Carbon Nanotubes in Cancer Therapy and Drug Delivery

Elhissi, Abdelbary; Ahmed, Waqar; Dhanak, Vinod R.; Subramani, Karthikeyan

doi:10.1016/b978-1-4557-7862-1.00020-1

Cited by 55 publications

(45 citation statements)

References 68 publications

(62 reference statements)

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“…46 Nanotubes can, for example, deliver therapeutic molecules and DNA; [47][48][49] however, without modifications on their structure, they can induce an immune response. 50 Nygaard and collaborators demonstrated that in mice, the adjuvant effect of particles on allergic immune responses increases with decreasing particle size and increasing particle surface area, and that CNTs promote allergic responses in mice. 45 In this way, researchers face the challenge of modifying CNT surface to avoid evoking immune responses and to promote successful regeneration as part of a scaffold.…”

Section: Required Characteristics For a Desirable Scaffold And Its Immentioning

confidence: 99%

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Tonelli¹,

Santos²,

Gomes³

et al. 2012

IJN

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Abstract:In recent years, significant progress has been made in organ transplantation, surgical reconstruction, and the use of artificial prostheses to treat the loss or failure of an organ or bone tissue. In recent years, considerable attention has been given to carbon nanotubes and collagen composite materials and their applications in the field of tissue engineering due to their minimal foreign-body reactions, an intrinsic antibacterial nature, biocompatibility, biodegradability, and the ability to be molded into various geometries and forms such as porous structures, suitable for cell ingrowth, proliferation, and differentiation. Recently, grafted collagen and some other natural and synthetic polymers with carbon nanotubes have been incorporated to increase the mechanical strength of these composites. Carbon nanotube composites are thus emerging as potential materials for artificial bone and bone regeneration in tissue engineering.

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Section: Required Characteristics For a Desirable Scaffold And Its Immentioning

confidence: 99%

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Tonelli¹,

Santos²,

Gomes³

et al. 2012

IJN

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“…5 Particularly, they are attractive as transporters for the delivery of biomolecules and drugs. 6 Through appropriate functionalization, CNTs have been used as nanocarriers to transport anticancer drugs, genes, and proteins for chemotherapy. They have also been used as mediators for photothermal therapy (PTT) and photodynamic therapy (PDT) to directly destroy cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

214

106

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Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy.

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“…The CNTs formed are already functionalized and can be used directly in various applications like targeted drug delivery. In targeted drug delivery, CNTs need to be functionalized so that drug should be attached with it (Bianco et al 2005;Elhissi et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of functionalized CNTs using soya and milk protein

et al. 2013

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Nanotechnology is the study of the phenomenon and manipulation of matter at atomic and molecular scale to enhance their older property and generate several new properties. Carbon nanotubes (CNTs) are one of the most commonly mentioned building blocks of nanotechnology. CNTs are very prevalent in today's world of medical research and are being highly researched in the fields of efficient drug delivery and bio sensing methods for disease treatment and health monitoring. There are number of methods for synthesizing CNTs. This is a biological method for synthesis of CNTs in which protein is used as carbon source and amino acids present in protein form complex with metal salt. The CNTs synthesized are then characterized and functionalized using techniques such as transmission electron microscopy, Fourier transform infrared, nuclear magnetic resonance, ultra-violet visible spectroscopy, X-ray diffraction, etc. The properties of the synthesized CNTs are studied with the help of techniques such as thermo-gravimetric analysis, differential thermal analysis, and vibrating sample magnetometer, etc.

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Carbon Nanotubes in Cancer Therapy and Drug Delivery

Cited by 55 publications

References 68 publications

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering

Carbon nanotubes as cancer therapeutic carriers and mediators

Synthesis and characterization of functionalized CNTs using soya and milk protein

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