Carbonic anhydrase inhibitors: an editorial

Cloning, expression and biochemical characterization of aβ-carbonic anhydrase from the soil bacteriumEnterobactersp. B13

“…In fact there are two types of b-CAs in organisms all over the phylogenetic tree, which are defined by their pH-catalytic activity profile as well as active site structural configuration [41][42][43][44][45][46][47][48][49][50][51][52] . Type I b-CAs display catalytic activity over a broad pH range (6.5-9.0) with the active site zinc tetrahedrally coordinated by three amino acid residues (two Cys and one His) and a hydroxide/water.…”

A new procedure for the cloning, expression and purification of the β-carbonic anhydrase from the pathogenic yeastMalassezia globosa, an anti-dandruff drug target

“…HCO À 3 + H + is slow at physiological pH and thus, in biological systems, the reaction is accelerated by enzymatic catalysts, called carbonic anhydrases (CAs, EC 4.2.1.1). The conversion of CO 2 to bicarbonate and protons is a physiologically relevant reaction in all life kingdoms 8,10,14,[16][17][18] .…”

Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives

“…hCA I considered as a potential drug target treatment of pathogenesis of proliferative diabetic retinopathy and diabetic macular edema, as it mediates hemorrhagic retinal and cerebral vascular permeability through activation of prekallikrein and generation of the highly active serine protease factor XIIa 8 12,29 . Considering these phenomena even these new N-protected amino acid-benzothiazole conjugates which do not possess very strong affinity to hCA I but show selectivity toward this isoform, might be considered as interesting starting molecules for developing hCA I selective scaffolds with biomedical applications [30][31][32][33][34][35] .…”