Carbon quantum dots: A promising nanocarrier for bioimaging and drug delivery in cancer

Jana, Pradip; Dev, Abhimanyu

doi:10.1016/j.mtcomm.2022.104068

Cited by 48 publications

(31 citation statements)

References 216 publications

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“…Additionally, numerous studies have identified and approved uniquely targeted CDs, which are cancer cell markers for a variety of specific malignancies, allowing both their unique use in self-targeted bio-imaging and potential methods for cancer diagnosis [ 73 ]. The discovery of CDs is considered a powerful new class of nanoprobes and has been demonstrated to be utilized as a contrast agent in numerous bio-imaging models [ 74 ]. The ideal CDs for bio-imaging would have high PL quantum yield (QY) [ 75 ], long-wavelength PL emission [ 76 , 77 ], little toxicity or nontoxicity [ 78 ], and renal cleavability [ 79 ].…”

Section: Cds As Cancer Bio-imaging Agentsmentioning

confidence: 99%

Carbon Dots: Opportunities and Challenges in Cancer Therapy

2023

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Recently, carbon dots (CDs) have been actively studied and reported for their various properties. In particular, the specific characteristics of carbon dots have been considered as a possible technique for cancer diagnosis and therapy. This is also a cutting-edge technology that offers fresh ideas for treating various disorders. Though carbon dots are still in their infancy and have not yet shown their value to society, their discovery has already resulted in some noteworthy advancements. The application of CDs indicates conversion in natural imaging. Photography using CDs has demonstrated extraordinary appropriateness in bio-imaging, the discovery of novel drugs, the delivery of targeted genes, bio-sensing, photodynamic therapy, and diagnosis. This review seeks to provide a comprehensive understanding of CDs, including their benefits, characteristics, applications, and mode of action. In this overview, many CD design strategies will be highlighted. In addition, we will discuss numerous studies on cytotoxic testing to demonstrate the safety of CDs. The current study will address the production method, mechanism, ongoing research, and application of CDs in cancer diagnosis and therapy.

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Section: Cds As Cancer Bio-imaging Agentsmentioning

confidence: 99%

Carbon Dots: Opportunities and Challenges in Cancer Therapy

2023

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“…In addition to CQDs ultrasmall size, shape, solubility, and biocompatibility, they can be triggered by external stimuli such as pH, temperature, ultrasound, and near-infrared (NIR) light for the controlled release of drugs, all of which are added advantages in nanomedicine and future theranostics applications [ 82 ]. Moreover, the CQDs have excellent biodistribution with great biocompatibility compared with other nanomaterials [ 83 ]. Hence, we are anticipating that the GOQDs presented in the study will provide an important contribution in cancer diagnosis and therapy.…”

Section: Resultsmentioning

confidence: 99%

Green Synthesis of Blue-Emitting Graphene Oxide Quantum Dots for In Vitro CT26 and In Vivo Zebrafish Nano-Imaging as Diagnostic Probes

et al. 2023

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Graphene oxide quantum dots (GOQDs) are prepared using black carbon as a feedstock and H2O2 as a green oxidizing agent in a straightforward and environmentally friendly manner. The process adopted microwave energy and only took two minutes. The GOQDs are 20 nm in size and have stable blue fluorescence at 440 nm. The chemical characteristics and QD morphology were confirmed by thorough analysis using scanning electron microscope (SEM), transmission electron microscope (TEM), atomic force microscope (AFM), Fourier transmission infra-red (FT-IR), and X-ray photoelectron spectroscopy (XPS). The biocompatibility test was used to evaluate the toxicity of GOQDs in CT26 cells in vitro and the IC50 was found to be 200 µg/mL with excellent survival rates. Additional in vivo toxicity assessment in the developing zebrafish (Danio rerio) embryo model found no observed abnormalities even at a high concentration of 400 μg/mL after 96 h post fertilization. The GOQDs luminescence was also tested both in vitro and in vivo. They showed excellent internal distribution in the cytoplasm, cell nucleus, and throughout the zebrafish body. As a result, the prepared GOQDs are expected to be simple and inexpensive materials for nano-imaging and diagnostic probes in nanomedicine.

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“…Upon illumination by visible light, e – located in the VB of BiOBr are excited and then transfer to CB, leaving h + in the VB. After coupling with Bi-N-CDs, e – accumulated in the CB of BiOBr can migrate to the surface of Bi-N-CDs with a conjugated π structure . This augmented the separation of e – –h + pairs in BiOBr and prolonged their lifetime.…”

Section: Resultsmentioning

confidence: 99%

A Transparent, High-Strength, and Recyclable Core–Shell Structured Wood Hydrogel Integrated with Carbon Dots for Photodegradation of Rhodamine B

Yue

2023

ACS Appl. Nano Mater.

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The opacity, fragility, and environmental unfriendliness of the traditional photocatalytic matrix cannot fully utilize the properties of photocatalysts and efficiently degrade pollutants. In this work, a transparent wood hydrogel with a core–shell structure was developed using transparent wood (TW) impregnated with polyacrylic acid (PAA) as the core layer and Bi-N-carbon dots/BiOBr (Bi-N-CDs/BiOBr) photocatalyst-initiated polymerization of acrylic acid (AA) monomers as the shell layer. In the shell layer, nanoscale CDs with rich hydrophilic groups built a link between BiOBr and PAA and strengthened the adsorption–photocatalysis synergistic removal for RhB. The original wood backbone well conserved during preparation led to an anisotropic structure in the resultant Bi-N-CDs/BiOBr@TW photocatalytic wood hydrogel. Namely, after introducing Bi-N-CDs/BiOBr as the linker and reinforcing agent, the tensile strength was up to 3.2 and 11.03 MPa along the radial (R-) and axial (A-) directions, which was 1.6- and 1.06-fold of R-TW and A-TW, respectively. Hence, Bi-N-CDs/BiOBr@TW with high strength furnishes multiple separations and reutilizations, and the RhB removal rate is approximately 85% after five cycles. The Bi-N-CDs/BiOBr@TW exhibited light transmittance up to 64.6 and 52.3% at 800 nm along the R- and A-directions, respectively. Moreover, the adsorption–photocatalysis synergistic rate of Bi-N-CDs/BiOBr@TW reached 93% in 300 min at pH = 7. This paper offers a strategy for fabricating wood hydrogels with outstanding stretchability, transparency, dye removal efficiency, and recyclability, opening a significant route for alleviating dye pollution.

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Carbon quantum dots: A promising nanocarrier for bioimaging and drug delivery in cancer

Cited by 48 publications

References 216 publications

Carbon Dots: Opportunities and Challenges in Cancer Therapy

Carbon Dots: Opportunities and Challenges in Cancer Therapy

Green Synthesis of Blue-Emitting Graphene Oxide Quantum Dots for In Vitro CT26 and In Vivo Zebrafish Nano-Imaging as Diagnostic Probes

A Transparent, High-Strength, and Recyclable Core–Shell Structured Wood Hydrogel Integrated with Carbon Dots for Photodegradation of Rhodamine B

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