Carbon source–dependent capsule thickness regulation in Streptococcus pneumoniae
Joel P. Werren,
Nadja Mostacci,
Ilche Gjuroski
et al.
Abstract:BackgroundThe polysaccharide capsule of Streptococcus pneumoniae plays a major role in virulence, adherence to epithelial cells, and overall survival of the bacterium in the human host. Galactose, mannose, and N-acetylglucosamine (GlcNAc) are likely to be relevant for metabolization in the nasopharynx, while glucose is the primary carbon source in the blood. In this study, we aim to further the understanding of the influence of carbon sources on pneumococcal growth, capsule biosynthesis, and subsequent adheren… Show more
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