antiglycation activity of 3‐phenacyl substituted thiazolium salts, new analogs of Alagebrium

Asymmetric dimethylarginine – a marker of repeated cardiovascular events in patients with comorbid pathology

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