Carbon nanotube reinforced polyvinyl alcohol/biphasic calcium phosphate scaffold for bone tissue engineering

Lan, Weiwei; Zhang, Xiumei; Xu, Mengjie; Zhao, Liqin; Huang, Di; Wei, Xiaochun; Chen, Weiyi

doi:10.1039/c9ra08569f

Cited by 45 publications

(30 citation statements)

References 39 publications

(57 reference statements)

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“…It is worth highlighting that the composite scaffolds prepared in this work combine a high apparent porosity (as high as 87.9 ± 1.0%) with significant mechanical stability (modulus of elasticity as large as 16 ± 3 MPa). These values are considerably higher than those already reported for PVA‐based scaffolds obtained by other fabrication techniques, 53–56 which reinforces both the great potential of the processing route used here and the benefits related to the incorporation of MWCNTs into the polymer matrix.…”

Section: Resultssupporting

confidence: 65%

Polyvinyl alcohol/multi‐walledcarbon nanotubes nanocomposites with ordered macroporous structures prepared byice‐templating

Guimarães

Lapér

Castro³

et al. 2020

J of Applied Polymer Sci

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We demonstrate in this study that it is possible to prepare three‐dimensionally ordered macroporous polymer structures by ice‐templating. Polyvinyl alcohol (PVA) was used as a model system in this study, but the processing route proposed here can be applied to other polymer systems. Multi‐walled carbon nanotubes (MWCNTs) were incorporated into the PVA matrix at concentrations up to 12 wt% to investigate the influence of this addition on the mechanical and electrical properties of the obtained scaffolds. Different freezing routes were used, namely unidirectional, radial, and bidirectional freezing. The addition of MWCNTs had a strengthening effect on the scaffolds, especially when added at loadings around 2 wt%. Samples prepared by unidirectional freezing displayed larger mechanical stability, but materials derived from radial and bidirectional freezing showed a higher electrical conductivity. The obtained materials exhibited apparent porosity above 85%, which can be of great interest in many applications.

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Section: Resultssupporting

confidence: 65%

Polyvinyl alcohol/multi‐walledcarbon nanotubes nanocomposites with ordered macroporous structures prepared byice‐templating

Guimarães

Lapér

Castro³

et al. 2020

J of Applied Polymer Sci

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“…On the contrary, β-TCP can be easily degraded in the body, activates bone conduction through micropores inside the body to form new bone, and is known to cause complete bone regeneration, because it does not remain in the tissue [ 17 ]. Biphasic calcium phosphate nanoparticles (BCP-NPs), which are a mixture of HA and β-TCP at 60/40 wt%, are known as a composite material that can compensate for the disadvantages of HA and β-TCP, which are synthetic bone materials [ 18 ]. Recently, a hydrogel system containing biphasic calcium phosphate has been studied for effective bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering

Choi

Kim

Byeon³

et al. 2021

Nanomaterials

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In the field of bone tissue, maintaining adequate mechanical strength and tissue volume is an important part. Recently, biphasic calcium phosphate (BCP) was fabricated to solve the shortcomings of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP), and it is widely studied in the field of bone-tissue engineering. In this study, a composite hydrogel was fabricated by applying BCP to gelatin methacrylate (GelMA). It was tested by using a mechanical tester, to characterize the mechanical properties of the prepared composite hydrogel. The fabricated BCP was analyzed through FTIR and XRD. As a result, a different characteristic pattern from hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) was observed, and it was confirmed that it was successfully bound to the hydrogel. Then, the proliferation and differentiation of preosteoblasts were checked to evaluate cell viability. The analysis results showed high cell viability and relatively high bone differentiation ability in the composite hydrogel to which BCP was applied. These features have been shown to be beneficial for bone regeneration by maintaining the volume and shape of the hydrogel. In addition, hydrogels can be advantageous for clinical use, as they can shape the structure of the material for custom applications.

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“…9,[21][22][23] Beyond natural polymers, minerals such as silicates, calcium phosphates, and hydroxyapatite (HA) have also been embedded into PVAbased hydrogel matrices to enhance their biological activity. 10,19,24 HA is the main mineral component of the natural bone matrix, showing an excellent osteoconductivity, affinity for adhesive proteins, and induces osteoblast differentiation. [25][26][27] In parallel, recent studies have addressed the critical role that strontium (Sr) may have on bone metabolism.…”

mentioning

confidence: 99%

Synthesis and characterization of poly(vinyl alcohol)/chondroitin sulfate composite hydrogels containing strontium‐doped hydroxyapatite as promising biomaterials

Grazioli

Silva

Souza

et al. 2020

J Biomedical Materials Res

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Novel poly(vinyl alcohol)/chondroitin sulfate (PVA/CS) composite hydrogels containing hydroxyapatite (HA) or Sr‐doped HA (HASr) particles were synthesized by a freeze/thaw method and characterized aiming towards biomedical applications. HA and HASr were synthesized by a wet‐precipitation method and added to the composite hydrogels in fractions up to 15 wt%. Physical–chemical characterizations of particles and hydrogels included scanning electron microscopy, energy‐dispersive spectroscopy, Fourier‐transform infrared spectroscopy, X‐ray diffraction, thermogravimetry, porosity, compressive strength/elastic modulus, swelling degree, and cell viability. Particles were irregular in shape and appeared to have narrow size variation. The thermal behavior of composite hydrogels was altered compared to the control (bare) hydrogel. All hydrogels exhibited high porosity. HA/HASr particles reduced total porosity without reducing pore size. The mechanical strength was improved as the fraction of HA or HASr was increased. HASr particles led to a faster water uptake but did not interfere with the total hydrogel swelling capacity. In cell viability essay, increased cell growth (above 120%) was observed in all groups including the control hydrogel, suggesting a bioactive effect. In conclusion, PVA/CS hydrogels containing HA or HASr particles were successfully synthesized and showed promising morphological, mechanical, and swelling properties, which are particularly required for scaffolding.

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Carbon nanotube reinforced polyvinyl alcohol/biphasic calcium phosphate scaffold for bone tissue engineering

Abstract: In this paper, a well-developed porous carbon nanotube (CNT) reinforced polyvinyl alcohol/biphasic calcium phosphate (PVA/BCP) scaffold was fabricated by a freeze-thawing and freeze-drying method.

Cited by 45 publications

References 39 publications

Polyvinyl alcohol/multi‐walledcarbon nanotubes nanocomposites with ordered macroporous structures prepared byice‐templating

Polyvinyl alcohol/multi‐walledcarbon nanotubes nanocomposites with ordered macroporous structures prepared byice‐templating

Fabrication and Characterization of Biodegradable Gelatin Methacrylate/Biphasic Calcium Phosphate Composite Hydrogel for Bone Tissue Engineering

Synthesis and characterization of poly(vinyl alcohol)/chondroitin sulfate composite hydrogels containing strontium‐doped hydroxyapatite as promising biomaterials

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