Carbonyl Compounds Containing Formaldehyde Produced from the Heated Mouthpiece of Tobacco Sticks for Heated Tobacco Products

Abstract

Diverse harmful compounds can be emitted during the heating of tobacco sticks for heated tobacco products (HTPs). In this study, the generation of harmful compounds from the filter, instead of tobacco in tobacco sticks, was confirmed. The heat of a heated tobacco product device can be transferred to the tobacco stick filter, resulting in the generation of harmful compounds from the heated filter. Since the heating materials (tobacco consumable) of the tobacco sticks evaluated in this study were different depending on the brand, the harmful compounds emitted from the heated tobacco stick filters were examined by focusing on the carbonyl compounds, using three different tobacco stick parts. Acetaldehyde and propionaldehyde exhibited the highest concentrations in HTP aerosols produced by heating the tobacco consumable (conventional case) (63.5 ± 18.4 µg/stick and 1.71 ± 0.123 µg/stick, respectively). The aerosols produced by heating tobacco stick filters had higher formaldehyde and acrolein concentrations (0.945 ± 0.214 µg/stick and 0.519 ± 0.379 µg/stick) than the aerosols generated from heated tobacco consumable (0.641 ± 0.092 µg/stick and 0.220 ± 0.102 µg/stick). As such, formaldehyde and acrolein were produced by heating small parts of the mouthpiece of a tobacco stick, regardless of the heated tobacco product brand. In addition, acetone was only detected in the aerosols generated from heated filters (0.580 ± 0.305 µg/stick). Thus, safety evaluations of heated tobacco products should include considerations of the harmful compounds generated by heating tobacco stick mouthpieces for heated tobacco products in addition to those found in heated tobacco product aerosols.

Measuring the quantity of harmful volatile organic compounds inhaled through masks

“…The aldehydes (formaldehyde (FA), acetaldehyde (AA), and propionaldehyde (PA)), which were difficult to quantify with the ST/TD-GC-MS system, were quantitatively analyzed using the DNPH cartridge-HPLC-UV system ( Dutta et al, 2018 , Kim and Kim, 2016 ). Elution of the three aldehydes from the DNPH cartridge was induced by injecting 5 mL of acetonitrile into the DNPH cartridge where aldehyde was collected, and the eluted aldehydes were loaded into the HPLC-UV system, followed by separation and quantitative analysis ( Kim et al, 2020 ). Detailed information concerning our instrumental system is also provided in Table 3 .…”