Carbon Paste Modified with Peony‐Like CuO : Tb³⁺Nanostructures for the Simultaneous Determination of Sumatriptan and Naproxen in Biological and Pharmaceutical Samples

Abstract

This work studied a new carbon paste electrode modified with peony‐like CuO : Tb3+ nanostructure (P−L CuO : Tb3+ NS/CPE) for electrochemical detection of sumatriptan and naproxen using cyclic voltammetry, chronoamperometry and differential pulse voltammetry. Based on the findings, there was an improvement in the voltammetric behavior of sumatriptan and naproxen on the P−L CuO : Tb3+ NS/CPE surface when comparing with the bare CPE. The correlation of oxidation currents with the pH value, concentration and sweep rate of supporting electrolyte were determined for the optimization of conditions to detect the sumatriptan and naproxen. The surfaces of modified and unmodified electrodes were characterized as well. The diffusion‐control processes were confirmed on the basis of anodic peak findings. The results also revealed a two‐electron transfer process. The sumatriptan and naproxen were co‐detected via the modified electrode, with a range of 0.01‐800 μM and 0.01–700 μM respectively, and a detection limit of 3.3 nM and 2.7 nM, sequentially. An accuracy was found by the differential pulse voltammetry for co‐detection of these two drugs in pharmaceutical preparations and pathological specimens. In conclusion, we suggest the proposed approach for electrical determinations in the management of environmental contamination and industrial quality because of its unique properties like facile sample preparation, and appreciable sensitivity, repeatability and reproducibility.

Recent Advances on Electrochemical Sensors for Detection of Contaminants of Emerging Concern (CECs)

“…The linear ranges of detection were 4.00 nM to 350.00 µM for NAP and from 6.00 nM to 380.00 µM for SUM. Yet another electrode developed for the simultaneous detection of NAP and SUM was a carbon paste electrode modified with peony-like CuO-Tb 3+ nanostructures (P-L CuO: Tb 3+ NS/CPE) [67]. P-L CuO: Tb 3+ NS/CPE gave linear ranges of 0.01-800 µM and 0.01-700 µM, and detection limits of 3.3 nM and 2.7 nM for the detection of SUM and NAP, respectively.…”