Carbon Nanotubes in the Delivery of Anticancer Herbal Drugs

Jogi, Hardi; Maheshwari, Rahul; Raval, Nidhi; Kuche, Kaushik; Tambe, Vishakha; Mak, Kit‐Kay; Pichika, Mallikarjuna Rao; Tekade, Rakesh K.

doi:10.2217/nnm-2017-0397

Cited by 33 publications

(11 citation statements)

References 145 publications

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“…In this context, an appropriate delivery system is essential for the delivery of these herbal biomolecules, especially to the tumor area. To succeed this aim, carbon nanotubes (CNTs) have been extensively researched to distribute anticancer herbal molecules with developed treatment efficacy and safety [ 43 ]. Lately, many multifunctional delivery systems have been synthesized to use different agents, including micelles, liposomes and inorganic nanoparticles.…”

Section: Main Textmentioning

confidence: 99%

The nanocomposites designs of phytomolecules from medicinal and aromatic plants: promising anticancer-antiviral applications

Kaplan

2022

Beni-Suef Univ J Basic Appl Sci

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Background Nowadays, researchers are moving toward a herbal approach to cancer treatment because of the harmful effects of synthetic anti-tumor drugs. The evaluation of active compounds with plant origin may help in the remedy of human illnesses in the future. These active compounds have direct or indirect curative efficacies on difficult to cure diseases such as cancer. Investigation of nanoforms of these active compounds is one of the curious topics of the scientific community. Main body Saffron and its components obtained from Crocus sativa, essential oils obtained from lavender, Syzygium aromaticum called cloves and Beta vulgaris are known for their anticancer effects. Nano-drugs are designed to increase the anticancer activity of plant-derived drugs. Herbal extracts operate very great in the production of nanoparticles. The aim is to ensure that only the nano-drug is delivered to the tumor site. Furthermore, nanoparticles have hazardous effects when analyzed at elevated doses, but this issue can be doped together with plant extracts. Short conclusions The nanocomposites (graphene oxide, solid lipid nano and nanoemulsion) of phytomolecules obtained from saffron, clove, lavender and red beet may be effective in minimizing these toxic effects. In the near future, detecting the anticancer molecular mechanisms of these naturally derived compounds and nanocomposites could contribute to further cancer research. Apart from these, these compounds and its nanocomposites could have antiviral effects against today's threat covid-19 virus. Consequently, more promising anticancer and antiviral agents would be discovered. Graphical abstract

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Section: Main Textmentioning

confidence: 99%

The nanocomposites designs of phytomolecules from medicinal and aromatic plants: promising anticancer-antiviral applications

Kaplan

2022

Beni-Suef Univ J Basic Appl Sci

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“…Curcumin is extracted from the rhizome of Curcuma longa (Zingiberaceae). It possesses a proven anticancer activity, and at the same time, it demonstrated cyto-protective potential towards healthy cells [77]. Up to date, there is a dozen published studies on the combination of curcumin and CNTs [78,79].…”

Section: Carbon Nanotubes In Cancer Treatmentmentioning

confidence: 99%

The Advances in Biomedical Applications of Carbon Nanotubes

Saliev

2019

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Unique chemical, physical, and biological features of carbon nanotubes make them an ideal candidate for myriad applications in industry and biomedicine. Carbon nanotubes have excellent electrical and thermal conductivity, high biocompatibility, flexibility, resistance to corrosion, nano-size, and a high surface area, which can be tailored and functionalized on demand. This review discusses the progress and main fields of bio-medical applications of carbon nanotubes based on recently-published reports. It encompasses the synthesis of carbon nanotubes and their application for bio-sensing, cancer treatment, hyperthermia induction, antibacterial therapy, and tissue engineering. Other areas of carbon nanotube applications were out of the scope of this review. Special attention has been paid to the problem of the toxicity of carbon nanotubes.

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“…CNTs have been extensively investigated for their potential to deliver anticancer herbal compounds with better therapeutic effectiveness and safety ( 213 ). CNTs have been used in both therapeutic and environmental settings.…”

Section: Drug Delivery Systems Entrapping Natural Bioactive Compounds...mentioning

confidence: 99%

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

et al. 2022

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Cancer is a prominent cause of mortality globally, and it becomes fatal and incurable if it is delayed in diagnosis. Chemotherapy is a type of treatment that is used to eliminate, diminish, or restrict tumor progression. Chemotherapeutic medicines are available in various formulations. Some tumors require just one type of chemotherapy medication, while others may require a combination of surgery and/or radiotherapy. Treatments might last from a few minutes to many hours to several days. Each medication has potential adverse effects associated with it. Researchers have recently become interested in the use of natural bioactive compounds in anticancer therapy. Some phytochemicals have effects on cellular processes and signaling pathways with potential antitumor properties. Beneficial anticancer effects of phytochemicals were observed in both in vivo and in vitro investigations. Encapsulating natural bioactive compounds in different drug delivery methods may improve their anticancer efficacy. Greater in vivo stability and bioavailability, as well as a reduction in undesirable effects and an enhancement in target-specific activity, will increase the effectiveness of bioactive compounds. This review work focuses on a novel drug delivery system that entraps natural bioactive substances. It also provides an idea of the bioavailability of phytochemicals, challenges and limitations of standard cancer therapy. It also encompasses recent patents on nanoparticle formulations containing a natural anti-cancer molecule.

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Carbon Nanotubes in the Delivery of Anticancer Herbal Drugs

Cited by 33 publications

References 145 publications

The nanocomposites designs of phytomolecules from medicinal and aromatic plants: promising anticancer-antiviral applications

The nanocomposites designs of phytomolecules from medicinal and aromatic plants: promising anticancer-antiviral applications

The Advances in Biomedical Applications of Carbon Nanotubes

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

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