Carbonized human hair derived carbon dots for detection of clozapine

Tao, Yongqing; Wan, Runlan; Wang, Junji; Liu, Qiuyi; Tian, Meng; Wang, Luchun; Yang, Yunfeng; Zou, Yuemeng; Luo, Yuanning; Ke, Famin; Zhou, Quan; Wang, Dandan; Gao, Die

doi:10.1016/j.saa.2023.122803

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…The micrograph in high-resolution TEM verified a graphite-like crystalline structure with a lattice spacing of 0.241 nm (Figure 1D), congruent with the common lattice spacing of carbon skeletons in CDs derived from other natural products (Zhai et al, 2023). In accordance with the recombination of radiation on the surface functional groups, numerous CDs possess distinctive optical characteristics and luminescence (Liu et al, 2022;Tao et al, 2023). Spectral analyses of AFI-CDs revealed weak π-π* electronic Frontiers in Molecular Biosciences frontiersin.org transitions in the sp 2 domains at approximately 280 nm in the UVvis spectrum (Lu et al, 2021), and their maximal emission and excitation were observed at 320 nm and 440 nm, respectively, in fluorescence spectra (Figure 1F).…”

Section: Synthesis and Characterization Of Afi-cdssupporting

confidence: 71%

Natural biomass-derived carbon dots as a potent solubilizer with high biocompatibility and enhanced antioxidant activity

Wu,

Li,

et al. 2023

Front. Mol. Biosci.

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Numerous natural compounds exhibit low bioavailability due to suboptimal water solubility. The solubilization methods of the modern pharmaceutical industry in contemporary pharmaceutical research are restricted by low efficiency, sophisticated technological requirements, and latent adverse effects. There is a pressing need to elucidate and implement a novel solubilizer to ameliorate these challenges. This study identified natural biomass-derived carbon dots as a promising candidate. We report on natural fluorescent carbon dots derived from Aurantia Fructus Immatures (AFI-CDs), which have exhibited a remarkable solubilization effect, augmenting naringin (NA) solubility by a factor of 216.72. Subsequent analyses suggest that the solubilization mechanism is potentially contingent upon the oration of a nanostructured complex (NA-AFI-CDs) between AFI-CDs and NA, mediated by intermolecular non-covalent bonds. Concomitantly, the synthesized NA-AFI-CDs demonstrated high biocompatibility, exceptional stability, and dispersion. In addition, NA-AFI-CDs manifested superior free radical scavenging capacity. This research contributes foundational insights into the solubilization mechanism of naringin-utilizing AFI-CDs and proffers a novel strategy that circumvents the challenges associated with the low aqueous solubility of water-insoluble drugs in the field of modern pharmaceutical science.

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