Carbon Nanotube Modified Microelectrode Array for Neural Interface

Vafaiee, Mohaddeseh; Mohammadpour, Raheleh; Vossoughi, Manouchehr; Asadian, Elham; Janahmadi, Mahyar; Sasanpour, Pezhman

doi:10.3389/fbioe.2020.582713

Cited by 33 publications

(19 citation statements)

References 78 publications

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“…Brain-machine interfaces such as lab-on-a-chip devices and multielectrode arrays (MEA) also offer great potential for in vitro and in vivo application to study neuronal circuit-connectivity, physiology, and pathology [23]. As recently shown by Vafaiee et al, carbon nanotube modified microelectrode arrays show improved electric properties important for neural interfaces [24]. Currently, 384-multiwell microelectrode arrays are used for the impedimetric monitoring of Tau protein-induced neurodegenerative processes [25].…”

Section: Introductionmentioning

confidence: 99%

Adhesion of Neurons and Glial Cells with Nanocolumnar TiN Films for Brain-Machine Interfaces

Abend

Steele

Jahnke

et al. 2021

IJMS

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Coupling of cells to biomaterials is a prerequisite for most biomedical applications; e.g., neuroelectrodes can only stimulate brain tissue in vivo if the electric signal is transferred to neurons attached to the electrodes’ surface. Besides, cell survival in vitro also depends on the interaction of cells with the underlying substrate materials; in vitro assays such as multielectrode arrays determine cellular behavior by electrical coupling to the adherent cells. In our study, we investigated the interaction of neurons and glial cells with different electrode materials such as TiN and nanocolumnar TiN surfaces in contrast to gold and ITO substrates. Employing single-cell force spectroscopy, we quantified short-term interaction forces between neuron-like cells (SH-SY5Y cells) and glial cells (U-87 MG cells) for the different materials and contact times. Additionally, results were compared to the spreading dynamics of cells for different culture times as a function of the underlying substrate. The adhesion behavior of glial cells was almost independent of the biomaterial and the maximum growth areas were already seen after one day; however, adhesion dynamics of neurons relied on culture material and time. Neurons spread much better on TiN and nanocolumnar TiN and also formed more neurites after three days in culture. Our designed nanocolumnar TiN offers the possibility for building miniaturized microelectrode arrays for impedance spectroscopy without losing detection sensitivity due to a lowered self-impedance of the electrode. Hence, our results show that this biomaterial promotes adhesion and spreading of neurons and glial cells, which are important for many biomedical applications in vitro and in vivo.

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Section: Introductionmentioning

confidence: 99%

Adhesion of Neurons and Glial Cells with Nanocolumnar TiN Films for Brain-Machine Interfaces

Abend

Steele

Jahnke

et al. 2021

IJMS

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“…[112,113] Carbon nanotubes (CNTs) provide a carbon formulation with a high-aspect ratio that is easy to functionalize, and provides stable electrical, mechanical and chemical properties. [106,114] CNT can be spun together to form microelectrode "yarns" in an aligned fashion to form electrical tracks that have a high temporal resolution. [115,116] Tracks containing CNT often demonstrate no change in recording quality over time, and have shown a reduction in activated glial cells and biofouling 6 weeks after implantation.…”

Section: Graphene and Other Carbon Materialsmentioning

confidence: 99%

Materials for Implantable Surface Electrode Arrays: Current Status and Future Directions

Tringides

Mooney

2022

Advanced Materials

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with the outermost layer of biological tissues, often spanning a significant surface area. Devices typically have multiple electrodes that aim to monitor and modulate cells and tissues in a minimally invasive manner, using biomaterials designed to evoke minimal inflammatory responses. Applications of Surface Electrode Arrays RecordingBecause surface electrode arrays can record a "snapshot" of the electrical activity at distinct locations, these arrays are useful to monitor the function of a tissue. Though the recordings are typically local field potentials, with electrodes that are small enough to modulate as little of a location as possible while still maintaining a sufficiently high conductivity, single units from individual cells have been reported. Clinically, these recordings are used to map the epicardial surface to identify instances, and potentially mechanisms, of chronic atrial fibrillation, [1] dysfunction of ventricular tachycardia caused by congenital defects, [2] and other abnormal conduction conditions in the cardiac system. Clinical electrocorticogram (ECoG) is used to identify similar functional changes on the cortical surface of the brain, most commonly to identify epileptic focal center(s), or detect seizure activity. [3][4][5][6][7] Other functional uses of ECoG include intraoperative monitoring during tumor resection. [8] A surgeon can ask a patient to perform an activity such as a speech and then identify and avoid the active cortical regions during surgery, to avoid major disruptions to the patient quality of life. StimulationInstead of passively monitoring electrical activity, multielectrode surface arrays can provide electrical current to the underlying tissue and induce a desired excitatory or inhibitory response. The applications for stimulating surface electrode arrays are often therapeutic and include implantable pacemakers, which restore a normal cardiac rhythm by providing external and overriding cues to the cardiomyocytes responsible for establishing a sinus rhythm. [9] Pulses delivered to specific regions of the spinal cord are used to manage chronic pain, [10][11][12] and more recently as a therapy to promote neuronal plasticity in Surface electrode arrays are mainly fabricated from rigid or elastic materials, and precisely manipulated ductile metal films, which offer limited stretchability. However, the living tissues to which they are applied are nonlinear viscoelastic materials, which can undergo significant mechanical deformation in dynamic biological environments. Further, the same arrays and compositions are often repurposed for vastly different tissues rather than optimizing the materials and mechanical properties of the implant for the target application. By first characterizing the desired biological environment, and then designing a technology for a particular organ, surface electrode arrays may be more conformable, and offer better interfaces to tissues while causing less damage. Here, the various materials used in each component of a surface electrode array are first r...

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“…119,120 Moreover, it also has perfect biocompatibility, flexibility, high mechanical strength, and captivating nerve cell adhesion. 121–123 Based on these ideal characteristics, CNTs have received more and more attraction in the orientation of neural electrodes (Fig. 8a).…”

Section: Current Developing Status Of Neural Electrodesmentioning

confidence: 99%

“…Additionally, Vafaiee and his collaborators prepared a gold multi-electrode array coated with CNTs, and the impedance after CNT modification was reduced by 50%. 121 Not only that, the CNT coated electrode also was able to monitor the electrophysiological activity in vitro . 138…”

Section: Current Developing Status Of Neural Electrodesmentioning

confidence: 99%