Carbonate content control in carbonate apatite coatings of biodegradable magnesium

Midorikawa, Kazuma; Hiromoto, Sachiko; Yamamoto, Tomoyuki

doi:10.1016/j.ceramint.2023.12.021

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…Firstly, it is important to note that the mineralization of carbonate apatite in the PLA and PLA:OLA samples is in good agreement with the Ca/P ratio previously described. The XRD patterns of HA and carbonated apatite are very similar; however, in carbonate apatite, the crystallographic peaks at 2θ = 26°, attributed to the [002] crystallographic plane of the hexagonal structure of HA, shifts to a lower value of 2θ = 25.5° [ 41 ]. In our PLA and PLA:OLA electrospun fibers, this crystallographic peak showed a higher intensity in comparison with those obtained for the electrospun fibers reinforced with both MgO and Mg(OH) 2 .…”

Section: Resultsmentioning

confidence: 99%

Bioactivity and Antibacterial Analysis of Plasticized PLA Electrospun Fibers Reinforced with MgO and Mg(OH)2 Nanoparticles

Leonés,

Salaris,

Peponi

et al. 2024

Polymers

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In this work, we focused on the bioactivity and antibacterial behavior of PLA-based electrospun fibers, efibers, reinforced with both MgO and Mg(OH)2 nanoparticles, NPs. The evolution of PLA-based efibers was followed in terms of morphology, FTIR, XRD, and visual appearance. The bioactivity was discussed in terms of hydroxyapatite growth after 28 days, considered as T28, of immersion in simulated body fluid, SBF. In particular, the biomineralization process evidenced after immersion in SBF started at T14 in both systems. The number of precipitated crystals increased by increasing the amount of both NPs. The chemical composition of the precipitated crystals was also characterized in terms of the Ca/P molar ratio after T28 of immersion in SBF, indicating the presence of hydroxyapatite on the surface of both reinforced efibers. Moreover, a reduction in the average diameter of the PLA-based efibers was observed, reaching a maximum reduction of 46 and 60% in the average diameter of neat PLA and PLA:OLA efibers, respectively, after 28 days of immersion in SBF. The antibacterial behavior of the MgO and Mg(OH)2 NPs in the PLA-based electrospun fibers was tested against Escherichia coli, E. coli, as the Gram-negative bacteria, and Staphylococcus aureus, S. aureus, as the Gram-positive bacteria, obtaining the best antibacterial activity against the Gram-negative bacteria E. coli of 21 ± 2% and 34 ± 6% for the highest concentration of MgO and Mg(OH)2 NPs, respectively.

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Section: Resultsmentioning

confidence: 99%

Bioactivity and Antibacterial Analysis of Plasticized PLA Electrospun Fibers Reinforced with MgO and Mg(OH)2 Nanoparticles

Leonés,

Salaris,

Peponi

et al. 2024

Polymers

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Comparative Degradation Behavior of Carbonate Apatite-Coated and Hydroxyapatite-Coated Mg-Ca Alloy Plates and Screws in Rabbit Femurs

Hiromoto,

Nozoe,

Hanada

et al. 2024

Biomedical Materials & Devices

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Efficient Bioactive Surface Coatings with Calcium Minerals: Step-Wise Biomimetic Transformation of Vaterite to Carbonated Apatite

Kim,

Min,

Pack

2024

Biomimetics

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Carbonated apatite (CAp), known as the main mineral that makes up human bone, can be utilized in conjunction with scaffolds to increase their bioactivity. Various methods (e.g., co-precipitation, hydrothermal, and biomimetic coatings) have been used to provide bioactivity by forming CAp on surfaces similar to bone minerals. Among them, the use of simulated body fluids (SBF) is the most popular biomimetic method for generating CAp, as it can provide a mimetic environment. However, coating methods using SBF require at least a week for CAp formation. The long time it takes to coat biomimetic scaffolds is a point of improvement in a field that requires rapid regeneration. Here, we report a step-wise biomimetic coating method to form CAp using calcium carbonate vaterite (CCV) as a precursor. We can manufacture CCV-transformed CAp (V-CAp) on the surface in 4 h at least by immersing CCV in a phosphate solution. The V-CAp deposited surface was analyzed using scanning electron microscopy (SEM) images according to the type of phosphate solutions to optimize the reaction conditions. X-ray diffraction (XRD) and attenuated total reflection-Fourier transform infrared (ATR-FTIR) analysis validated the conversion of CCV to V-CAp on surfaces. In addition, the bioactivity of V-CAp coating was analyzed by the proliferation and differentiation of osteoblasts in vitro. V-CAp showed 2.3-folded higher cell proliferation and 1.4-fold higher ALP activity than the glass surface. The step-wise method of CCV-transformed CAp is a biocompatible method that allows the environment of bone regeneration and has the potential to confer bioactivity to biomaterial surfaces, such as imparting bioactivity to non-bioactive metal or scaffold surfaces within one day. It can rapidly form carbonated apatite, which can greatly improve time efficiency in research and industrial applications.

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Carbonate content control in carbonate apatite coatings of biodegradable magnesium

Cited by 3 publications

References 46 publications

Bioactivity and Antibacterial Analysis of Plasticized PLA Electrospun Fibers Reinforced with MgO and Mg(OH)2 Nanoparticles

Bioactivity and Antibacterial Analysis of Plasticized PLA Electrospun Fibers Reinforced with MgO and Mg(OH)2 Nanoparticles

Comparative Degradation Behavior of Carbonate Apatite-Coated and Hydroxyapatite-Coated Mg-Ca Alloy Plates and Screws in Rabbit Femurs

Efficient Bioactive Surface Coatings with Calcium Minerals: Step-Wise Biomimetic Transformation of Vaterite to Carbonated Apatite

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