Carbon Quantum Dots Derived from Herbal Medicine as Therapeutic Nanoagents for Rheumatoid Arthritis with Ultrahigh Lubrication and Anti-inflammation

Qiang, Ruibin; Huang, Hongtao; Chen, Jia; Shi, Xianzhe; Fan, Zengjie; Xu, Guowang; Qiu, Hongdeng

doi:10.1021/acsami.3c06188

Cited by 15 publications

(7 citation statements)

References 62 publications

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“…It was found that CQDs obtained from herbal medicines greatly reduced swelling signs and impeded the production of associated inflammation cytokines (IL-1, IL-6, and TNF-α), demonstrating exceptional anti-inflammation efficacy. 561 Liu et al suggested HIF-1 siRNA-carried calcium phosphate NPs enclosed in high-density lipoprotein-modified with apolipoprotein E3 (HIF-CaP-rHDL) as a treatment for RA in order to suppress the levels of HIF-1, NF-κB, and MAPK. By blocking these pro-inflammatory signaling pathways and attenuating cytokines including TNF-α, IL-1β, and IL-6, HIF-CaP-rHDL showed promise as a targeted remedy for RA.…”

Section: Nanotechnology In Non-infectious Inflammatory Diseasesmentioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

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Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergence of new pathogens, increasing drug resistance, changes in living environments and lifestyles, and the aging population. Despite rapid advancements in mechanistic research and drug development for these diseases, current treatments often have limited efficacy and notable side effects, necessitating the development of more effective and targeted anti-inflammatory therapies. In recent years, the rapid development of nanotechnology has provided crucial technological support for the prevention, treatment, and detection of inflammation-associated diseases. Various types of nanoparticles (NPs) play significant roles, serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and bioavailability. NPs can also directly combat pathogens and inflammation. In addition, nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory diseases. This review categorizes and characterizes different types of NPs, summarizes their applications in the prevention, treatment, and detection of infectious and inflammatory diseases. It also discusses the challenges associated with clinical translation in this field and explores the latest developments and prospects. In conclusion, nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

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Section: Nanotechnology In Non-infectious Inflammatory Diseasesmentioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

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“…New nanoagents for rheumatoid arthritis treatment could be developed by combining the lubricating and anti-inflammatory bioefficacy of CQDs generated from herbal medicine (Fig. 14 ) 147 .…”

Section: Nanotheranostics For Multiple Disease Of Herbal Bioactivesmentioning

confidence: 99%

Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules

Setia,

Vallamkonda,

Challa

et al. 2024

Nanotheranostics

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Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they can be used. Since the herbal remedy is given through a dated and ineffective method of drug administration, its effectiveness is diminished. The novel form of medicine delivery has the potential to increase the effectiveness of herbal substances while decreasing their side effects. This is the main idea behind utilising different ways of drug delivery in herbal treatments. Several benefits arise from novel formulations of herbal compounds as compared to their conventional counterparts. These include enhanced penetrating ability into tissues, constant delivery of effective doses, and resistance to physical and chemical degradation. Controlled and targeted delivery that include herbal components allow for more traditional dosing while simultaneously increasing their efficacy. Enhancing the biodistribution and target site accumulation of systemically administered herbal medicines is the goal of nanomedicine formulations. The field of nanotheranostics has made significant advancements in the development of herbal compounds by combining diagnostic and therapeutic functions on a single nanoscale platform. It is critically important to create a theranostic nanoplatform that is derived from plants and is intrinsically "all-in-one" for single molecules. In addition to examining the mechanistic approach to nanoparticle synthesis, this review highlights the therapeutic effects of nanoscale phytochemical delivery systems. Furthermore, we have evaluated the scope for future advancements in this field, discussed several nanoparticles that have been developed recently for herbal imaging, and provided experimental evidence that supports their usage.

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“…Medicinal plants for RA treatment have gained attention due to their potential therapeutic benefits and fewer side effects compared to conventional drugs [ 8 ]. Various plants with anti-inflammatory, analgesic, and immunomodulatory properties have been traditionally employed to alleviate RA symptoms.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Therapeutic Potential of Ammodaucus leucotrichus Seed Extracts: A Multi-Faceted Analysis of Phytochemical Composition, Anti-Inflammatory Efficacy, Predictive Anti-Arthritic Properties, and Molecular Docking Insights

Djehiche,

Benzidane,

Djeghim

et al. 2024

Pharmaceuticals

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Ammodaucus leucotrichus exhibits promising pharmacological activity, hinting at anti-inflammatory and anti-arthritic effects. This study investigated seed extracts from Ammodaucus leucotrichus using methanol and n-hexane, focusing on anti-inflammatory and anti-arthritic properties. The methanol extract outperformed the n-hexane extract and diclofenac, a reference anti-inflammatory drug, in trypsin inhibition (85% vs. 30% and 64.67% at 125 μg/mL). For trypsin inhibition, the IC50 values were 82.97 μg/mL (methanol), 202.70 μg/mL (n-hexane), and 97.04 μg/mL (diclofenac). Additionally, the n-hexane extract surpassed the methanol extract and diclofenac in BSA (bovine serum albumin) denaturation inhibition (90.4% vs. 22.0% and 51.4% at 62.5 μg/mL). The BSA denaturation IC50 values were 14.30 μg/mL (n-hexane), 5408 μg/mL (methanol), and 42.30 μg/mL (diclofenac). Gas chromatography–mass spectrometry (GC–MS) revealed 59 and 58 secondary metabolites in the methanol and n-hexane extracts, respectively. The higher therapeutic activity of the methanol extract was attributed to hydroxyacetic acid hydrazide, absent in the n-hexane extract. In silico docking studies identified 28 compounds with negative binding energies, indicating potential trypsin inhibition. The 2-hydroxyacetohydrazide displayed superior inhibitory effects compared to diclofenac. Further mechanistic studies are crucial to validate 2-hydroxyacetohydrazide as a potential drug candidate for rheumatoid arthritis treatment.

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Carbon Quantum Dots Derived from Herbal Medicine as Therapeutic Nanoagents for Rheumatoid Arthritis with Ultrahigh Lubrication and Anti-inflammation

Cited by 15 publications

References 62 publications

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules

Exploring the Therapeutic Potential of Ammodaucus leucotrichus Seed Extracts: A Multi-Faceted Analysis of Phytochemical Composition, Anti-Inflammatory Efficacy, Predictive Anti-Arthritic Properties, and Molecular Docking Insights

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