Carbonic Anhydrase VI Gene Polymorphism rs2274327 Relationship Between Salivary Parameters and Dental-Oral Health Status in Children

Şengül, Fatih; Kiliç, Münevver; Gürbüz, Taşkın; Taşdemir, Şener

doi:10.1007/s10528-016-9733-1

Cited by 10 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the physiological role of CA VI has not been established, it may be required for oral homeostasis to regulate against acidic environments [ 170 ]. Maintenance of proper pH levels in the saliva protects against enamel erosion and acid neutralization in biofilms and prevents dental caries [ 171 , 178 , 179 , 180 ]. Inhibition of CA VI was shown to cause taste perversion and sometimes complete loss of taste [ 173 , 181 ].…”

Section: Secreted Ca Isoforms: Expression Distribution and Functmentioning

confidence: 99%

Carbonic Anhydrases: Role in pH Control and Cancer

et al. 2018

View full text Add to dashboard Cite

The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new therapeutic targets. This includes an understanding of the role pH plays in primary tumor cells, and the regulatory factors that permit cancer cells to thrive. Over the last decade, carbonic anhydrases (CAs) have been shown to be important mediators of tumor cell pH by modulating the bicarbonate and proton concentrations for cell survival and proliferation. This has prompted an effort to inhibit specific CA isoforms, as an anti-cancer therapeutic strategy. Of the 12 active CA isoforms, two, CA IX and XII, have been considered anti-cancer targets. However, other CA isoforms also show similar activity and tissue distribution in cancers and have not been considered as therapeutic targets for cancer treatment. In this review, we consider all the CA isoforms and their possible role in tumors and their potential as targets for cancer therapy.

show abstract

Section: Secreted Ca Isoforms: Expression Distribution and Functmentioning

confidence: 99%

Carbonic Anhydrases: Role in pH Control and Cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Individuals with a variant G allele showed differential fungiform papillae density and morphology, and the variant G allele modified the intensity of bitterness both on its own and in concert with the TAS2R38 haplotype [16]. The variant CAVI protein also showed an association with the risk of caries and other oral health parameters [21, 22]. Moreover, some CA isozymes are thought to be associated with unregulated cell proliferation and malignancy invasion [23, 24].…”

Section: Introductionmentioning

confidence: 99%

Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans

Choi

Lee

et al. 2017

Oncotarget

View full text Add to dashboard Cite

Bitterness perception is known to be an important factor in individuals' dietary behaviors and is also associated with the sensing of nutritious/noxious molecules for subsequent metabolic responses in multiple organs. Therefore, the genetic variation in bitterness sensing may be associated with diet-related diseases, including colorectal cancer (CRC). We investigated the influence of variations in the bitterness-sensing genes taste receptor type 2 member 38 (TAS2R38) and carbonic anhydrase 6 (CA6) on the consumption of food, tobacco and alcohol and the risk of CRC in Koreans. The study population consisted of 681 cases and 1361 controls, and their intake of vegetables, fruits, fiber, fat-food and sweets was analyzed. The genotypes for TAS2R38 A49P, V262A and I296V and CA6 rs2274333 A/G were assessed using the MassArray technique. Our findings suggested that the TAS2R38 diplotype, CA6 rs2274333 and their combined genotype had a negligible influence on dietary and alcohol intake. The combined TAS2R38-CA6 AVI/AVI-AA genotype was associated with higher tobacco consumption than the other genotypes in CRC cases only. However, the genetic variations were a significant risk factor for CRC. The TAS2R38 AVI/AVI diplotype and CA6 G allele were associated with a reduced risk of CRC. Moreover, when the combined genotypes of the subjects were analyzed, possessing both the variant diplotype/variant allele (AVI/AVI+G*) was associated with a greater reduction in the risk of CRC (adjusted OR = 0.49; 95%CI: 0.34-0.74). In summary, variations in the bitterness perception genes TAS2R38 and CA6 did not influence the examined food intake in Koreans. However, those genetic variants were a decisive modifying factor of CRC susceptibility.

show abstract

“…Accordingly, several studies in humans have indicated that polymorphisms in genes involved in enamel formation [Patir et al, 2008;Kang et al, 2011;Shimizu et al, 2012;Tannure et al, 2012;Saha et al, 2015], saliva composition [Anjomshoaa et al, 2015;Sengul et al, 2016], and immune response [Bagherian et al, 2008;Azevedo et al, 2010;Valarini et al, 2012;Fine et al, 2013], including DEFB1 [Ozturk et al, 2010;Krasone et al, 2014;Yildiz et al, 2016], play a role in caries susceptibility.…”

mentioning

confidence: 99%

Genetic Polymorphisms in DEFB1 and miRNA202 Are Involved in Salivary Human β-Defensin 1 Levels and Caries Experience in Children

Lips

Antunes²,

Antunes³

et al. 2017

Caries Res

View full text Add to dashboard Cite

The antimicrobial peptides human β-defensins (hBDs) are encoded by β-defensin genes (DEFBs) and are possibly involved in caries susceptibility. In this study we aimed (1) to investigate the relationship between salivary hBDs and caries and (2) to evaluate the association of genetic polymorphisms in DEFB1 and microRNA202 (miRNA202) with salivary levels of hBDs and caries experience. Two data sets were available for this study, totalizing 678 Brazilian children. Dental examination and saliva collection were performed in all included children. The salivary level for hDB1, hBD2, and hBD4 was assessed by ELISA sandwich technique in 168 children. The DNA was extracted from saliva, and polymorphisms in DEFB1 and miRNA202 were analyzed by real-time PCR. Statistical analysis was performed to investigate the associations between caries experience, hBD salivary level, genotype, and allele distribution, with an alpha of 0.05. The hBD1 level was significantly higher in caries-free children (p < 0.0001). The miRNA202 was associated with a lower level of salivary hBD1 (p < 0.05). Also, the polymorphic distribution of miRNA202 was associated with caries (p = 0.006). The polymorphisms in DEFB1 were not associated with hBD salivary level and caries experience (p > 0.05). In conclusion, our results indicate that genetic polymorphism in miRNA202 is involved in hBD1 salivary level as well as caries experience in children.

show abstract

Carbonic Anhydrase VI Gene Polymorphism rs2274327 Relationship Between Salivary Parameters and Dental-Oral Health Status in Children

Cited by 10 publications

References 20 publications

Carbonic Anhydrases: Role in pH Control and Cancer

Carbonic Anhydrases: Role in pH Control and Cancer

Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans

Genetic Polymorphisms in DEFB1 and miRNA202 Are Involved in Salivary Human β-Defensin 1 Levels and Caries Experience in Children

Contact Info

Product

Resources

About