Carbon nanotube integration into MEMS devices

Hanein, Yael

doi:10.1002/pssb.201000109

Cited by 13 publications

(9 citation statements)

References 18 publications

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“…Flexible devices were realized by transferring high density MWCNT films onto a flexible PDMS film (Hanein, 2010). A deliberate poor adhesion between the CNT film and the substrate allowed the transfer of the CNTs to the PDMS substrate (Figure 6A).…”

Section: Carbon Nanotubes For Electrical Neuronal Interfacingmentioning

confidence: 99%

Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

Bareket¹,

Hanein²

2013

Front. Neural Circuits

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129

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Carbon nanotube (CNT) coatings have been demonstrated over the past several years as a promising material for neuronal interfacing applications. In particular, in the realm of neuronal implants, CNTs have major advantages owing to their unique mechanical and electrical properties. Here we review recent investigations utilizing CNTs in neuro-interfacing applications. Cell adhesion, neuronal engineering and multi electrode recordings with CNTs are described. We also highlight prospective advances in this field, in particular, progress toward flexible, bio-compatible CNT-based technology.

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Section: Carbon Nanotubes For Electrical Neuronal Interfacingmentioning

confidence: 99%

Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

Bareket¹,

Hanein²

2013

Front. Neural Circuits

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129

120

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“…Nevertheless, the simple fabrication of low-impedance and high-spatial-resolution electrodes still remains an experimental challenge. Attempts to lower the impedance, including the use of advanced interface materials [16][17][18] and patterning of metal electrodes [19][20][21][22], have led to promising results. However, they often require sophisticated techniques of production or lack mechanical stability and longevity.…”

Section: Introductionmentioning

confidence: 99%

Frequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes

et al. 2012

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We present a model to describe the response of chip-based nanocavity sensors during extracellular recording of action potentials. These sensors feature microelectrodes which are embedded in liquid-filled cavities. They can be used for the highly localized detection of electrical signals on a chip. We calculate the sensor's impedance and simulate the propagation of action potentials. Subsequently we apply our findings to analyze cell-chip coupling properties. The results are compared to experimental data obtained from cardiomyocyte-like cells. We show that both the impedance and the modeled action potentials fit the experimental data well. Furthermore, we find evidence for a large seal resistance of cardiomyocytes on nanocavity sensors compared to conventional planar recording systems.

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“…For instance, carbon nanotube electrodes can be integrated into a PDMS layer by the iMP technique. 40 Deformable micro-electrode arrays on a PDMS layer have also been proposed. [41][42][43] By integrating such micro-electrodes into axon guiding tracks with high confinement efficiency, iMP could thus improve the specificity and efficiency of addressing in microelectrode array (MEA) devices.…”

Section: Discussionmentioning

confidence: 99%

In-mold patterning and actionable axo-somatic compartmentalization for on-chip neuron culture

et al. 2016

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Oriented neuronal networks with controlled connectivity are required for many applications ranging from studies of neurodegeneration to neuronal computation. To build such networks in vitro, an efficient, directed and long lasting guidance of axons toward their target is a pre-requisite. The best guidance achieved so far, however, relies on confining axons in enclosed microchannels, making them poorly accessible for further investigation. Here we describe a method providing accessible and highly regular arrays of axons, emanating from somas positioned in distinct compartments. This method combines the use of a novel removable partition, allowing soma positioning outside of the axon guidance patterns, and in-mold patterning (iMP), a hybrid method combining chemical and mechanical cell positioning clues applied here for the first time to neurons. The axon guidance efficiency of iMP is compared to that of conventional patterning methods, e.g. micro-contact printing (chemical constraints by a poly-l-lysine motif) and micro-grooves (physical constraints by homogeneously coated microstructures), using guiding tracks of different widths and spacing. We show that iMP provides a gain of 10 to 100 in axon confinement efficiency on the tracks, yielding mm-long, highly regular, and fully accessible on-chip axon arrays. iMP also allows well-defined axon guidance from small populations of several neurons confined at predefined positions in μm-sized wells. iMP will thus open new routes for the construction of complex and accurately controlled neuronal networks.

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Carbon nanotube integration into MEMS devices

Cited by 13 publications

References 18 publications

Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

Frequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes

In-mold patterning and actionable axo-somatic compartmentalization for on-chip neuron culture

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