Carbonic Anhydrase IX Expression and Outcome after Radiotherapy for Muscle-invasive Bladder Cancer

Sherwood, B.T.; Colquhoun, Alexandra; Richardson, Donna; Bowman, Karen J.; O’Byrne, Kenneth J.; Kockelbergh, Roger; Symonds, R. Paul; Mellon, J. Kilian; Jones, George D.D.

doi:10.1016/j.clon.2007.06.014

Cited by 15 publications

(12 citation statements)

References 25 publications

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“…Carbonic anhydrase IX was demonstrated in urothelial carcinoma of the bladder, renal pelvis and ureter. Our result of 78% positivity for high‐grade urothelial carcinoma is consistent with published data, ranging from 71 to 90% 22–24 . Klatte et al.…”

Section: Discussionsupporting

confidence: 93%

Expression of carbonic anhydrase IX in genitourinary and adrenal tumours

Donato¹,

Johnson

Yang

et al. 2011

Histopathology

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Carbonic anhydrase IX is a sensitive marker for clear cell RCC in core biopsies. However, other genitourinary or adrenal tumours that can have a clear cell appearance including urothelial, squamous cell, clear cell adeno and adrenal cortical carcinoma and Sertoli cell tumour express CAIX. Knowledge of expression overlap between these entities may prevent incorrect interpretation of immunohistochemical results, particularly if limited tissue is available.

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Section: Discussionsupporting

confidence: 93%

Expression of carbonic anhydrase IX in genitourinary and adrenal tumours

Donato¹,

Johnson

Yang

et al. 2011

Histopathology

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“…Nuclear localization has also been noted in a variable proportion of adult-epithelial type tumors and lymphomas [23][24][25]. Patients with bladder cancers that showed CA IX nuclear staining were more likely to experience a rapid local recurrence after a positive response to radiotherapy than patients with no tumoral nuclear expression [24].…”

Section: Discussionmentioning

confidence: 97%

Carbonic anhydrase IX up-regulation is associated with adverse clinicopathologic and biologic factors in neuroblastomas

2012

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“…Wykoff et.al has observed CA is hypoxia-inducible factor-1 (HIF-1)-dependent [25]. HIF-1, recognized as a key mediator of gene expression in hypoxic tumors [26], is another transcription factor in nickel-transformed cells [27]. Therefore, CA3 probably acts as a key gene in nickel- The genes are considered true positives, i.e.…”

Section: Discussionmentioning

confidence: 99%

Identification of Differentially Expressed Genes in Lung Tissues of Nickel-Exposed Rats Using Suppression Subtractive Hybridization

Zhang

Fan

et al. 2010

Biol Trace Elem Res

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Occupational exposure to nickel compound, such as nickel refining, electroplating, and in conjunction with other metals, is harmful to the health, causing respiratory distress, and lung and nasal cancer. In this work, the different gene expression patterns of lung tissues from nickel-exposed rats and controls were investigated. The suppression subtractive hybridization (SSH) method was used to generate two subtracted cDNA libraries with gene transcripts differentially expressed after nickel inducing. Dot-blot hybridizations were used to confirm differential ratios of expression of obtained SSH clones. Out of 768 unique SSH clones, which were chosen randomly from the two subtraction libraries (384 of each), 319 could be verified as differentially expressed. According to blast screening and functional annotation, 28% genes in nickel-induced cDNA library were related to cell differentiation, whereas 21% in driver library were related to oxygen transport. Two novel expressed sequence tags (ESTs; NCBI Accession No. FC809414 and No. FC809411) in nickel-induced cDNA library were obtained. The genes detected in the present study are probably important genes associated with nickel-induced lung cancer.

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Carbonic Anhydrase IX Expression and Outcome after Radiotherapy for Muscle-invasive Bladder Cancer

Cited by 15 publications

References 25 publications

Expression of carbonic anhydrase IX in genitourinary and adrenal tumours

Expression of carbonic anhydrase IX in genitourinary and adrenal tumours

Carbonic anhydrase IX up-regulation is associated with adverse clinicopathologic and biologic factors in neuroblastomas

Identification of Differentially Expressed Genes in Lung Tissues of Nickel-Exposed Rats Using Suppression Subtractive Hybridization

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