Carbon Nanotube Polymer Scaffolds as a Conductive Alternative for the Construction of Retinal Sheet Tissue

Yang, Runcai; Yang, Sijing; Li, Kaijing; Luo, Ziming; Xian, Bikun; Tang, Jiaqi; Ye, Meifang; Lu, Shoutao; Zhang, Haijun; Ge, Junbo

doi:10.1021/acschemneuro.1c00242

Cited by 13 publications

(6 citation statements)

References 36 publications

(52 reference statements)

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“…CNT‐based scaffolds and bio‐scaffolds (CNTs combined with polymethyl methacrylate resin matrix) have excellent biocompatibility, electrical conductivity, mechanical strength (up to 1 TPa tensile strength up to 100 GPa, Young's modulus) and biodegradability properties can help in tissue engineering for stem cell proliferation and differentiation applications. [ 75 ] MWCNT‐containing electrospun nanofiber scaffolds in rats showed outstanding peripheral nerve cell regeneration capabilities. [ 76 ] CNT‐based scaffolds can be formulated by combining CNT with natural polymers, synthetic polymers, and calcium phosphate and extensively reported and explored in numerous tissue engineering applications such as tumor (self‐assembling peptide‐CNT), [ 77 ] retinal (CNT/poly d , l ,‐lactic‐ co ‐glycolic acid scaffold), [ 75 ] bone (CNT/carboxymethyl/chitosan hydrogel), [ 78 ] myocardial, neural (CNT/chitosan/polyethylene glycol (PEG)), [ 79 ] cartilage (polycaprolactone/chitosan/CNT) tissue engineering.…”

Section: Cnt Functionalization and Cnt‐hms Synthesismentioning

confidence: 99%

Carbon Nanotube Hybrid Materials: Efficient and Pertinent Platforms for Antifungal Drug Delivery

Chandra,

Reis,

Kundu

et al. 2023

Adv Materials Technologies

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Carbon nanotubes (CNTs) have emerged as the brightest nascent artifact to deliver antifungal drugs in drug delivery applications, health care, and pharmaceutical industries. Excellent physio‐chemical features such as huge surface area, tunable side wall, and microneedle‐like morphology make CNTs suitable for drug carriers. Chemical attachments (covalent and non‐covalent functionalization) result in the formation of functionalized CNTs (F‐CNTs) and CNT‐based hybrid materials (CNT‐HMs). These F‐CNTs and CNT‐HMs have substantial antifungal activity and also have the potential to immobilize antifungal drugs such as amphotericin B, nystatin, curcumin, etc. on the exterior or interior surface, securely transport to the target sites, permeate through bio‐barriers, and release these drugs in a controlled manner. As antifungal drug carriers, F‐CNT and CNT‐HMs exhibit more excellent antifungal activity than other conventional drug delivery systems and have the potency to invade biofilm to circumvent the multidrug resistance of fungal species. This review focuses on CNTs and CNT‐HMs for antifungal drug delivery, including their functionalization methods, drug loading approaches, drug release mechanism, cellular internalization, delivery efficiency, and cellular toxicities with their workaround.

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Section: Cnt Functionalization and Cnt‐hms Synthesismentioning

confidence: 99%

Carbon Nanotube Hybrid Materials: Efficient and Pertinent Platforms for Antifungal Drug Delivery

Chandra,

Reis,

Kundu

et al. 2023

Adv Materials Technologies

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“…A novel study in the field of retinal nerve regeneration using a conductive poly (lactic-co-glycolic acid) (PLGA)/CNTs scaffold. The biodegradability, biocompatibility, and electrical conductivity of scaffold containing CNTs are significantly higher than those of neat PLGA, which resulted in the growth and differentiation of human induced pluripotent stem cells (hiPSCs) into retinal ganglion cells (RGC) ( Yang et al., 2021 ). Hong-Sun et al.…”

Section: Neural Tissue Engineering or Nerve Regenerationmentioning

confidence: 99%

Nanomaterials supported by polymers for tissue engineering applications: A review

Sadraei

Mansoori

Chauhan³

et al. 2022

Heliyon

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“…It also supported BV2 cells and retinal ganglion cells (RGCs). Plus, the scaffold promoted hiPSCs differentiation into retinal ganglion cells [ 173 ].…”

Section: Application Of Carbon-based Scaffold In Tissue Engineeringmentioning

confidence: 99%

Modelling of Stem Cells Microenvironment Using Carbon-Based Scaffold for Tissue Engineering Application—A Review

2021

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A scaffold is a crucial biological substitute designed to aid the treatment of damaged tissue caused by trauma and disease. Various scaffolds are developed with different materials, known as biomaterials, and have shown to be a potential tool to facilitate in vitro cell growth, proliferation, and differentiation. Among the materials studied, carbon materials are potential biomaterials that can be used to develop scaffolds for cell growth. Recently, many researchers have attempted to build a scaffold following the origin of the tissue cell by mimicking the pattern of their extracellular matrix (ECM). In addition, extensive studies were performed on the various parameters that could influence cell behaviour. Previous studies have shown that various factors should be considered in scaffold production, including the porosity, pore size, topography, mechanical properties, wettability, and electroconductivity, which are essential in facilitating cellular response on the scaffold. These interferential factors will help determine the appropriate architecture of the carbon-based scaffold, influencing stem cell (SC) response. Hence, this paper reviews the potential of carbon as a biomaterial for scaffold development. This paper also discusses several crucial factors that can influence the feasibility of the carbon-based scaffold architecture in supporting the efficacy and viability of SCs.

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Carbon Nanotube Polymer Scaffolds as a Conductive Alternative for the Construction of Retinal Sheet Tissue

Cited by 13 publications

References 36 publications

Carbon Nanotube Hybrid Materials: Efficient and Pertinent Platforms for Antifungal Drug Delivery

Carbon Nanotube Hybrid Materials: Efficient and Pertinent Platforms for Antifungal Drug Delivery

Nanomaterials supported by polymers for tissue engineering applications: A review

Modelling of Stem Cells Microenvironment Using Carbon-Based Scaffold for Tissue Engineering Application—A Review

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