Carbon quantum dots derived from lysine and arginine simultaneously scavenge bacteria and promote tissue repair

Li, Peili; Han, Fengxuan; Cao, Weiwei; Zhang, Gaoke; Li, Jiaying; Zhou, Jinwei; Gong, Xuedong; Turnbull, Gareth; Shu, Wenmiao; Xia, Lunguo; Fang, Bing; Xing, Xiaodong; Li, Bin

doi:10.1016/j.apmt.2020.100601

Cited by 71 publications

(74 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Highresolution TEM (HRTEM) showed that the well-resolved lattice fringe with intercrystalline spacings of qCQDs was 0.22 nm ( Fig. 1b), corresponding to the (100) facets of graphitic carbon 18,32 . The particle size of qCQDs measured by dynamic light scattering (DLS) was centered at 4.5 nm with relatively concentrated distribution, suggesting the consistent and uniform morphology of qCQDs con rmed from…”

Section: Resultsmentioning

confidence: 99%

“…Carbon quantum dots (CQDs), especially hetero-element doped CQDs with particle size of less than 10 nm, stand out in the eld of antibacterial research due to their advantageous properties including nontoxic nature, photostability, versatility in surface functionality for desired microbial adhesion and interactions, and their production from abundant and inexpensive precursors for extremely broad and low to ultralow cost applications [11][12][13][14][15][16] . At present, the mechanism of action of CQDs against bacteria mainly focuses on the three aspects of directly producing reactive oxygen species (ROS), such as superoxide (•O 2 − ) and hydroxyl radical (•OH) 17,18 , producing ROS assisted by photoactivation or other compound 6,[19][20][21] and damaging the cell membrane caused by the insertion of surface controlled CQDs through electrostatic interaction and/or hydrophobic interaction [22][23][24] . However, the above mechanism cannot further explain the signaling pathway of antibacterial CQDs against bacteria at the molecular level and there has been a lack of in-depth understanding of the interaction between such CQDs and bacteria.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria

Zhao

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Quaternized carbon quantum dots (qCQDs) with broad-spectrum antibacterial activity were synthesized by a simple green “one-pot” method using dimethyl diallyl ammonium chloride and glucose as reaction precursors. The qCQDs showed satisfactory antibacterial activity against both gram-positive and gram-negative bacteria. In rat models of wounds infected with mixed bacteria, qCQDs obviously restored the weight of rats, significantly reduced the death of rats from severe infection, and promoted the recovery and healing of infected wounds. Biosafety tests confirmed that qCQDs had no obvious toxic and side effects during the testing stage. The analysis of quantitative proteomics revealed that qCQDs mainly acted on the ribosomal proteins of gram-positive bacteria and significantly down-regulated the metabolization-related proteins of gram-negative bacteria. Real-time quantitative PCR verified the expression levels of genes corresponding to the proteins with significant differences expressed by the two species of bacteria after treated with qCQDs. The variation trend of the detected genes was consistent with the results of proteomics, meaning that qCQDs played the antibacterial effect on bacteria with a new antibacterial mechanism.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria

Zhao

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…On the contrary, Lys-CQDs and Arg-CQDs promoted the growth of mammalian cells and no hemolysis to red blood cells in vitro. In vivo, both systems significantly inhibited bacterial growth and accelerated wound healing in infected wounds in mice [178]. These systems could lead to different clinical applications of CQDs to eradicate bacteria and promote tissue repair.…”

Section: Carbon Nanotubes Graphene Fullerenesmentioning

confidence: 94%

“…The latest studies in carbon-based nanomaterials, such as graphene, fullerene, carbon quantum dots (CQDs), and carbon nanotubes (CNT) have attracted increasing interest due to their potency in combating infections, while some reports suggest an acceptable toxicity toward mammalian cells and tissues [ 178 , 179 ]. In addition to their antimicrobial potency, carbon-based nanomaterials are very attractive for drug delivery [ 43 ].…”

Section: Nanotechnological Platforms and Scaffolds For Peptide Delmentioning

confidence: 99%

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

2020

View full text Add to dashboard Cite

Bacterial infections occur when wound healing fails to reach the final stage of healing, which is usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site, which is accompanied very often by increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases. AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies that are used to combat infection and modulate the healing rate—such as polymers, scaffolds, films and wound dressings, and organic and inorganic nanoparticles—have been discussed as well. New technologies such as Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated protein (CRISPR-Cas) are taken into consideration as potential future tools for AMP delivery in skin therapy.

show abstract

“…Latest studies in carbon-based nanomaterials, such as graphene, fullerene, carbon quantum dots (CQDs) and carbon nanotubes (CNT) have attracted an increasing interest due to their potency in combating infections while some reports suggest an acceptable toxicity towards mammalian cells and tissues [149,150]. In addition, in addition to their antimicrobial potency, carbon-based nanomaterials are very attractive for drug delivery [34].…”

Section: Carbon Nanotubes Graphene Fullerenesmentioning

confidence: 99%

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

Patrulea¹,

Borchard²,

Jordan³

2020

Preprint

View full text Add to dashboard Cite

Bacterial infections occur when wound healing fails to reach the final stage of healing, usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site accompanied very often by an increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases. AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies, such as polymers, scaffolds, films and wound dressings, organic and inorganic nanoparticles, to combat infection and modulate the healing rate have been discussed as well. New technologies such as CRISPR-Cas are taken into consideration as potential future tools for AMP delivery in skin therapy.

show abstract

Carbon quantum dots derived from lysine and arginine simultaneously scavenge bacteria and promote tissue repair

Cited by 71 publications

References 51 publications

Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria

Quaternized carbon quantum dots with broad-spectrum antibacterial activity for treatment of wounds infected with mixed bacteria

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

Contact Info

Product

Resources

About