Carbon Nanotubes in Biomedicine and Biosensing

Zhu, Yuntian; Wang, Libing; Xu, Chuanlai

doi:10.5772/16558

Cited by 9 publications

(8 citation statements)

References 64 publications

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“…For example, many searchers have coupled CNTs with glucose-oxidase biosensors for blood sugar control in diabetic patient with higher accuracy and simpler manipulation than biosensors used alone [4, 26, 40]. Other CNT-enzyme biosensors such as CNT-based dehydrogenase biosensors or peroxidase and catalase biosensors have also been developed for different therapeutic monitoring and diagnostics [40, 41]. …”

Section: Applications Of Carbon Nanotubes In Pharmacy and Medicinementioning

confidence: 99%

“…Moreover, CNTs have been assayed to detect some organophosphoric pesticides by using acetylcholine esterase immobilized on CNT surface with electrochemical detection [26, 40, 41]. Owing to their length scale and unique structure, the use of CNTs as biosensor vehicle is highly recommended to develop sensitive techniques for diagnostics and analyses from the laboratory to the clinic.…”

Section: Applications Of Carbon Nanotubes In Pharmacy and Medicinementioning

confidence: 99%

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Carbon Nanotubes: Applications in Pharmacy and Medicine

Pham-Huy

Dramou

et al. 2013

BioMed Research International

382

230

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Carbon nanotubes (CNTs) are allotropes of carbon, made of graphite and constructed in cylindrical tubes with nanometer in diameter and several millimeters in length. Their impressive structural, mechanical, and electronic properties are due to their small size and mass, their strong mechanical potency, and their high electrical and thermal conductivity. CNTs have been successfully applied in pharmacy and medicine due to their high surface area that is capable of adsorbing or conjugating with a wide variety of therapeutic and diagnostic agents (drugs, genes, vaccines, antibodies, biosensors, etc.). They have been first proven to be an excellent vehicle for drug delivery directly into cells without metabolism by the body. Then other applications of CNTs have been extensively performed not only for drug and gene therapies but also for tissue regeneration, biosensor diagnosis, enantiomer separation of chiral drugs, extraction and analysis of drugs and pollutants. Moreover, CNTs have been recently revealed as a promising antioxidant. This minireview focuses the applications of CNTs in all fields of pharmacy and medicine from therapeutics to analysis and diagnosis as cited above. It also examines the pharmacokinetics, metabolism and toxicity of different forms of CNTs and discusses the perspectives, the advantages and the obstacles of this promising bionanotechnology in the future.

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Section: Applications Of Carbon Nanotubes In Pharmacy and Medicinementioning

confidence: 99%

Section: Applications Of Carbon Nanotubes In Pharmacy and Medicinementioning

confidence: 99%

Carbon Nanotubes: Applications in Pharmacy and Medicine

Pham-Huy

Dramou

et al. 2013

BioMed Research International

382

230

View full text Add to dashboard Cite

show abstract

“…Because of their appealing chemical and physical features, nanomaterials have the potential and promise to be used in regenerative medicine [68]. Implants are generally rejected because of the post-administration pain, and the attachment of nanotubes to proteins and amino acids has shown promise in preventing this rejection in some cases.…”

Section: Artificial Implantmentioning

confidence: 99%

Carbon Nanotube (CNTs): Structure, Synthesis, Purification, Functionalisation, Pharmacology, Toxicology, Biodegradation and Application as Nanomedicine and Biosensor

Patel

Parikh²,

Patel³

et al. 2021

TJOPAM

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It is well acknowledged that carbon nanotubes (CNTs) are a potential new class of nanomaterials for technological advancement. The recent discovery of diverse kinds of carbon nanostructures has sparked interest in the potential applications of these materials in a variety of disciplines. Numerous distinct carbon nanotube (CNT) production methods have been developed, and their characterisation, separation, and manipulation of individual CNTs are now possible. Structure, surface area, surface charge, size distribution, surface chemistry, aggregation state, and purity of the samples all have a significant impact on the reactivity of carbon nanotubes, as does the purity of the samples. Currently, carbon nanotubes (CNTs) are being successfully used in the medicinal, pharmaceutical, and biomedical fields because of their large surface area, which makes them capable of adsorbing or conjugating with a wide range of therapeutic and diagnostic substances (drugs, genes, vaccines, antibodies, biosensors, etc.). They were the first to demonstrate that they are a great vehicle for drug delivery straight into cells without the need for metabolic processing by the body. This paper discusses the different types, structures, and properties of CNTs, as well as CNT synthesis and purification methods, how to functionalize CNTs, and their application in medicinal, pharmaceutical, and biomedical fields, toxicological properties and their assessment, as well as in-vivo pharmacology and biodegradation pathways.

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“…CNTs have high thermal stability (up to 2800 °C in vacuum and about 750 °C in air), high surface area (200-900 m 2 g −1 ), low density (1-2 g cm −3 ), and high Young's modulus (1-1.8 TPa) [3,5,6]. These properties make CNTs useful for sensors [8,9], high strength materials [10], nanoelectronics [11,12], fuel storage [13], energy storage [14], and biomedicine [15][16][17][18]. Commercially available CNTs are typically produced by chemical vapor deposition [19][20][21], and are entangled and randomly oriented due to short-range van der Waals forces between adjacent CNTs.…”

Section: Carbon Nanotubesmentioning

confidence: 99%