Carbon Nanotubes in Cancer Therapy and Drug Delivery

Elhissi, Abdelbary; Ahmed, Waqar; Hassan, Israr Ul; Dhanak, Vinod R.; D’Emanuele, Antony

doi:10.1155/2012/837327

Cited by 249 publications

(115 citation statements)

References 69 publications

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“…CNTs are promising materials for polymer composites [4][5][6] , energy conversion [7][8][9] , sensing [10][11][12] and biological application [13][14][15][16][17] . However, processing CNT´s and introducing them into real applications is severely limited by their low solubilities in organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Structure of a carbon nanotube–dendrimer composite

et al. 2013

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Using all atomistic molecular dynamics (MD) simulations we report the microscopic picture of the nanotube-dendrimer complex for PAMAM dendrimer of generation 2 to 4 and carbon nanotube of chirality (6,5). We find compact wrapping conformations of dendrimer onto the nanotube surface for all the three generations of PAMAM dendrimer. The degree of wrapping is more for non-protonated dendrimer compared to the protonated dendrimer. For comparison we also study the interaction of another dendrimer, poly(propyl ether imine) (PETIM), with nanotube and show that PAMAM dendrimer interacts strongly as compared to PETIM dendrimer as is evident from the distance of closest approach as well as the number of close contacts between the nanotube and dendrimer. We also calculate the binding energy between the nanotube and the dendrimer using MM/PBSA methods and attribute the strong binding to the charge transfer between them. Dendrimer wrapping on CNT will make it soluble and can act as an efficient dispersing agent for nanotube.

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Section: Introductionmentioning

confidence: 99%

Structure of a carbon nanotube–dendrimer composite

et al. 2013

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“…Despite our patient's tumor size, her main symptom was epistaxis. The youngest patient diagnosed with sinonasal paraganglioma ever reported was an 8-year-old boy with swelling of the left side of the face and a mass in the left turbinate [20]. After him, our patient is the second youngest patient and the youngest female, with 16 years at diagnosis; however, she had a suggestive complaint for the previous 13 years.…”

Section: Discussionmentioning

confidence: 89%

“…These are all hypervascular tumors, with contrast enhancement, presenting the classic “salt-and-pepper” appearance and variable patterns of intensity on MRI [5,10,20,21,22,23,24,25,26,27,28,29,30,31,32]. …”

Section: Discussionmentioning

confidence: 99%

Nasal Cavity Paraganglioma: Literature Review and Discussion of a Rare Case

Vital¹,

Farias

Dias

et al. 2017

Biomed Hub

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Paragangliomas can be found from the skull base to the sacrum. Sinonasal paragangliomas are infrequent. A 16-year-old female reported spontaneous discrete bilateral epistaxis once a month beginning when she was 3 years of age. Computed tomography showed an expansive hypervascular mass occupying the right nasal cavity and nasopharynx. Sinonasal paragangliomas usually occur in middle-aged women. Radiologic investigation is essential for the diagnosis of sinonasal paragangliomas and evaluating extension of the lesion. Endoscopic and conventional approaches are effective, and preoperative embolization is paramount for reducing bleeding risk. Histopathological features cannot differentiate benign from malignant paragangliomas, and since metastasis may eventually occur, follow-up must be carried out for a long period of time.

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“…Pure MWCNTs are diamagnetic [24] and their magnetic steerability must be achieved by combining with ferro-or superparamagnetic components [25][26][27], for example, by decoration with Fe 3 O 4 [28] or Fe encapsulation (at the stage of c-CVD synthesis or via capillary forces as a posttreatment) [29]. Indeed, as c-CVD is a convenient and tunable one-step synthesis of Fe@MWCNTs, we decided to focus on effective loading of Fe@MWCNTs with chemotherapeutics representing various mechanisms of cytotoxicity and to anchor the drugs using different chemical routes.…”

Section: Introductionmentioning

confidence: 99%

Hybrids of Iron-Filled Multiwall Carbon Nanotubes and Anticancer Agents as Potential Magnetic Drug Delivery Systems: In Vitro Studies against Human Melanoma, Colon Carcinoma, and Colon Adenocarcinoma

Boncel

Pluta

Skonieczna

et al. 2017

Journal of Nanomaterials

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Cell type, morphology, and functioning are key variables in the construction of efficient "drug-vehicle" hybrids in magnetic drug delivery. Iron-encapsulated multiwall carbon nanotubes (Fe@MWCNTs) appear as promising candidates for theranostics due to in situ chemical catalytic vapor deposition (c-CVD) synthesis, straightforward organic functionalization, and nanoneedle (1D) behavior. Here, model hybrids were synthesized by exploring C-sp 2 chemistry ((1+2)-cycloaddition of nitrenes and amidation) of the outer MWCNT walls combined with anticancer agents, that is, 5-fluorouracil (5FU), purpurin (Purp), and 1,8-naphthalimide DNA intercalators (NIDIs), via linkers. Analyses of the Fe@MWCNT vehicles by SEM, TEM, and Raman spectroscopy revealed their morphology while Mössbauer spectroscopy confirmed the presence of encapsulated ferromagnetic iron-based nanodomains. Cytotoxicity of the hybrids was studied using a 24 h MTS assay combined with the apoptosis and life cycle assays against human melanoma (Me45), colon carcinoma (HCT116+), and colon adenocarcinoma (Caco-2). The cells had different sensitivity to the vehicles themselves as well as to the hybrids. MWCNT-based covalent hybrids of 5FU and Purp emerged as the most promising systems against Me45 and HCT116+ cell lines with the highest in vitro cytotoxicity and proapoptotic activity. Furthermore, nanotubes bearing 4-nitro-and 4-(N-morpholinyl)-1,8-naphthalimide DNA intercalators appear as a promising candidate for the treatment of Caco-2.

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Carbon Nanotubes in Cancer Therapy and Drug Delivery

Cited by 249 publications

References 69 publications

Structure of a carbon nanotube–dendrimer composite

Structure of a carbon nanotube–dendrimer composite

Nasal Cavity Paraganglioma: Literature Review and Discussion of a Rare Case

Hybrids of Iron-Filled Multiwall Carbon Nanotubes and Anticancer Agents as Potential Magnetic Drug Delivery Systems: In Vitro Studies against Human Melanoma, Colon Carcinoma, and Colon Adenocarcinoma

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