Carbon quantum dots embedded electrospun nanofibers for efficient antibacterial photodynamic inactivation

Nie, Xiaolin; Wu, Shuanglin; Mensah, Alfred; Lu, Keyu; Wei, Qufu

doi:10.1016/j.msec.2019.110377

Cited by 61 publications

(50 citation statements)

References 91 publications

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“…Carbon quantum dots (CQDs), especially hetero-element doped CQDs with particle size of less than 10 nm, stand out in the eld of antibacterial research due to their advantageous properties including nontoxic nature, photostability, versatility in surface functionality for desired microbial adhesion and interactions, and their production from abundant and inexpensive precursors for extremely broad and low to ultralow cost applications [11][12][13][14][15][16] . At present, the mechanism of action of CQDs against bacteria mainly focuses on the three aspects of directly producing reactive oxygen species (ROS), such as superoxide (•O 2 − ) and hydroxyl radical (•OH) 17,18 , producing ROS assisted by photoactivation or other compound 6,[19][20][21] and damaging the cell membrane caused by the insertion of surface controlled CQDs through electrostatic interaction and/or hydrophobic interaction [22][23][24] . However, the above mechanism cannot further explain the signaling pathway of antibacterial CQDs against bacteria at the molecular level and there has been a lack of in-depth understanding of the interaction between such CQDs and bacteria.…”

Section: Introductionmentioning

confidence: 99%

Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria

Zhao

Wang

et al. 2020

Preprint

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Quaternized carbon quantum dots (qCQDs) with broad-spectrum antibacterial activity were synthesized by a simple green “one-pot” method using dimethyl diallyl ammonium chloride and glucose as reaction precursors. The qCQDs showed satisfactory antibacterial activity against both gram-positive and gram-negative bacteria. In rat models of wounds infected with mixed bacteria, qCQDs obviously restored the weight of rats, significantly reduced the death of rats from severe infection, and promoted the recovery and healing of infected wounds. Biosafety tests confirmed that qCQDs had no obvious toxic and side effects during the testing stage. The analysis of quantitative proteomics revealed that qCQDs mainly acted on the ribosomal proteins of gram-positive bacteria and significantly down-regulated the metabolization-related proteins of gram-negative bacteria. Real-time quantitative PCR verified the expression levels of genes corresponding to the proteins with significant differences expressed by the two species of bacteria after treated with qCQDs. The variation trend of the detected genes was consistent with the results of proteomics, meaning that qCQDs played the antibacterial effect on bacteria with a new antibacterial mechanism.

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Section: Introductionmentioning

confidence: 99%

Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria

Zhao

Wang

et al. 2020

Preprint

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“…Wang et al [9] developed a linear tetrapyrrole metal complex, which possessed a thiol functionality to facilitate conjugation to near infrared-absorbing gold nanoshells, as a PS for PDT against triple-negative breast cancer cells. Nie et al [10] used electrospinning technology to fabricate nanofibers that combined polyacrylonitrile and biocompatible carbon quantum dots for antibacterial photodynamic inactivation. Broad antibacterial efficacy of the proposed nanofibers was confirmed by experiments.…”

Section: Introductionmentioning

confidence: 99%

Dual-acting antibacterial porous chitosan film embedded with a photosensitizer

Liu

Lin

Lee

et al. 2020

Science and Technology of Advanced Materials

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This study proposes to develop a dual-acting antibacterial film of porous chitosan (Cs) embedded with small molecular compound, which possesses photosensitive characteristics with bactericidal efficacy, to promote the accelerated recovery of infectious wounds. The Cs/small molecular compound (Cs-cpd.2) dressing was prepared using the freeze-drying method. Characterization of the synthesized Cs-cpd.2 indicated that it has high porosity and moisture absorption effect, hence enhancing the absorption of wound exudate. Experimental results showed that Cs-cpd.2 dressing has good bactericidal and bacteriostatic effects on Staphylococcus aureus under visiblelight irradiation and has antibacterial effect in the dark. It was also found that the small molecular compound does not have cytotoxicity at a dose of 0-5 μM. Furthermore, Cs-cpd.2 that contained small molecular compound with a concentration of 0.3-1 μM has positive effect on both the cell viability rate and cell proliferation rate of human fibroblast CG1639. Cs-cpd.2 can significantly promote cell proliferation when the small molecular compound and the basic fibroblast growth factor bFGF were added together. Therefore, the proposed Cs-cpd.2 dressing is feasible for photodynamic therapy (PDT) and clinical wound dressing applications.

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“…and photostable 5,6 and can be easily dispersed in water and organic solvents. 2,4 In addition to that, CDs can be obtained from low-cost precursors such as citric acid, groundnut, silk-sericin, and silk, 5,7,8 and by following facile synthesis routes. 4 An exciting feature of CDs is the ability to emit fluorescence at determined wavelengths.…”

mentioning

confidence: 99%

“…2,4 In addition to that, CDs can be obtained from low-cost precursors such as citric acid, groundnut, silk-sericin, and silk, 5,7,8 and by following facile synthesis routes. 4 An exciting feature of CDs is the ability to emit fluorescence at determined wavelengths. [4][5][6] The fundamental factor behind CD photoluminescent behavior (PL) is not entirely elucidated.…”

mentioning

confidence: 99%

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Biocompatible and fluorescent polycaprolactone/silk electrospun nanofiber yarns loaded with carbon quantum dots for biotextiles

Cotrim

Oréfice

2020

Polymers for Advanced Techs

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Carbon quantum dots (CDs) are attractive nanoparticles for several applications, due to inherent properties such as excitation dependent photoluminescence emission and chemical stability. In the present work, we synthesized CDs from silk (Bombyx Mori) by a microwave-assisted method. The resultant spherical nanoparticles with high fluorescence under UV light were incorporated into PCL/silk matrix and electrospun into continuous nanofiber yarns (NF-Ys) by a one-step method. Besides granting yarns fluorescence, CD inclusion contributed to a decrease in fiber diameter and an increase in strength by 2.7-fold. Cell viability studies with mammalian lung cell lines show viability above 80%, suggesting good biocompatibilty. Such yarns show the potential to be assembled into larger structures such as biotextiles, with possible multifunctionalities such as antiviral, antibacterial, and biosensing applications.

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Carbon quantum dots embedded electrospun nanofibers for efficient antibacterial photodynamic inactivation

Cited by 61 publications

References 91 publications

Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria

Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria

Dual-acting antibacterial porous chitosan film embedded with a photosensitizer

Biocompatible and fluorescent polycaprolactone/silk electrospun nanofiber yarns loaded with carbon quantum dots for biotextiles

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