Carbonation of Epoxidized Methyl Soyates in Tetrabutylammonium Bromide-Based Deep Eutectic Solvents

Liu, Wei; Lu, Guoyan

doi:10.5650/jos.ess17194

Cited by 11 publications

(7 citation statements)

References 40 publications

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“…However, this is by no means the complete picture. Many other groups have designed and tested STS inhibitors [ 6 , 114 , 115 , 116 , 117 ] and will not be reviewed here.…”

Section: The Further Development Of Sts Inhibitorsmentioning

confidence: 99%

Steroid Sulphatase and Its Inhibitors: Past, Present, and Future

Foster

2021

Molecules

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Steroid sulphatase (STS), involved in the hydrolysis of steroid sulphates, plays an important role in the formation of both active oestrogens and androgens. Since these steroids significantly impact the proliferation of both oestrogen- and androgen-dependent cancers, many research groups over the past 30 years have designed and developed STS inhibitors. One of the main contributors to this field has been Prof. Barry Potter, previously at the University of Bath and now at the University of Oxford. Upon Prof. Potter’s imminent retirement, this review takes a look back at the work on STS inhibitors and their contribution to our understanding of sulphate biology and as potential therapeutic agents in hormone-dependent disease. A number of potent STS inhibitors have now been developed, one of which, Irosustat (STX64, 667Coumate, BN83495), remains the only one to have completed phase I/II clinical trials against numerous indications (breast, prostate, endometrial). These studies have provided new insights into the origins of androgens and oestrogens in women and men. In addition to the therapeutic role of STS inhibition in breast and prostate cancer, there is now good evidence to suggest they may also provide benefits in patients with colorectal and ovarian cancer, and in treating endometriosis. To explore the potential of STS inhibitors further, a number of second- and third-generation inhibitors have been developed, together with single molecules that possess aromatase–STS inhibitory properties. The further development of potent STS inhibitors will allow their potential therapeutic value to be explored in a variety of hormone-dependent cancers and possibly other non-oncological conditions.

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“…However, this is by no means the complete picture. Many other groups have designed and tested STS inhibitors [ 6 , 114 , 115 , 116 , 117 ] and will not be reviewed here.…”

Section: The Further Development Of Sts Inhibitorsmentioning

confidence: 99%

Steroid Sulphatase and Its Inhibitors: Past, Present, and Future

Foster

2021

Molecules

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“…The signals intensity from the protons of epoxy ring appeared at δ = 2.80─3.20 ppm were diminished after the synthesis of Bio-oil 2 and new peaks due to the protons of cyclic carbonated group emerged in the range of δ = 4.4─4.7 ppm which is in accordance with the reported literature. 28,29,30 Ethyl acetate peak came from the cleaning step which was performed to remove the catalyst. 13 C-NMR (100 MHz, CDCl 3 ) of Bio-oil 2 also confirmed the occurrence of carbonated five-membered cyclic group due to the appearance of new peak at 155 ppm as represented in the supporting information (Figure S1).…”

Section: Characterization Of Carbonated Biooilmentioning

confidence: 99%

Synthetical modification of plant oil‐based plasticizer with CO₂ leads to reduced migration from NBR rubber

Shahzad

Rahman

Wittchen

et al. 2021

J of Applied Polymer Sci

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The increasing environmental and toxic health concerns due to phthalate-based plasticizers are pushing researchers to eliminate these market leader plasticizers and to find nature-friendly bio-based plasticizers with reduced migration. The present study is also an effort in this regard. Herein, the epoxidized monoester of glycerol formal based on soybean oil is synthetically modified by carbonation in the presence of a catalyst to increase the polarity of the plasticizer. These modified and pristine plasticizers were incorporated in acrylonitrile─butadiene rubber and their migration analysis during heating the sample for 60 h were performed using fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR) by observing the absorbance of the characteristic carbonyl stretching vibration peak (1736 cm À1 ) of plasticizer relative to the C H stretching vibration of butadiene (968 cm À1 ). The results of migration kinetics and mechanical testing demonstrated reduction of diffusion coefficients by modification while hardness and tensile strength are hardly affected. In addition to the fact that soybean oil as a natural resource is more sustainable, the additional synthesis step of binding CO 2 is advantageous for a green chemistry approach.

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“…To increase the solubility of the catalysts, the utilization of large amount organic solvents cannot be avoided in this procedure. [3] Several types of homogeneous and heterogeneous catalysts which are quite not environmentally friendly, are used in the existing methods to produce CCs through the cycloaddition reaction of CO 2 . For example, quaternary ammonium salts, [4] ionic liquids, [5] alkali metal salts, [6] metal oxides, [7] titanosilicates, [8] polyoxometalates (POM), [9] and zeolites.…”

Section: Introductionmentioning

confidence: 99%

Solvent‐Free CO₂ Fixation Reaction Catalyzed by MOFs Composites Containing Polycarboxylic Acid Ligands

et al. 2021

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Metal-Organic Frameworks (MOFs) have been used to catalyze the conversion of CO 2 to cyclic carbonates through cycloaddition reaction. A series of MOFs composites based on Cu-BTC (H 3 BTC, 1,3,5-Benzenetricarboxylic acid) were screened out by adjusting the ligands and loaded materials. Among them, Cu-BTC@ZnFe 2 O 4 achieved good yields in this reaction, and after several catalytic cycles, the yield also remained above 90 %. The larger the steric hindrance of epoxides used, the lower the yields of cycloaddition reaction. In addition, computational chemistry was used to explain this catalytic process. After adding the catalyst, the energy barrier of the initial step of the reaction was effectively reduced.

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Carbonation of Epoxidized Methyl Soyates in Tetrabutylammonium Bromide-Based Deep Eutectic Solvents

Cited by 11 publications

References 40 publications

Steroid Sulphatase and Its Inhibitors: Past, Present, and Future

Steroid Sulphatase and Its Inhibitors: Past, Present, and Future

Synthetical modification of plant oil‐based plasticizer with CO₂ leads to reduced migration from NBR rubber

Solvent‐Free CO₂ Fixation Reaction Catalyzed by MOFs Composites Containing Polycarboxylic Acid Ligands

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Carbonation of Epoxidized Methyl Soyates in Tetrabutylammonium Bromide-Based Deep Eutectic Solvents

Cited by 11 publications

References 40 publications

Steroid Sulphatase and Its Inhibitors: Past, Present, and Future

Steroid Sulphatase and Its Inhibitors: Past, Present, and Future

Synthetical modification of plant oil‐based plasticizer with CO2 leads to reduced migration from NBR rubber

Solvent‐Free CO2 Fixation Reaction Catalyzed by MOFs Composites Containing Polycarboxylic Acid Ligands

Contact Info

Product

Resources

About

Synthetical modification of plant oil‐based plasticizer with CO₂ leads to reduced migration from NBR rubber

Solvent‐Free CO₂ Fixation Reaction Catalyzed by MOFs Composites Containing Polycarboxylic Acid Ligands