Carbon Nanotube-Delivered
            <i>Ic9</i>
            Suicide Gene Therapy for Killing Breast Cancer Cells
            <i>In Vitro</i>

Mohseni-Dargah, Masoud; Akbari‐Birgani, Shiva; Madadi, Zahra; Saghatchi, Fatemeh; Kaboudin, Babak

doi:10.2217/nnm-2018-0342

Cited by 35 publications

(12 citation statements)

References 51 publications

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“…Recent research has shown that this strategy is successful in treating chemo-resistant cancer cell lines [99] and also enhances the effectiveness of radiation during therapy [100]. In this context, Dargah et al demonstrated that iC9 gene induces apoptosis in MCF-7 human breast cancer cell lines [101]. In this study, pyridine modified MWCNTs were used as carriers to transfer the gene of interest.…”

Section: Gene Therapymentioning

confidence: 95%

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Singh

Kumar

2022

Nanomaterials

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Cancer belongs to a category of disorders characterized by uncontrolled cell development with the potential to invade other bodily organs, resulting in an estimated 10 million deaths globally in 2020. With advancements in nanotechnology-based systems, biomedical applications of nanomaterials are attracting increasing interest as prospective vehicles for targeted cancer therapy and enhancing treatment results. In this context, carbon nanotubes (CNTs) have recently garnered a great deal of interest in the field of cancer diagnosis and treatment due to various factors such as biocompatibility, thermodynamic properties, and varied functionalization. In the present review, we will discuss recent advancements regarding CNT contributions to cancer diagnosis and therapy. Various sensing strategies like electrochemical, colorimetric, plasmonic, and immunosensing are discussed in detail. In the next section, therapy techniques like photothermal therapy, photodynamic therapy, drug targeting, gene therapy, and immunotherapy are also explained in-depth. The toxicological aspect of CNTs for biomedical application will also be discussed in order to ensure the safe real-life and clinical use of CNTs.

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Section: Gene Therapymentioning

confidence: 95%

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Singh

Kumar

2022

Nanomaterials

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“…A combination of the introduced pf-MWCNTdelivered iC9 suicide gene therapy and chemotherapy was also performed. Reports showed that pyridine-functionalized multi-walled carbon nanotubes (pf-MWCNT)-delivered iC9 suicide gene therapy and is an effective strategy for killing cancer cells; combination therapy works even better than monotherapy due to overcoming cell cycle arrest resulting from chemical drugs [100]. A novel photoactivatable RNAi system was designed for targeted gene expression in tumor cells.…”

Section: Cnts In Gene Therapymentioning

confidence: 99%

Carbon Nanotubes: Current Perspectives on Diverse Applications in Targeted Drug Delivery and Therapies

et al. 2021

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Current discoveries as well as research findings on various types of carbon nanostructures have inspired research into their utilization in a number of fields. These carbon nanostructures offer uses in pharmacy, medicine and different therapies. One such unique carbon nanostructure includes carbon nanotubes (CNTs), which are one-dimensional allotropes of carbon nanostructure that can have a length-to-diameter ratio greater than 1,000,000. After their discovery, CNTs have drawn extensive research attention due to their excellent material properties. Their physical, chemical and electronic properties are excellent and their composites provide great possibilities for enormous nanometer applications. The current study provides a systematic review based on prior literature review and data gathered from various sources. The various research studies from many research labs and organizations were systematically retrieved, collected, compiled and written. The entire collection and compilation of this review concluded the use of CNT approaches and their efficacy and safety for the treatment of various diseases such as brain tumors or cancer via nanotechnology-based drug delivery, phototherapy, gene therapy, antiviral therapy, antifungal therapy, antibacterial therapy and other biomedical applications. The current review covers diverse applications of CNTs in designing a range of targeted drug delivery systems and application for various therapies. It concludes with a discussion on how CNTs based medicines can expand in the future.

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“…Another gene that has been used is the Escherichia coli cytosine deaminase gene; it encodes for an enzyme that catalyzes conversion of 5-fluorocytosine (5-FC) into 5-fluoruracile (5-FU), a drug used in conventional chemotherapy of HCC, prostate, colon, and breast cancers because it causes cell proliferation inhibition and induces cell death (14,67,71). Furthermore, this approach has been carried out by using a suicide gene which encodes for a modified human Caspase 9 (iCas9), which is strongly recognized by the bioinert synthetic molecule (B/B Homodimer, AP20187), alone or delivered by mesenchymal stromal cells (MSCs), inducing a dimer formation and activation apoptosis pathway in breast and lung cancer cells (72)(73)(74).…”

Section: Suicide Gene Therapymentioning

confidence: 99%

Strategies for Targeting Gene Therapy in Cancer Cells With Tumor-Specific Promoters

et al. 2020

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Cancer is the second cause of death worldwide, surpassed only by cardiovascular diseases, due to the lack of early diagnosis, and high relapse rate after conventional therapies. Chemotherapy inhibits the rapid growth of cancer cells, but it also affects normal cells with fast proliferation rate. Therefore, it is imperative to develop other safe and more effective treatment strategies, such as gene therapy, in order to significantly improve the survival rate and life expectancy of patients with cancer. The aim of gene therapy is to transfect a therapeutic gene into the host cells to express itself and cause a beneficial biological effect. However, the efficacy of the proposed strategies has been insufficient for delivering the full potential of gene therapy in the clinic. The type of delivery vehicle (viral or non viral) chosen depends on the desired specificity of the gene therapy. The first gene therapy trials were performed with therapeutic genes driven by viral promoters such as the CMV promoter, which induces non-specific toxicity in normal cells and tissues, in addition to cancer cells. The use of tumor-specific promoters over-expressed in the tumor, induces specific expression of therapeutic genes in a given tumor, increasing their localized activity. Several cancer- and/or tumor-specific promoters systems have been developed to target cancer cells. This review aims to provide up-to-date information concerning targeting gene therapy with cancer- and/or tumor-specific promoters including cancer suppressor genes, suicide genes, anti-tumor angiogenesis, gene silencing, and gene-editing technology, as well as the type of delivery vehicle employed. Gene therapy can be used to complement traditional therapies to provide more effective treatments.

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Carbon Nanotube-Delivered Ic9 Suicide Gene Therapy for Killing Breast Cancer Cells In Vitro

Cited by 35 publications

References 51 publications

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Cancer Targeting and Diagnosis: Recent Trends with Carbon Nanotubes

Carbon Nanotubes: Current Perspectives on Diverse Applications in Targeted Drug Delivery and Therapies

Strategies for Targeting Gene Therapy in Cancer Cells With Tumor-Specific Promoters

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