Carbon tetrachloride metabolism in sheep and in <i>Fasciola hepatica</i>

Fowler, John

doi:10.1111/j.1476-5381.1970.tb10367.x

Cited by 5 publications

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References 19 publications

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“…The mode of the fasciolifugal action of carbon tetrachloride is unknown, and may be an indirect effect mediated by metabolic products of the drug or materials produced by the liver when it is affected by the drug (Alexander & MacDonald, 1960;Kondos & McClymont, 1965;Khalidi & Zaki, 1969). In sheep considerable amounts of carbon tetrachloride are metabolized to chloroform, and the main products in the metabolism of hexachloroethane, another fasciolifuge, are pentachloroethane and tetrachloroethylene (Fowler, 1969;1970).…”

Section: Introductionmentioning

confidence: 99%

ACTIONS OF CARBON TETRACHLORIDE, HEXACHLOROETHANE AND THE PRODUCTS OF THEIR METABOLISM IN SHEEP ON Fasciola hepatica

Bartlet

1976

British J Pharmacology

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An in vitro preparation of Fasciola hepatica is described which responded to electrical stimulation with tetanic spasms. Both carbon tetrachloride (20–500 nl/ml), and its metabolite chloroform (50–1000 nl/ml), produced contractions in the preparation which extinguished the responses to electrical stimulation. It is suggested that the spasmogenic action of carbon tetrachloride and its metabolite may contribute to the fasciolifugal action of the drug. Hexachloroethane, another fasciolifuge, had very little effect in the preparation. However, penta‐chloroethane and tetrachloroethylene, the main products of the metabolism of hexachloroethane in sheep, were potent spasmogens in preparations of Fasciola hepatica. Pentachloroethane was about twice as potent as carbon tetrachloride. Tetrodotoxin (2 μg/ml) did not antagonize the responses of the preparation to electrical stimulation or carbon tetrachloride.

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