Carbon nanotube-composite hydrogels promote intercalated disc assembly in engineered cardiac tissues through β1-integrin mediated FAK and RhoA pathway

Sun, Haiyan; Tang, Jiajia; Mou, Yongchao; Zhou, Jing; Liu, Qu; Duval, Kayla; Huang, Zhu; Lin, Ning; Dai, Ruiwu; Liang, Chengxiao; Chen, Zi; Tang, Lijun; Tian, Fanghua

doi:10.1016/j.actbio.2016.10.025

Cited by 67 publications

(48 citation statements)

References 46 publications

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“…The framework of such materials is a branched CNT network, and the filler is one of the proteins or a protein complex. The effectiveness of the use of CNT for cardiac regeneration is confirmed by the results of many papers [13][14][15][16]. It has been established that the introduction of CNTs into the structure of polymer 124 increases electrical conductivity and improves the excitation threshold of a biomass material [13].…”

Section: Introductionmentioning

confidence: 80%

“…It has been established that the introduction of CNTs into the structure of polymer 124 increases electrical conductivity and improves the excitation threshold of a biomass material [13]. A hydrogel based on methacrylate anhydride and CNT was developed in [14] to support the functioning and growth of cardiomyocytes. It has been shown that the collagen hydrogel reinforced with CNTs significantly improves the functioning of cardiomyocytes [15].…”

Section: Introductionmentioning

confidence: 99%

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Specific Features of Structure, Electrical Conductivity and Interlayer Adhesion of the Natural Polymer Matrix from the Layers of Branched Carbon Nanotube Networks Filled with Albumin, Collagen and Chitosan

et al. 2018

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This paper considers the problem of creating a conductive matrix with a framework made of carbon nanotubes (CNTs) for cell and tissue engineering. In silico investigation of the electrical conductivity of the framework formed by T-junctions of single-walled carbon nanotubes (SWNTs) (12, 12) with a diameter of 1.5 nm has been carried out. A numerical evaluation of the contact resistance and electrical conductivity of seamless and suture T-junctions of SWCNTs is given. The effect of the type of structural defects in the contact area of the tubes on the contact resistance of the T-junction of SWCNTs was revealed. A coarse-grained model of a branched SWCNT network with different structure densities is constructed and its electrical conductivity is calculated. A new layered bioconstruction is proposed, the layers of which are formed by natural polymer matrixes: CNT-collagen, CNT-albumin and CNT-chitosan. The energy stability of the layered natural polymer matrix has been analyzed, and the adhesion of various layers to each other has been calculated. Based on the obtained results, a new approach has been developed in the formation of 3D electrically conductive bioengineering structures for the restoration of cell activity.

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Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Specific Features of Structure, Electrical Conductivity and Interlayer Adhesion of the Natural Polymer Matrix from the Layers of Branched Carbon Nanotube Networks Filled with Albumin, Collagen and Chitosan

et al. 2018

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“…The authors unveiled the pathway that triggers the increased formation of these intercellular structures that are a feature of myocardial tissue. In fact, they showed a pivotal role of β1-integrin-mediated RhoA signaling pathway in the formation of mechanical junction such as adherens junctions and desmosomes were attributed to [79].…”

Section: Effect Of Nanoengineered Materials On Cell Adhesion and Prolmentioning

confidence: 99%

Nanoengineering in Cardiac Regeneration: Looking Back and Going Forward

et al. 2020

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To deliver on the promise of cardiac regeneration, an integration process between an emerging field, nanomedicine, and a more consolidated one, tissue engineering, has begun. Our work aims at summarizing some of the most relevant prevailing cases of nanotechnological approaches applied to tissue engineering with a specific interest in cardiac regenerative medicine, as well as delineating some of the most compelling forthcoming orientations. Specifically, this review starts with a brief statement on the relevant clinical need, and then debates how nanotechnology can be combined with tissue engineering in the scope of mimicking a complex tissue like the myocardium and its natural extracellular matrix (ECM). The interaction of relevant stem, precursor, and differentiated cardiac cells with nanoengineered scaffolds is thoroughly presented. Another correspondingly relevant area of experimental study enclosing both nanotechnology and cardiac regeneration, e.g., nanoparticle applications in cardiac tissue engineering, is also discussed.

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“…Focal adhesion kinase (FAK) was a key intracellular signaling molecules for cell membrane signal transduction, which received signals of extracellular integrins and regulates downstream signaling molecules involved in cell proliferation, differentiation, and migration. [22][23][24] Luo et al 13 proved that the integrin level and p-FAK-to-FAK ratio were positively correlated with HBSMCs proliferation under physiological stretch. Similarly, we found that physiological stretch promoted HUCs proliferation by integrin α6-FAK signaling pathway.…”

Section: Figurementioning

confidence: 99%

Physiological stretch induced proliferation of human urothelial cells via integrin α6‐FAK signaling pathway

Gao

Wei

Liao

et al. 2018

Neurourology and Urodynamics

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Carbon nanotube-composite hydrogels promote intercalated disc assembly in engineered cardiac tissues through β1-integrin mediated FAK and RhoA pathway

Cited by 67 publications

References 46 publications

Specific Features of Structure, Electrical Conductivity and Interlayer Adhesion of the Natural Polymer Matrix from the Layers of Branched Carbon Nanotube Networks Filled with Albumin, Collagen and Chitosan

Specific Features of Structure, Electrical Conductivity and Interlayer Adhesion of the Natural Polymer Matrix from the Layers of Branched Carbon Nanotube Networks Filled with Albumin, Collagen and Chitosan

Nanoengineering in Cardiac Regeneration: Looking Back and Going Forward

Physiological stretch induced proliferation of human urothelial cells via integrin α6‐FAK signaling pathway

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