Carbonfluorine bond activation by platinum group metal complexes

Ruthenium Olefin Metathesis Catalysts Containing Fluoride

“…1 Organofluorine compounds are nowadays employed in the agrochemical and pharmaceutical industry, with an ever increasing demand for this class of compounds. 2 Fluorine has been introduced into metal-complexes as fluoride ligand.…”

“…2,4 As a result, only a limited number of examples of transition metal fluoride complexes (namely Pd, 5a Pt, 5b Ir, 5c Os 5d-f and Ru 5e-k ) has been disclosed to date. Most synthetic protocols leading to M-F bond formation involve an oxidative addition of XeF 2 in anhydrous HF or reaction with Et 3 N·3HF.…”

Palladium-Mediated Organofluorine Chemistry

“…169 Under the conditions of the Stille cross-coupling, this circumstance produces in solution a mixture of isomers cis-and trans-[PdR F IL 2 ] that can undergo the transmetalation reaction competitively. 104 The reaction has been studied for the cross coupling of C 6 Hence, in this system the amount of palladium that is able to participate in the catalysis decreases steadily during the reaction course. …”

“…So, the selective cleavage of one or several C-F bonds in those molecules followed by a suitable functionalization is a way to obtain partially fluorinated compounds of high interest. Reviews with an extensive coverage of the subjects of C-F activation, 6,7,[224][225][226] and fluorination 10,227,228 are available in the literature. The purpose of this section is to cover palladium mediated processes in the area.…”

“…A non-comprehensive list of recent reviews is given in references 3-19. 1,[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Some of the challenges for the preparation of organofluorine derivatives lay on the development of suitable fluorine reagents that are not too reactive, as fluorine itself, or too unreactive because in order to give the desired reaction there is the need of the cleavage of a strong E-F bond. Some of the well developed and useful catalytic reactions for non-fluorinated compounds have been applied to the synthesis of fluoroderivatives but, in many cases, the reactions are not as effective as expected or simply do not work.…”